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1 January 2023

Enabling rethinking

Filed under: books, change, communications, psychology, retrospection — Tags: , — David Wood @ 10:45 pm

At the start of a new year, it’s customary for people to reflect on their life trajectories. Are the visions, attitudes, activities, and alliances, that have brought us to the end of one year, the best set to keep following in the next year?

So, new years are known for retrospectives – reviews of our past successes and disappointments – and for new resolutions – initiatives to change parts of our lifestyles.

My view, however, is that the pace of change in society is so rapid nowadays that we can no longer keep our rethinking – our retrospectives and our new resolutions – to something that just happens occasionally – perhaps once a year.

Moreover, the wide scope of change in society demands a rethinking that is not only more frequent, but also more searching, more radical, and more effective.

Accordingly, perhaps the single most important skill today is the ability to unlearn and relearn, quickly and successfully.

That’s why I put “Learning how to learn” as the very first area (out of 24) in the Vital Syllabus project which I oversee.

It’s also why my attention was drawn to the book Think Again by organizational psychologist Adam Grant.

I was intrigued by the subtitle “The power of knowing what you don’t know”, and by the recommendation on the book cover, “Guaranteed to make you rethink your opinions and your most important decisions”.

I downloaded the audio version of the book to my phone a couple of weeks ago, and started listening to it. I finished it earlier today. It was a great choice to be my last listen of the year.

It’s narrated by the author himself. I see from his biography that he “has been Wharton’s top-rated professor for seven straight years”. After listening to his narration, I’m not at all surprised.

The chapters all involve engaging narratives with several layers of meaning which become clearer as the book progresses. Since I’m widely read myself, the narratives several times touched on material where I had some prior familiarity:

  • Learning from “superforecasters”
  • Learning from the Wright brothers (aviation pioneers)
  • Learning from expert negotiators
  • Learning from debating champions
  • Learning from the tragedies at NASA
  • Learning from the Dunning-Kruger analysis of overconfidence.

But in each case, the author drew attention to extra implications that I had not appreciated before. I’m considerably wiser as a result.

My own specific takeaways from the book are a number of new habits I want to include in my personal reflections and interactions. I see the book as enabling better rethinking:

  • Individually – when I contemplate my own knowledge, skills, and, yes, limitations and doubts
  • Interpersonally – when I bump up against other people with different beliefs, opinions, and loyalties
  • Within communities – so that an organisation is better able to avoid groupthink and more able to successfully pivot when needed
  • Transcending polarisation – by highlighting the complexities of real-world decisions, by encouraging “dancing” rather than conflicts, by expressing a wider range of emotions, and much more.

Because polarisation is such a challenging issue in today’s world, especially in politics (see my comments in this previous book review), the methods Grant highlights are particularly timely.

I’ve already found a couple of videos online that cover some of these points, and added them into various pages of the Vital Syllabus (here and here, so far). I’m sure there’s a lot more material out there, which should likewise be included.

If you have any additional suggestions, don’t hesitate to let me know!

17 December 2022

The best book I read in 2022

Filed under: books — Tags: , , — David Wood @ 12:55 pm

I’ve checked the records I’ve created over the year in Goodreads. I see that, out of the books I read all the way through in 2022, I was inspired to give sixteen the maximum Goodreads rating of five stars out of five.

(Actually mainly I listened to these books, as audio books, rather than read them.)

You can see their covers in the following image.

(Click on the image to enlarge it, to view the individual book covers more clearly.)

Each of these books gave me plenty to think about. I’m grateful in every case for the effort and inspiration of the authors.

But one of these books stands out as being even more impressive and impactful than all the others.

It’s The Revenge of Power, by Moisés Naím.

Here are some extracts from the Wikipedia page of the author:

Moisés Naím (born July 5, 1952, in Tripoli, Libya) is a Venezuelan journalist and writer. He is a Distinguished Fellow at the Carnegie Endowment for International Peace. In 2013, the British magazine Prospect listed Naím as one of the world’s leading thinkers. In 2014 and 2015, Dr. Naím was ranked among the top 100 influential global thought leaders by Gottlieb Duttweiler Institute (GDI).

He is the former Minister of Trade and Industry for Venezuela, Director of its Central bank, and Executive Director of the World Bank.

Naím studied at the Universidad Metropolitana in Caracas, Venezuela. Following his undergraduate studies, he attended the Massachusetts Institute of Technology, where he obtained both a master of science and doctorate degrees.

Naím was a professor of business strategy and industrial economics at Instituto de Estudios Superiores de Administración (IESA), Venezuela’s leading business school and research center located in Caracas. He also served as its Dean between 1979 and 1986.

Naím served as the editor-in-chief of Foreign Policy magazine for 14 years (1996-2010). Since 2012, he has directed and hosted Efecto Naím, a weekly televised news program on the economy and international affairs that airs throughout the Americas on NTN24. In 2011, he received the Ortega y Gasset Prize for his important contribution to journalism in the Spanish language.

Naím ably deploys that rich experience and expertise in the writing of his new book.

The book’s full title is “The Revenge of Power: The Global Assault on Democracy and How to Defeat It”.

Here are the reasons why the book particularly stands out for me, and why I believe you should read it too:

  • The subject has fundamental global importance. All our aspirations in other areas of life – health, education, sport, travel, technology, art – are subject to destruction if politics falls further into the hands of autocrats
  • Every single chapter was eye-opening, introducing important new material
  • The analysis covers threats from both the right and the left, and is full of captivating details about politics in numerous countries around the world
  • The book draws together its various ideas into a coherent overarching framework – the “three P’s” of populism, polarization and post-truth (you might think at first, like I did, that this sounds a bit trite; but be prepared to change your mind)
  • It clarifies what is different, today, compared to the threats posed by autocrats of previous generations
  • It also clarifies how new technological possibilities – compared to the newspapers and radio and TV of the past – pose further challenges to the maintenance of democracy
  • It vividly explains the concept of “status dissonance” that is one of several factors causing electorates to look favourably at potential autocrats
  • It provides a stirring defence of the principles of the separation of powers, and the maintenance of checks and balances.

Many parts of the book are truly frightening. This is not some abstract issue, nor some far-future concern. As the book highlights, it’s a live here-and-now issue. I confess that several episodes it covered left me hopping mad.

Finally, it has specific recommendations on what needs to be done, to ward off the threats posed to the wellbeing of politics around the world. These recommendations are “five battles we need to win” – against falsehoods, criminalized governments, foreign subversion, political cartels and narratives of illiberalism.

None of these battles will be easy. But they’re all winnable, with sufficient effort, intelligence, and collaboration.

8 June 2022

Pre-publication review: The Singularity Principles

Filed under: books, Singularity, Singularity Principles — Tags: — David Wood @ 9:23 am

I’ve recently been concentrating on finalising the content of my forthcoming new book, The Singularity Principles.

The reasons why I see this book as both timely and necessary are explained in the extract, below, taken from the introduction to the book

This link provides pointers to the full text of every chapter in the book. (Or use the links in the listing below of the extended table of contents.)

Please get in touch with me if you would prefer to read the pre-publication text in PDF format, rather than on the online HTML pages linked above.

At this stage, I will gratefully appreciate any feedback:

  • Aspects of the book that I should consider changing
  • Aspects of the book that you particularly like.

Feedback on any parts of the book will be welcome. It’s by no means necessary for you to read the entire text. (However, I hope you will find it sufficiently interesting that you will end up reading more than you originally planned…)

By the way, it’s a relatively short book, compared to some others I’ve written. The wordcount is a bit over 50 thousand words. That works out at around 260 pages of fairly large text on 5″x8″ paper.

I will also appreciate any commendations or endorsements, which I can include with the publicity material for the book, to encourage more people to pay attention to it.

The timescale I have in mind: I will release electronic and physical copies of the book some time early next month (July), followed up soon afterward by an audio version.

Therefore, if you’re thinking of dipping into any chapters to provide feedback and/or endorsements, the sooner the better!

Thanks in anticipation!

Preface

This book is dedicated to what may be the most important concept in human history, namely, the Singularity – what it is, what it is not, the steps by which we may reach it, and, crucially, how to make it more likely that we’ll experience a positive singularity rather than a negative singularity.

For now, here’s a simple definition. The Singularity is the emergence of Artificial General Intelligence (AGI), and the associated transformation of the human condition. Spoiler alert: that transformation will be profound. But if we’re not paying attention, it’s likely to be profoundly bad.

Despite the importance of the concept of the Singularity, the subject receives nothing like the attention it deserves. When it is discussed, it often receives scorn or ridicule. Alas, you’ll hear sniggers and see eyes rolling.

That’s because, as I’ll explain, there’s a kind of shadow around the concept – an unhelpful set of distortions that make it harder for people to fully perceive the real opportunities and the real risks that the Singularity brings.

These distortions grow out of a wider confusion – confusion about the complex interplay of forces that are leading society to the adoption of ever-more powerful technologies, including ever-more powerful AI.

It’s my task in this book to dispel the confusion, to untangle the distortions, to highlight practical steps forward, and to attract much more serious attention to the Singularity. The future of humanity is at stake.

Let’s start with the confusion.

Confusion, turbulence, and peril

The 2020s could be called the Decade of Confusion. Never before has so much information washed over everyone, leaving us, all too often, overwhelmed, intimidated, and distracted. Former certainties have dimmed. Long-established alliances have fragmented. Flurries of excitement have pivoted quickly to chaos and disappointment. These are turbulent times.

However, if we could see through the confusion, distraction, and intimidation, what we should notice is that human flourishing is, potentially, poised to soar to unprecedented levels. Fast-changing technologies are on the point of providing a string of remarkable benefits. We are near the threshold of radical improvements to health, nutrition, security, creativity, collaboration, intelligence, awareness, and enlightenment – with these improvements being available to everyone.

Alas, these same fast-changing technologies also threaten multiple sorts of disaster. These technologies are two-edged swords. Unless we wield them with great skill, they are likely to spin out of control. If we remain overwhelmed, intimidated, and distracted, our prospects are poor. Accordingly, these are perilous times.

These dual future possibilities – technology-enabled sustainable superabundance, versus technology-induced catastrophe – have featured in numerous discussions that I have chaired at London Futurists meetups going all the way back to March 2008.

As these discussions have progressed, year by year, I have gradually formulated and refined what I now call the Singularity Principles. These principles are intended:

  • To steer humanity’s relationships with fast-changing technologies,
  • To manage multiple risks of disaster,
  • To enable the attainment of remarkable benefits,
  • And, thereby, to help humanity approach a profoundly positive singularity.

In short, the Singularity Principles are intended to counter today’s widespread confusion, distraction, and intimidation, by providing clarity, credible grounds for hope, and an urgent call to action.

This time it’s different

I first introduced the Singularity Principles, under that name and with the same general format, in the final chapter, “Singularity”, of my 2021 book Vital Foresight: The Case for Active Transhumanism. That chapter is the culmination of a 642 page book. The preceding sixteen chapters of that book set out at some length the challenges and opportunities that these principles need to address.

Since the publication of Vital Foresight, it has become evident to me that the Singularity Principles require a short, focused book of their own. That’s what you now hold in your hands.

The Singularity Principles is by no means the only new book on the subject of the management of powerful disruptive technologies. The public, thankfully, are waking up to the need to understand these technologies better, and numerous authors are responding to that need. As one example, the phrase “Artificial Intelligence”, forms part of the title of scores of new books.

I have personally learned many things from some of these recent books. However, to speak frankly, I find myself dissatisfied by the prescriptions these authors have advanced. These authors generally fail to appreciate the full extent of the threats and opportunities ahead. And even if they do see the true scale of these issues, the recommendations these authors propose strike me as being inadequate.

Therefore, I cannot keep silent.

Accordingly, I present in this new book the content of the Singularity Principles, brought up to date in the light of recent debates and new insights. The book also covers:

  • Why the Singularity Principles are sorely needed
  • The source and design of these principles
  • The significance of the term “Singularity”
  • Why there is so much unhelpful confusion about “the Singularity”
  • What’s different about the Singularity Principles, compared to recommendations of other analysts
  • The kinds of outcomes expected if these principles are followed
  • The kinds of outcomes expected if these principles are not followed
  • How you – dear reader – can, and should, become involved, finding your place in a growing coalition
  • How these principles are likely to evolve further
  • How these principles can be put into practice, all around the world – with the help of people like you.

The scope of the Principles

To start with, the Singularity Principles can and should be applied to the anticipation and management of the NBIC technologies that are at the heart of the current, fourth industrial revolution. NBIC – nanotech, biotech, infotech, and cognotech – is a quartet of four interlinked technological disruptions which are likely to grow significantly stronger as the 2020s unfold. Each of these four technological disruptions has the potential to fundamentally transform large parts of the human experience.

However, the same set of principles can and should also be applied to the anticipation and management of the core technology that will likely give rise to a fifth industrial revolution, namely the technology of AGI (artificial general intelligence), and the rapid additional improvements in artificial superintelligence that will likely follow fast on the footsteps of AGI.

The emergence of AGI is known as the technological singularity – or, more briefly, as the Singularity.

In other words, the Singularity Principles apply both:

  • To the longer-term lead-up to the Singularity, from today’s fast-improving NBIC technologies,
  • And to the shorter-term lead-up to the Singularity, as AI gains more general capabilities.

In both cases, anticipation and management of possible outcomes will be of vital importance.

By the way – in case it’s not already clear – please don’t expect a clever novel piece of technology, or some brilliant technical design, to somehow solve, by itself, the challenges posed by NBIC technologies and AGI. These challenges extend far beyond what could be wrestled into submission by some dazzling mathematical wizardry, by the incorporation of an ingenious new piece of silicon at the heart of every computer, or by any other “quick fix”. Indeed, the considerable effort being invested by some organisations in a search for that kind of fix is, arguably, a distraction from a sober assessment of the bigger picture.

Better technology, better product design, better mathematics, and better hardware can all be part of the full solution. But that full solution also needs, critically, to include aspects of organisational design, economic incentives, legal frameworks, and political oversight. That’s the argument I develop in the chapters ahead.

Extended table of contents

For your convenience, here’s a listing of the main section headings for all the chapters in this book.

0. Preface

  • Confusion, turbulence, and peril
  • This time it’s different
  • The scope of the Principles
  • Collective insight
  • The short form of the Principles
  • The four areas covered by the Principles
  • What lies ahead

1. Background: Ten essential observations

  • Tech breakthroughs are unpredictable (both timing and impact)
  • Potential complex interactions make prediction even harder
  • Changes in human attributes complicate tech changes
  • Greater tech power enables more devastating results
  • Different perspectives assess “good” vs. “bad” differently
  • Competition can be hazardous as well as beneficial
  • Some tech failures would be too drastic to allow recovery
  • A history of good results is no guarantee of future success
  • It’s insufficient to rely on good intentions
  • Wishful thinking predisposes blindness to problems

2. Fast-changing technologies: risks and benefits

  • Technology risk factors
  • Prioritising benefits?
  • What about ethics?
  • The transhumanist stance

2.1 Special complications with artificial intelligence

  • Problems with training data
  • The black box nature of AI
  • Interactions between multiple algorithms
  • Self-improving AI
  • Devious AI
  • Four catastrophic error modes
  • The broader perspective

2.2 The AI Control Problem

  • The gorilla problem
  • Examples of dangers with uncontrollable AI
  • Proposed solutions (which don’t work)
  • The impossibility of full verification
  • Emotion misses the point
  • No off switch
  • The ineffectiveness of tripwires
  • Escaping from confinement
  • The ineffectiveness of restrictions
  • No automatic super ethics
  • Issues with hard-wiring ethical principles

2.3 The AI Alignment Problem

  • Asimov’s Three Laws
  • Ethical dilemmas and trade-offs
  • Problems with proxies
  • The gaming of proxies
  • Simple examples of profound problems
  • Humans disagree
  • No automatic super ethics (again)
  • Other options for answers?

2.4 No easy solutions

  • No guarantees from the free market
  • No guarantees from cosmic destiny
  • Planet B?
  • Humans merging with AI?
  • Approaching the Singularity

3. What is the Singularity?

  • Breaking down the definition
  • Four alternative definitions
  • Four possible routes to the Singularity
  • The Singularity and AI self-awareness
  • Singularity timescales
  • Positive and negative singularities
  • Tripwires and canary signals
  • Moving forward

3.1 The Singularitarian Stance

  • AGI is possible
  • AGI could happen within just a few decades
  • Winner takes all
  • The difficulty of controlling AGI
  • Superintelligence and superethics
  • Not the Terminator
  • Opposition to the Singularitarian Stance

3.2 A complication: the Singularity Shadow

  • Singularity timescale determinism
  • Singularity outcome determinism
  • Singularity hyping
  • Singularity risk complacency
  • Singularity term overloading
  • Singularity anti-regulation fundamentalism
  • Singularity preoccupation
  • Looking forward

3.3 Bad reasons to deny the Singularity

  • The denial of death
  • How special is the human mind?
  • A credible positive vision

4. The question of urgency

  • Factors causing AI to improve
  • 15 options on the table
  • The difficulty of measuring progress
  • Learning from Christopher Columbus
  • The possibility of fast take-off

5. The Singularity Principles in depth

5.1 Analysing goals and potential outcomes

  • Question desirability
  • Clarify externalities
  • Require peer reviews
  • Involve multiple perspectives
  • Analyse the whole system
  • Anticipate fat tails

5.2 Desirable characteristics of tech solutions

  • Reject opacity
  • Promote resilience
  • Promote verifiability
  • Promote auditability
  • Clarify risks to users
  • Clarify trade-offs

5.3 Ensuring development takes place responsibly

  • Insist on accountability
  • Penalise disinformation
  • Design for cooperation
  • Analyse via simulations
  • Maintain human oversight

5.4 Evolution and enforcement

  • Build consensus regarding principles
  • Provide incentives to address omissions
  • Halt development if principles are not upheld
  • Consolidate progress via legal frameworks

6. Key success factors

  • Public understanding
  • Persistent urgency
  • Reliable action against noncompliance
  • Public funding
  • International support
  • A sense of inclusion and collaboration

7. Questions arising

7.1 Measuring human flourishing

  • Some example trade-offs
  • Updating the Universal Declaration of Human Rights
  • Constructing an Index of Human and Social Flourishing

7.2 Trustable monitoring

  • Moore’s Law of Mad Scientists
  • Four projects to reduce the dangers of WMDs
  • Detecting mavericks
  • Examples of trustable monitoring
  • Watching the watchers

7.3 Uplifting politics

  • Uplifting regulators
  • The central role of politics
  • Toward superdemocracy
  • Technology improving politics
  • Transcending party politics
  • The prospects for political progress

7.4 Uplifting education

  • Top level areas of the Vital Syllabus
  • Improving the Vital Syllabus

7.5 To AGI or not AGI?

  • Global action against the creation of AGI?
  • Possible alternatives to AGI?
  • A dividing line between AI and AGI?
  • A practical proposal

7.6 Measuring progress toward AGI

  • Aggregating expert opinions
  • Metaculus predictions
  • Alternative canary signals for AGI
  • AI index reports

7.7. Growing a coalition of the willing

  • Risks and actions

Image credit

The draft book cover shown above includes a design by Pixabay member Ebenezer42.

26 May 2021

A preview of Vital Foresight

Filed under: books, Vital Foresight — Tags: , , — David Wood @ 8:33 am

Update on 23rd June 2021: Vital Foresight has now been published as an ebook and as a paperback.

Here are the Amazon links:

The open preview mentioned in this post has now ended.

For more details about the book, including endorsements by early readers, see here.

The original blogpost follows:


Vital Foresight is almost ready.

That’s the title of the book I’ve been writing since August. It’s the most important book I’ve ever written.

The subtitle is The Case for Active Transhumanism.

Below, please find a copy of the Preface to Vital Foresight. The preface summarises the scope and intent of the book, and describes its target audience.

At this time, I am inviting people to take a look at previews of one or more of the chapters, and, if you feel inspired, to offer some feedback.

Here are examples of what I encourage you to make comments or suggestions about:

  • You particularly like some of the material
  • You dislike some of the material
  • You think contrary opinions should be considered
  • There appear to be mistakes in the spelling or grammar
  • The material is difficult to read or understand
  • The ideas could be expressed more elegantly
  • You have any other thoughts you wish to share.

Unless you indicate a preference for anonymity, reviewers will be thanked in the Acknowledgements section at the end of the book.

The chapters can be accessed as Google Doc files. Here’s the link to the starting point.

This article lists twenty key features of the book – topics it covers in unique ways.

And, for your convenience, here’s a copy of the Preface.

Preface

“Transhumanism”?

“Don’t put that word on the cover of your book!”

That’s the advice I received from a number of friends when they heard what I was writing about. They urged me to avoid “the ‘T’ word” – “transhumanism”. That word has bad vibes, they said. It’s toxic. T for toxic.

I understand where they’re coming from. Later in this book, I’ll dig into reasons why various people are uncomfortable with the whole concept. I’ll explain why I nevertheless see “transhumanism” as an apt term for a set of transformational ideas that will be key to our collective wellbeing in the 2020s and beyond. T for transformational. And, yes, T for timely.

As such, it’s a word that belongs on the cover of many more books, inspiring more conversations, more realisations, and more breakthroughs.

For now, in case you’re wondering, here’s a short definition. It’s by Oxford polymath Anders Sandberg, who expressed it like this in 1997:

Transhumanism is the philosophy that we can and should develop to higher levels, physically, mentally, and socially, using rational methods.

Sandberg’s 1997 webpage also features this summary from trailblazing Humanity+ Board member and Executive Director, Natasha Vita-More:

Transhumanism is a commitment to overcoming human limits in all their forms, including extending lifespan, augmenting intelligence, perpetually increasing knowledge, achieving complete control over our personalities and identities, and gaining the ability to leave the planet. Transhumanists seek to achieve these goals through reason, science, and technology.

In brief, transhumanism is a vision of the future: a vision of what’s possible, what’s desirable, and how it can be brought into reality.

In subsequent chapters, I’ll have lots more to say about the strengths and weaknesses of transhumanism. I’ll review the perceived threats and the remarkable opportunities that arise from it. But first, let me quickly introduce myself and how I came to be involved in the broader field of foresight (also known as futurism) within which transhumanism exists.

Smartphones and beyond

Over the twenty-five years that I held different roles within the mobile computing and smartphone industries, it was an increasingly central part of my job to think creatively and critically about future possibilities.

Back in the late 1980s and early 1990s, my work colleagues and I could see that computing technology was becoming ever more powerful. We debated long and hard, revisiting the same questions many times as forthcoming new hardware and software capabilities came to our attention. What kinds of devices should we design, to take advantage of these new capabilities? Which applications would users of these devices find most valuable? How might people feel as they interacted with different devices with small screens and compact keypads? Would the Internet ever become useful for “ordinary people”? Would our industry be dominated by powerful, self-interested corporations with monolithic visions, or would multiple streams of innovation flourish?

My initial involvement with these discussions was informal. Most of my time at work went into software engineering. But I enjoyed animated lunchtime discussions at Addison’s brasserie on Old Marylebone Road in central London, where technical arguments about, for example, optimising robust access to data structures, were intermingled with broader brainstorms about how we could collectively steer the future in a positive direction.

Over time, I set down more of my own ideas in writing, in emails and documents that circulated among teammates. I also had the good fortune to become involved in discussions with forward-thinking employees from giants of the mobile phone world – companies such as Nokia, Ericsson, Motorola, Panasonic, Sony, Samsung, Fujitsu, and LG, that were considering using our EPOC software (later renamed as “Symbian OS”) in their new handsets. I learned a great deal from these discussions.

By 2004 my job title was Executive VP for Research. It was my responsibility to pay attention to potential disruptions that could transform our business, either by destroying it, or by uplifting it. I came to appreciate that, in the words of renowned management consultant Peter Drucker, “the major questions regarding technology are not technical but human questions”. I also became increasingly persuaded that the disruptions of the smartphone market, significant though they were, were but a small preview of much larger disruptions to come.

As I’ll explain in the pages ahead, these larger disruptions could bring about a significant uplift in human character. Another possibility, however, is the destruction of much that we regard as precious.

Accordingly, the skills of foresight are more essential today than ever. We need to strengthen our collective capabilities in thinking creatively and critically about future possibilities – and in acting on the insights arising.

Indeed, accelerating technological change threatens to shatter the human condition in multiple ways. We – all of us – face profound questions over the management, not just of smartphones, but of artificial intelligence, nanoscale computers, bio-engineering, cognitive enhancements, ubiquitous robots, drone swarms, nuclear power, planet-scale geo-engineering, and much more.

What these technologies enable is, potentially, a world of extraordinary creativity, unprecedented freedom, and abundant wellbeing. That’s provided we can see clearly enough, in advance, the major disruptive opportunities we will need to seize and steer, so we can reach that destination. And provided we can step nimbly through a swath of treacherous landmines along the way.

That’s no small undertaking. It will take all our wisdom and strength. It’s going to require the very highest calibre of foresight.

That’s the reason why I’ve spent so much of my time in recent years organising and hosting hundreds of public meetings of the London Futurists community, both offline and online – events with the general headline of “serious analysis of radical scenarios for the next three to forty years”.

I acknowledge, however, that foresight is widely thought to have a poor track record. Forecasts of the future, whether foretelling doom and gloom, or envisioning technological cornucopia, seem to have been wrong at least as often as they have been right. Worse, instead of helping us to see future options more clearly, past predictions have, all too frequently, imposed mental blinkers, encouraged a stubborn fatalism, or distracted us from the truly vital risks and opportunities. It’s no wonder that the public reputation of futurism is scarcely better than that of shallow tabloid horoscopes.

To add to the challenge, our long-honed instincts about social norms and human boundaries prepare us poorly for the counterintuitive set of radical choices that emerging technology now dangles before us. We’re caught in a debilitating “future shock” of both fearful panic and awestruck wonder.

Happily, assistance is at hand. What this book will demonstrate is that vital foresight from the field I call active transhumanism can help us all:

  1. To resist unwarranted tech hype, whilst remaining aware that credible projections of today’s science and engineering could enable sweeping improvements in the human condition
  2. To distinguish future scenarios with only superficial attractions from those with lasting, sustainable benefits
  3. To move beyond the inaction of future shock, so we can coalesce around practical initiatives that advance deeply positive outcomes.

The audience for vital foresight

I’ve written this book for everyone who cares about the future:

  • Everyone trying to anticipate and influence the dramatic changes that may take place in their communities, organisations, and businesses over the next few years
  • Everyone concerned about risks of environmental disaster, the prevalence of irrationalism and conspiracy theories, growing inequality and social alienation, bioengineered pandemics, the decline of democracy, and the escalation of a Cold War 2.0
  • Everyone who has high hopes for technological solutions, but who is unsure whether key innovations can be adopted wisely enough and quickly enough
  • Everyone seeking a basic set of ethical principles suited for the increasing turbulence of the 2020s and beyond – principles that preserve the best from previous ethical frameworks, but which are open to significant updates in the wake of the god-like powers being bestowed on us by new technologies.

Although it reviews some pivotal examples from my decades of experience in business, this is not a book about the future of individual businesses or individual industries.

Nor is it a “get rich quick” book, or one that promotes “positive thinking” or better self-esteem. Look elsewhere, if that is what you seek.

Instead, it’s a book about the possibilities – indeed, the necessity – for radical transformation:

  • Transformation of human nature
  • Transformation of our social and political frameworks
  • Transformation of our relations with the environment and the larger cosmos
  • Transformation of our self-understanding – the narratives we use to guide all our activities.

Critically, this book contains practical suggestions for next steps to be taken, bearing in mind the power and pace of forces that are already remaking the world faster than was previously thought possible.

And it shows that foresight, framed well, can provide not only a stirring vision, but also the agility and resilience to cope with the many contingencies and dangers to be encountered on the journey forward.

Looking ahead

Here’s my summary of the most vital piece of foresight that I can offer.

Oncoming waves of technological change are poised to deliver either global destruction or a paradise-like sustainable superabundance, with the outcome depending on the timely elevation of transhumanist vision, transhumanist politics, and transhumanist education.

You’ll find that same 33-word paragraph roughly halfway through the book, in the chapter “Creativity”, in the midst of a dialogue about (can you guess…?) hedgehogs and foxes. I’ve copied the paragraph to the beginning of the book to help you see where my analysis will lead.

The summary is short, but the analysis will take some time. The scenarios that lie ahead for humanity – whether global destruction or sustainable superabundance – involve rich interactions of multiple streams of thought and activity. There’s a lot we’ll need to get our heads around, including disruptions in technology, health, culture, economics, politics, education, and philosophy. Cutting corners on understanding any one of these streams could yield a seriously misleading picture of our options for the future. Indeed, if we skimp on our analysis of future possibilities, we should not be surprised if humanity falls far short of our true potential.

However, I realise that each reader of this book will bring different concerns and different prior knowledge. By all means jump over various sections of the book to reach the parts that directly address the questions that are uppermost in your mind. Let the table of contents be your guide. If need be, you can turn back the pages later, to fill in any gaps in the narrative.

Better foresight springs, in part, from better hindsight. It’s particularly important to understand the differences between good foresight and bad foresight – to review past examples of each, learning from both the failures and, yes, the occasional successes of previous attempts to foresee and create the future. That’s one of our key tasks in the pages ahead.

In that quest, let’s move forward to an example from the rainbow nation of South Africa. Before we reach the hedgehogs and foxes, I invite you to spend some time with (can you guess…?) ostriches and flamingos.

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1 March 2021

The imminence of artificial consciousness

Filed under: AGI, books, brain simulation, London Futurists — Tags: , , — David Wood @ 10:26 am

I’ve changed my mind about consciousness.

I used to think that, of the two great problems about artificial minds – namely, achieving artificial general intelligence, and achieving artificial consciousness – progress toward the former would be faster than progress toward the latter.

After all, progress in understanding consciousness had seemed particularly slow, whereas enormous numbers of researchers in both academia and industry have been attaining breakthrough after breakthrough with new algorithms in artificial reasoning.

Over the decades, I’d read a number of books by Daniel Dennett and other philosophers who claimed to have shown that consciousness was basically already understood. There’s nothing spectacularly magical or esoteric about consciousness, Dennett maintained. What’s more, we must beware being misled by our own introspective understanding of our consciousness. That inner introspection is subject to distortions – perceptual illusions, akin to the visual illusions that often mislead us about what we think our eyes are seeing.

But I’d found myself at best semi-convinced by such accounts. I felt that, despite the clever analyses in such accounts, there was surely more to the story.

The most famous expression of the idea that consciousness still defied a proper understanding is the formulation by David Chalmers. This is from his watershed 1995 essay “Facing Up to the Problem of Consciousness”:

The really hard problem of consciousness is the problem of experience. When we think and perceive, there is a whir of information-processing, but there is also a subjective aspect… There is something it is like to be a conscious organism. This subjective aspect is experience.

When we see, for example, we experience visual sensations: the felt quality of redness, the experience of dark and light, the quality of depth in a visual field. Other experiences go along with perception in different modalities: the sound of a clarinet, the smell of mothballs. Then there are bodily sensations, from pains to orgasms; mental images that are conjured up internally; the felt quality of emotion, and the experience of a stream of conscious thought. What unites all of these states is that there is something it is like to be in them. All of them are states of experience.

It is undeniable that some organisms are subjects of experience. But the question of how it is that these systems are subjects of experience is perplexing. Why is it that when our cognitive systems engage in visual and auditory information-processing, we have visual or auditory experience: the quality of deep blue, the sensation of middle C? How can we explain why there is something it is like to entertain a mental image, or to experience an emotion?

It is widely agreed that experience arises from a physical basis, but we have no good explanation of why and how it so arises. Why should physical processing give rise to a rich inner life at all? It seems objectively unreasonable that it should, and yet it does.

However, as Wikipedia notes,

The existence of a “hard problem” is controversial. It has been accepted by philosophers of mind such as Joseph Levine, Colin McGinn, and Ned Block and cognitive neuroscientists such as Francisco Varela, Giulio Tononi, and Christof Koch. However, its existence is disputed by philosophers of mind such as Daniel Dennett, Massimo Pigliucci, Thomas Metzinger, Patricia Churchland, and Keith Frankish, and cognitive neuroscientists such as Stanislas Dehaene, Bernard Baars, Anil Seth and Antonio Damasio.

With so many smart people apparently unable to agree, what hope is there for a layperson to have any confidence in an answering the question, is consciousness already explained in principle, or do we need some fundamentally new insights?

It’s tempting to say, therefore, that the question should be left to one side. Instead of squandering energy spinning circles of ideas with little prospect of real progress, it would be better to concentrate on numerous practical questions: vaccines for pandemics, climate change, taking the sting out of psychological malware, protecting democracy against latent totalitarianism, and so on.

That practical orientation is the one that I have tried to follow most of the time. But there are four reasons, nevertheless, to keep returning to the question of understanding consciousness. A better understanding of consciousness might:

  1. Help provide therapists and counsellors with new methods to address the growing crisis of mental ill-health
  2. Change our attitudes towards the suffering we inflict, as a society, upon farm animals, fish, and other creatures
  3. Provide confidence on whether copying of memories and other patterns of brain activity, into some kind of silicon storage, could result at some future date in the resurrection of our consciousness – or whether any such reanimation would, instead, be “only a copy” of us
  4. Guide the ways in which systems of artificial intelligence are being created.

On that last point, consider the question whether AI systems will somehow automatically become conscious, as they gain in computational ability. Most AI researchers have been sceptical on that score. Google Maps is not conscious, despite all the profoundly clever things that it can do. Neither is your smartphone. As for the Internet as a whole, opinions are a bit more mixed, but again, the general consensus is that all the electronic processing happening on the Internet is devoid of the kind of subjective inner experience described by David Chalmers.

Yes, lots of software has elements of being self-aware. Such software contains models of itself. But it’s generally thought (and I agree, for what it’s worth) that such internal modelling is far short of subjective inner experience.

One prospect this raises is the dark possibility that humans might be superseded by AIs that are considerably more intelligent than us, but that such AIs would have “no-one at home”, that is, no inner consciousness. In that case, a universe with AIs instead of humans might have much more information processing, but be devoid of conscious feelings. Mega oops.

The discussion at this point is sometimes led astray by the popular notion that any threat from superintelligent AIs to human existence is predicated on these AIs “waking up” or become conscious. In that popular narrative, any such waking up might give an AI an additional incentive to preserve itself. Such an AI might adopt destructive human “alpha male” combative attitudes. But as I say, that’s a faulty line of reasoning. AIs might well be motivated to preserve themselves without ever gaining any consciousness. (Look up the concept of “basic AI drives” by Steve Omohundro.) Indeed, a cruise missile that locks onto a target poses a threat to that target, not because the missile is somehow conscious, but because it has enough intelligence to navigate to its target and explode on arrival.

Indeed, AIs can pose threats to people’s employment, without these AIs gaining consciousness. They can simulate emotions without having real internal emotions. They can create artistic masterpieces, using techniques such as GANs (Generative Adversarial Networks), without having any real psychological appreciation of the beauty of these works of art.

For these reasons, I’ve generally urged people to set aside the question of machine consciousness, and to focus instead on the question of machine intelligence. (For example, I presented that argument in Chapter 9 of my book Sustainable Superabundance.) The latter is tangible and poses increasing threats (and opportunities), whereas the former is a discussion that never seems to get off the ground.

But, as I mentioned at the start, I’ve changed my mind. I now think it’s possible we could have machines with synthetic consciousness well before we have machines with general intelligence.

What’s changed my mind is the book by Professor Mark Solms, The Hidden Spring: A Journey to the Source of Consciousness.

Solms is director of neuropsychology in the Neuroscience Institute of the University of Cape Town, honorary lecturer in neurosurgery at the Royal London Hospital School of Medicine, and an honorary fellow of the American College of Psychiatrists. He has spent his entire career investigating the mysteries of consciousness. He achieved renown within his profession for identifying the brain mechanisms of dreaming and for bringing psychoanalytic insights into modern neuroscience. And now his book The Hidden Spring is bringing him renown far beyond his profession. Here’s a selection of the praise it has received:

  • A remarkably bold fusion of ideas from psychoanalysis, psychology, and the frontiers of theoretical neuroscience, that takes aim at the biggest question there is. Solms will challenge your most basic beliefs.
    Matthew Cobb, author of The Idea of the Brain: The Past and Future of Neuroscience
  • At last the emperor has found some clothes! For decades, consciousness has been perceived as an epiphenomenon, little more than an illusion that can’t really make things happen. Solms takes a thrilling new approach to the problem, grounded in modern neurobiology but finding meaning in older ideas going back to Freud. This is an exciting book.
    Nick Lane, author of The Vital Question
  • To say this work is encyclopaedic is to diminish its poetic, psychological and theoretical achievement. This is required reading.
    Susie Orbach, author of In Therapy
  • Intriguing…There is plenty to provoke and fascinate along the way.
    Anil Seth, Times Higher Education
  • Solms’s efforts… have been truly pioneering. This unification is clearly the direction for the future.
    Eric Kandel, Nobel laureate for Physiology and Medicine
  • This treatment of consciousness and artificial sentience should be taken very seriously.
    Karl Friston, scientific director, Wellcome Trust Centre for Neuroimaging
  • Solms’s vital work has never ignored the lived, felt experience of human beings. His ideas look a lot like the future to me.
    Siri Hustvedt, author of The Blazing World
  • Nobody bewitched by these mysteries [of consciousness] can afford to ignore the solution proposed by Mark Solms… Fascinating, wide-ranging and heartfelt.
    Oliver Burkeman, Guardian
  • This is truly a remarkable book. It changes everything.
    Brian Eno

At times, I had to concentrate hard while listening to this book, rewinding the playback multiple times. That’s because the ideas kept sparking new lines of thought in my mind, which ran off in different directions as the narration continued. And although Solms explains his ideas in an engaging manner, I wanted to think through the deeper connections with the various fields that form part of the discussion – including psychoanalysis (Freud features heavily), thermodynamics (Helmholtz, Gibbs, and Friston), evolution, animal instincts, dreams, Bayesian statistics, perceptual illusions, and the philosophy of science.

Alongside the theoretical sections, the book contains plenty of case studies – from Solms’ own patients, and from other clinicians over the decades (actually centuries) – that illuminate the points being made. These studies involve people – or animals – with damage to parts of their brains. The unusual ways in which these subjects behave – and the unusual ways in which they express themselves – provide insight on how consciousness operates. Particularly remarkable are the children born with hydranencephaly – that is, without a cerebral cortex – but who nevertheless appear to experience feelings.

Having spent two weeks making my way through the first three quarters of the book, I took the time yesterday (Sunday) to listen to the final quarter, where there were several climaxes following on top of each other – addressing at length the “Hard Problem” ideas of David Chalmers, and the possibility of artificial consciousness.

It’s challenging to summarise such a rich set of ideas in just a few paragraphs, but here are some components:

  • To understand consciousness, the subcortical brain stem (an ancient part of our anatomy) is at least as important as the cognitive architecture of the cortex
  • To understand consciousness, we need to pay attention to feelings as much as to memories and thought processing
  • Likewise, the chemistry of long-range neuromodulators is at least as important as the chemistry of short-range neurotransmitters
  • Consciousness arises from particular kinds of homeostatic systems which are separated from their environment by a partially permeable boundary: a structure known as a “Markov blanket”
  • These systems need to take actions to preserve their own existence, including creating an internal model of their external environment, monitoring differences between incoming sensory signals and what their model predicted these signals would be, and making adjustments so as to prevent these differences from escalating
  • Whereas a great deal of internal processing and decision-making can happen automatically, without conscious thought, some challenges transcend previous programming, and demand greater attention

In short, consciousness arises from particular forms of information processing. (Solms provides good reasons to reject the idea that there is a basic consiciousness latent in all information, or, indeed, in all matter.) Whilst more work requires to be done to pin down the exact circumstances in which consciousness arises, this project is looking much more promising now, than it did just a few years ago.

This is no idle metaphysics. The ideas can in principle be tested by creating artificial systems that involve particular kinds of Markov blankets, uncertain environments that pose existential threats to the system, diverse categorical needs (akin to the multiple different needs of biologically conscious organisms), and layered feedback loops. Solms sets out a three-stage process whereby such systems could be built and evolved, in a relatively short number of years.

But wait. All kinds of questions arise. Perhaps the most pressing one is this: If such systems can be built, should we build them?

That “should we” question gets a lot of attention in the closing sections of the book. We might end up with AIs that are conscious slaves, in ways that we don’t have to worry about for our existing AIs. We might create AIs that feel pain beyond that which any previous conscious being has ever experienced it. Equally, we might create AIs that behave very differently from those without consciousness – AIs that are more unpredictable, more adaptable, more resourceful, more creative – and more dangerous.

Solms is doubtful about any global moratorium on such experiments. Now that the ideas are out of the bag, so to speak, there will be many people – in both academia and industry – who are motivated to do additional research in this field.

What next? That’s a question that I’ll be exploring this Saturday, 6th March, when Mark Solms will be speaking to London Futurists. The title of his presentation will be “Towards an artificial consciousness”.

For more details of what I expect will be a fascinating conversation – and to register to take part in the live question and answer portion of the event – follow the links here.

29 December 2020

The best book on the science of aging in the last ten years

Filed under: aging, books, rejuveneering, science, The Abolition of Aging — Tags: , — David Wood @ 10:44 am

Science points to many possibilities for aging to be reversed. Within a few decades, medical therapies based on these possibilities could become widespread and affordable, allowing all of us, if we wish, to remain in a youthful state for much longer than is currently the norm – perhaps even indefinitely. Instead of healthcare systems continuing to consume huge financial resources in order to treat people with the extended chronic diseases that become increasingly common as patients’ bodies age, much smaller expenditure would keep all of us much healthier for the vast majority of the time.

Nevertheless, far too many people fail to take these possibilities seriously. They believe that aging is basically inevitable, and that people who say otherwise are deluded and/or irresponsible.

Public opinion matters. Investments made by governments and by businesses alike are heavily influenced by perceived public reaction. Without active public support for smart investments in support of the science and medicine that could systematically reverse aging, that outcome will be pushed backwards in time – perhaps even indefinitely.

What can change this public opinion? An important part of the answer is to take the time to explain the science of aging in an accessible, engaging way – including the many recent experimental breakthroughs that, collectively, show such promise.

That’s exactly what Dr Andrew Steele accomplishes in his excellent book Ageless: The new science of getting older without getting old.

The audio version of this book became available on Christmas Eve, narrated by Andrew himself. It has been a delight to listen to it over the intervening days.

Over the last few years, I’ve learned a great deal from a number of books that address the science of aging, and I’ve been happy to recommend these books to wider audiences. These include:

But I hope that these esteemed authors won’t mind if I nominate Andrew Steele’s book as a better starting point into the whole subject. Here’s what’s special about it:

  • It provides a systematic treatment of the science, showing clear relationships between the many different angles to what is undeniably a complex subject
  • The way it explains the science seems just right for the general reader with a good basic education – neither over-simplified or over-dense
  • There’s good material all the way through the book, to keep readers turning the pages
  • The author is clearly passionate about his research, seeing it as important, but he avoids any in-your-face evangelism
  • The book avoids excessive claims or hyperbole: the claims it makes are, in my view, always well based
  • Where research results have been disappointing, there’s no attempt to hide these or gloss over them
  • The book includes many interesting anecdotes, but the point of these stories is always the science, rather than the personalities or psychologies of the researchers involved, or clashing business interests, or whatever
  • The information it contains is right up to date, as of late 2020.

Compared to other research, Ageless provides a slightly different decomposition of what is known as the hallmarks of aging, offering ten in total:

  1. DNA damage and mutations
  2. Trimmed telomeres
  3. Protein problems: autophagy, amyloids and adducts
  4. Epigenetic alterations
  5. Accumulation of senescent cells
  6. Malfunctioning mitochondria
  7. Signal failure
  8. Changes in the microbiome
  9. Cellular exhaustion
  10. Malfunction of the immune system

As the book points out, there are three criteria for something to be a useful “hallmark of aging”:

  1. It needs to increase with age
  2. Accelerating a hallmark’s progress should accelerate aging
  3. Reducing the hallmark should decrease aging

The core of the book is a fascinating survey of interventions that could reduce each of these hallmarks and thereby decrease aging – that is, decrease the probability of dying in the next year. These interventions are grouped into four categories:

  1. Remove
  2. Replace
  3. Repair
  4. Reprogram

Each category of intervention is in turn split into several subgroups. Yes, the treatment of aging is likely to be complicated. However, there are plenty of examples in which single interventions turned out to have multiple positive effects on different hallmarks of aging.

There are a couple of points where some readers might quibble with the content, for example regarding dietary supplements, or whether the concept of group selection can ever be useful within evolutionary theory.

However, my own presentations on the subject of the abolition of aging will almost certainly evolve in the light of the framework and examples in Ageless. I’m much the wiser from reading it.

Here’s my advice to anyone who, like me, believes the subject of reversing aging is important, and who wishes to accelerate progress in this field:

  • Read Ageless with some care, all the way through
  • Digest its contents and explore the implications, for example via discussion in online groups
  • Recommend others to read it too.

Ideally, a sizeable proportion of the book’s readers will alter their own research or other activity, in order to assist the projects covered in Ageless.

Finally, a brief comparison between Ageless and the remarkable grandfather book of this whole field: Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime, authored by Aubrey de Grey and Michael Rae. Ending Aging was published in 2007 and remains highly relevant, even though numerous experimental findings and new ideas have emerged since its publication. There’s a deep overlap in the basic approach advocated in the two books. Both books are written by polymaths who are evidently very bright – people who, incidentally, did their first research in fields outside biology, and who brought valuable external perspectives to the field.

So I see Ageless as a worthy successor to Ending Aging. Indeed, it’s probably a better starting point for people less familiar with this field, in view of its coverage of important developments since 2007, and some readers may find Andrew’s writing style more accessible.

31 July 2020

The future of AI: 12 possible breakthroughs, and beyond

Filed under: AGI, books, disruption — Tags: , , , , — David Wood @ 1:30 pm

The AI of 5-10 years time could be very different from today’s AI. The most successful AI systems of that time will not simply be extensions of today’s deep neural networks. Instead, they are likely to include significant conceptual breakthroughs or other game-changing innovations.

That was the argument I made in a presentation on Thursday to the Global Data Sciences and Artificial Intelligence meetup. The chair of that meetup, Pramod Kunji, kindly recorded the presentation.

You can see my opening remarks in this video:

A copy of my slides can be accessed on Slideshare.

The ideas in this presentation raise many important questions, for which there are, as yet, only incomplete answers.

Indeed, the future of AI is a massive topic, touching nearly every area of human life. The greater the possibility that AI will experience cascading improvements in capability, the greater the urgency of exploring these scenarios in advance. In other words, the greater the need to set aside hype and predetermined ideas, in order to assess matters objectively and with an independent mind.

For that reason, I’ve joined with Rohit Talwar of Fast Future and Ben Goertzel of SingularityNET in a project to commission and edit chapters in a forthcoming book, “The Future of AI: Pathways to Artificial General Intelligence”.

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We’re asking AI researchers, practitioners, analysts, commentators, policy makers, investors, futurists, economists, and writers from around the world, to submit chapters of up to 1,000 words, by the deadline of 15th September, that address one or more of the following themes:

  • Capability, Applications, and Impacts
    • How might the capabilities of AI systems evolve in the years ahead?
    • What can we anticipate about the potential evolution from today’s AI to AGI and beyond, in which software systems will match or exceed human cognitive abilities in every domain of thought?
    • What possible scenarios for the emergence of significantly more powerful AI deserve the most attention?
    • What new economic concepts, business models, and intellectual property ownership frameworks might be enabled and required as a result of advances that help us transition from today’s AI to AGI?
  • Pathways to AGI
    • What incremental steps might help drive practical commercial and humanitarian AI applications in the direction of AGI?
    • What practical ideas and experiences can be derived from real-world applications of technologies like transfer learning, unsupervised and reinforcement learning, and lifelong learning?
    • What are the opportunities and potential for “narrow AGI” applications that bring increasing levels of AGI to bear within specific vertical markets and application areas?
  • Societal Readiness
    • How can we raise society-wide awareness and understanding of the underlying technologies and their capabilities?
    • How can governments, businesses, educators, civil society organizations, and individuals prepare for the range of possible impacts and implications?
    • What other actions might be taken by individuals, by local groups, by individual countries, by non-governmental organizations (NGOs), by businesses, and by international institutions, to help ensure positive outcomes with advanced AI? How might we reach agreement on what constitutes a positive societal outcome in the context of AI and AGI?
  • Governance
    • How might societal ethical frameworks need to evolve to cope with the new challenges and opportunities that AGI is likely to bring?
    • What preparations can be made, at the present time, for the introduction and updating of legal and political systems to govern the development and deployment of AGI?

For more details of this new book, the process by which chapters will be selected, and processing fees that may apply, click here.

I’m very much looking forward to the insights that will arise – and to the critical new questions that will no doubt arise along the way.

 

14 May 2020

The second coming of the Longevity Dividend

Please find below an extended copy of my remarks at today’s online Round Table of the Business Coalition for Healthier Longer Lives, jointed hosted by the UK’s APPG (All Party Parliamentary Group) on Longevity and Longevity Leaders.

(The stated goal of today’s Round Table is “Development of values for the Business Coalition for Healthier Longer Lives”.)

I’m David Wood, and I’ve been researching future scenarios for over 30 years.

The concept I want to put on the table today is that of the Longevity Dividend.

It’s actually a kind of second coming of the Longevity Dividend, since the idea was first proposed some 14 years ago by a quartet of distinguished longevity researchers (PDF).

It’s a good concept, but didn’t take hold in its first coming, for reasons I’ll get to shortly.

The core idea is that it is economically sensible – that is, financially wise – for society to make investments in research,

  • not just into individual aspects of aging,
  • nor just into individual diseases of aging,
  • but rather into the common root causes of many of the diseases and other adverse characteristics of aging

– that is, research into items we would nowadays call the hallmarks of aging.

The argument is that such investments wouldn’t just be positive from a humanitarian point of view. They would also be very positive from a medium-term financial point of view.

We can sum up their likely benefits in the age-old saying, a stitch in time saves nine. Healthier long-lived people are better contributors to the economy, and better consumers of the economy, rather than being a nine-fold drain.

To move forwards with this concept of the Longevity Dividend, we have to acknowledge that the calculations of costs and benefits are inherently probabilistic.

There are no guarantees that any particular research investments will prove successful. But that’s no reason for society to avoid making these investments into the hallmarks of aging. VCs already know well how to adjust their portfolios on account of probabilistic calculations.

The reason the first coming of the Longevity Dividend didn’t get very far, in the public mind, was that people implicitly rated the probabilities of these therapies succeeding as being very low. Why speculate about potential economic benefits of biorejuvenation interventions if these interventions have little chance of working? However, with lots of more promising research having taken place in the last 14 years, it’s no longer possible to wave away this calculation of significant benefits. So it’s time to bring the Longevity Dividend into the centre stage of public discussion.

The Longevity Dividend has a partner concept: that of Super Agers. They’re people who reach the age of 95 with minimal experience of cancer, heart disease, dementia, or diabetes. Of course, these Super Agers do succumb to one or other disease in due course. Often an infection. But the total healthcare cost of these people, throughout their long lives, is usually less than the total healthcare cost of people who have shorter lives. Quite a lot less total healthcare cost.

So one way to realise the Longevity Dividend would be to put more research into understanding what’s different about Super Agers.

But why isn’t this happening (or not happening much)? We need to go deeper into this topic.

We need to reflect on the general poor regard that society places in practice into any measures that prevent diseases rather than curing them.

Previous discussions in this series of Round Tables have highlighted how our societal incentive structures are deeply flawed in this regard.

Without addressing this misalignment, there’s unlikely to be much progress with the Longevity Dividend.

So one of the big outcomes of our collective deliberations must be to demand sustained attention to the question of how to alter society’s overall priorities and incentives.

And there’s an important lesson from history here, which will be my final remarks for now. That lesson is that the free market, by itself, cannot fix problems of flawed societal incentives. That kind of thing needs political action. But the politicians can be aided in this by industry groups stepping forward with specific agreed proposals.

It’s similar to how factory owners actually helped pressurise politicians in this country, two centuries ago, into changing the law about children working in their factories.

These factory owners saw that economic incentives were pressurising them into employing children, against their own humanitarian instincts. Many of these factory owners, as individuals, felt unable to stop hiring children, for fear of being out-competed and going out of business. It needed a change in law to cause that practice to change. And networks of factory inspectors to ensure conformance to the law.

Working out a similar change of law in the early 2020s is surely a key practical activity for this business coalition, so that prevention moves to centre stage, and with it, the concepts of Longevity Dividend and Super Agers. Thank you.

Further reading

For an extended analysis of the economic arguments about the Longevity Dividend, see Chapter 9, “Money Matters”, of my book The Abolition of Aging.

For the reasons why people disregard the economic and other logical arguments in favour of society investing more in a potential forthcoming radical extension of healthy human longevity, see Chapter 10, “Adverse Psychology”, of the same book.

For the example of the coalition to change the laws on child employment, see the section “When competition needs to be curtailed” in Chapter 9, “Markets and fundamentalists” of my book Transcending Politics.

 

5 December 2019

Nano comes to life

Filed under: books, healthcare, nanotechnology, Oxford — Tags: , , , — David Wood @ 12:44 am

To make progress in biotechnology, the discipline of software engineering will be key. Right?

After all, life is the outcome of what is known as the genetic code. Our biological metabolism is the execution of that code in our cells, extra cellular structures, organs, various circulatory systems, and so on. Admittedly, that code lacks documentation, and has no comments to guide our understanding. Indeed, it has been described as worse than the worst of human-written “spaghetti” code. Such is the complexity. But in due course, we can expect the painstaking application of methods of reverse software engineering to induce biology to give up its deepest secrets. Right?

Not so fast. The message in the recent new book by Oxford University Professor Sonia Contera, Nano Comes to Life, is that if we want to make better progress with biology, we need to increase our understanding of physics. Yes, physics – including mechanics, surface tension, electrostatic forces, dynamic motion, and so on.

Consider our DNA. Parts of our chromosomes consist of genes that cause our cells to create various proteins. The mapping of elements of chromosomes to specific proteins is, indeed, governed by a genetic code. The elucidation of that code has been one of the great triumphs of scientific endeavour in the last hundred years. That same endeavour, however, threw up a puzzle: large parts of our DNA – perhaps the majority of it – seem to be “junk”. It consists of multiple copies of genes that no longer create proteins. Various ideas developed for why these DNA segments exist – viewing them as self-serving, or “selfish”: they exist because they are copied into new generations, and that’s all there is to say about the matter.

However, there’s more than one level to think about our DNA. Yes, it consists of genes. But it also exists as a complex 3D structure, which folds and coils. Depending on the precise folding and coiling – and on whether some molecular groups known as methyls or acetyls are added into a kind of skin for the DNA – different genes are exposed to chemical interactions. We say that different genes can be turned “on” or “off”. Without the long chains of intermediary so-called “junk” DNA between various genes, these 3D interactions wouldn’t take place. The folding and coiling would be different. In other words, junk DNA may be purposeful after all, not in terms of its biochemical interactions, but in terms of its mechanical interactions.

One suggestion in Nano Comes to Life is that mechanical pressure on a cell can result in pressure on the nucleus of the cell, which can, in turn, change the precise 3D shapes of various chromosomes, altering which genes are turned on or off. In other words, external stresses and strains from the environment could directly alter the genetic expressions inside cells.

The limits of reductionism

The suggestion just given is but one example of a thesis which Nano Comes to Life brilliantly highlights: we should avoid becoming carried away with the methodology of reductionism. Reductionism looks for the causes of complex phenomena in a fuller analysis of the constituent parts of the larger system. To understand human biology we need to understand cells. To understand cells we need to understand chemistry. To understand chemistry we need to understand physics. To understand physics we need to understand mathematics. All that is true… but it is not the whole story.

I confess that when I hear people criticising reductionism, I become apprehensive. I half expect the conversation to continue as follows: we cannot understand biology in terms of chemistry, so that proves that aliens did it. Or that psychic telepathy exists. Or that humans are designed by a supernatural deity. Or that magic dwells deep in the universe. Or some other (unjustified) leap of faith.

However, emphatically, that’s not the kind of criticism of reductionism that you’ll find in Nano Comes to Life. Instead, the message is a kind of restatement of the saying often attributed to Einstein:

Everything should be made as simple as possible, but not simpler.

In other words, true progress in biology is likely to come, not from single-minded pursuits of individual lines of thinking, but, instead, from the interplay of multiple levels of understanding. That interplay can give rise to emergence.

Progress in multiple fields

Nano Comes to Life contains an impressive survey of fast progress that is being made in multiple labs around the world (in research universities and in commercial settings) precisely by adopting this multi-level thinking. The book brings readers up to date with remarkable recent research breakthroughs in techniques such as:

  • DNA nanotechnology (including DNA origami),
  • novel protein synthesis via nanotechnology,
  • nanomaterials and transmaterials – which combine features of biological materials with those from outside biology,
  • the creation of replacement organs, as well as “organs on a chip” (very useful for drug testing purposes),
  • targeted cancer drug delivery systems,
  • avoidance of the threat of growing antibiotic resistance,
  • enhancing the immune system,
  • and other aspects of what is known as nanomedicine.

The book also provides fascinating insight into the history and practice of cutting-edge laboratory science.

The context: a vision delayed

I’ve been aware of the field of nanotechnology since some time around the year 1990, when I came across the very first book written on that subject. That book was Engines of Creation: The Coming Era of Nanotechnology, by Eric Drexler (first published in 1986). Reading that book that significantly raised my awareness of the scale of the profound positive transformation that technology could in due course enable in the human condition. Reflecting the importance of that book on the subsequent trajectory of my thinking, a picture of me holding my copy of it was my cover photo on Facebook for a number of years.

(Thanks to Yanna Buryak for snapping this picture of me at just the right moment.)

Eric Drexler’s 1986 book foresaw the eventual deliberate systematic manipulation of matter to create myriad nanoscale levers, shafts, conveyor belts, gears, pulleys, motors, and more. In ways broadly similar to the marvellous operation of ribosomes within biological cells, specially designed nanofactories will be able to utilise atomically precise engineering to construct numerous kinds of new material products, molecule by molecule.  But whereas the natural nanotechnology of ribosomes involves processes that evolved by blind evolution, synthetic nanotechnology will involve processes intelligently designed by human scientists. These scientists will take inspiration from biological templates, but can look forward to reaching results far transcending those of nature.

But despite the upbeat vision of Engines of Creation, progress with many of the ideas Drexler envisioned has proven disappointingly slow. Although the word “nanotechnology” has entered general parlance, it has mainly referred to developments that fall considerably short of the full vision of nanofactories. Thus we have nanomaterials, including nanowires and nanoshells. We have techniques of 3D printing that operate at the nanoscale. We have nanoparticles with increasing numbers of uses. However, the full potential of nanotechnology, envisioned all these years ago by Drexler, remains a future vision.

What Sonia Contera’s book Nano Comes To Life provides, however, is a comprehensive summary of progress within the last few years – and grounds for foreseeing continuing progress ahead.

Why the 2010s are the new 1830s

A clear sign of progress – at last – with nanomachines was the award of the Nobel Prize for Chemistry in 2016. This prize was jointly received by Fraser Stoddart from Scotland, Bernard Feringa from the Netherlands, and Jean-Pierre Sauvage from France, in recognition of their pioneering work in this field – such as finding ways to convert chemical energy into purposeful mechanical motion.

As the Nobel committee remarked, nanomachines in the 2010s are at a roughly similar situation to electrical motors of the 1830s: the basic principles of the manufacture and operation of these machines are just becoming clear. The scientists in the 1830s who demonstrated a variety spinning cranks and wheels, powered by electricity, could hardly have foreseen the subsequent wide incorporation of improved motors in consumer goods such as food processors, air conditioning fans, and washing machines. Likewise, as nanomachines gain more utility, they can be expected to revolutionise manufacturing, healthcare, and the treatment of waste.

It is these future revolutions which feature in Nano Comes to Life – particularly in the field of medicine and health. Importantly, these future revolutions are described in the book, not as any kind of inevitable development, but as something whose form and value will depend critically on choices taken by humans – individually and collectively. Indeed, in an epilogue to the book, the author points to a number of encouraging trends in how scientists, technologists, general citizens, and artists, are interacting to raise the probability that the full benefits of nanotechnology will be spread widely and fairly throughout society. It’s another example of the need to think about matters at more than one level at the same time.

The messages in that final section are ones with which I wholeheartedly agree.

Postscript: For a deeper dive

To hear Sonia Contera present her ideas in more depth, and to join a public Q&A discussion about the implications, check out the London Futurists event happening this Saturday (7th December).

13 November 2019

The astonishing backstory to fracking, Russia, and the dangers of capitalism out of control

Blowout is truly a standout. It brilliantly illuminates powerful forces behind ongoing changes in the oil and gas industry. As the book makes clear, we underestimate these forces at our peril. Accordingly, Blowout deserves a wide readership.

Rachel Maddow, the author of Blowout, doubles as the narrator of the book’s audio version. She also hosts a nightly public affairs show on MSNBC. She reads her own words with great panache. It’s as if the listener could see the knowing winks. Indeed, whilst listening to Blowout, I was prompted to laugh on loud on occasion – before feeling pangs of guilt for having taken pleasure at various all-too-human episodes of duplicity, hubris, and downfall. This isn’t really a laughing matter, though the humour helps our sanity. The future may depend on how well we take to heart the lessons covered in Blowout.

Despite the sharp critical commentary, the book also offers a lot of sympathy. Although the oil and gas industry is portrayed – as in the subtitle of the book – as “the most destructive industry on earth” – and as a strong cause of “corrupted democracy” and “rogue states” – the narrative also shows key actors of this industry in, for a while, a positive light. These individuals see themselves as heroic defenders of important ideals, including energy independence and entrepreneurial verve. Blowout shows that there’s considerable merit in this positive self-assessment. However, very importantly, it’s by no means the whole story.

Blowout interweaves a number of absorbing, captivating tales about larger-than-life individuals, decades-long technological innovation, some of the world’s most successful companies, and clashes of realpolitik. The structure is similar to a pattern often found in novels. At first it’s not clear how the different narrative strands will relate to each other. The connections become clear in stages – vividly clear.

Together, these accounts provide the backstory for various items that frequently appear in the news:

  • The transformation of the oil and gas industry by the technology of fracking (fracturing)
  • Oil executives being seemingly unconcerned about interacting with repulsive autocratic politicians
  • Russian political leaders taking steps to destabilise democracy in the US and in the EU
  • The long relationship between Vladimir Putin and former US Secretary of State Rex Tillerson
  • The activities of people whose names have featured in the Mueller investigation – including Paul Manafort and Dmytro Firtash
  • The floods of aggressive denial against the findings of scientists that activities of the oil and gas industry risk humongous environmental damage.

Blowout deserves a five-star rating for several different reasons. The discussion of the history of fracking, by itself, should be of great interest to anyone concerned about the general principles of technological disruption. The development of fracking conforms to the common pattern of a disruption lingering through a long, slow, disappointing phase, before accelerating to have a bigger impact than even the cheerleaders of the technology previously expected. It also produces a strong example of how an industry cannot be trusted to self-regulate. The industry will have too strong a motivation to downplay the “unexpected side effects” of the new technology. It’s chilling how oil and gas industry experts sought to silence any suggestion that fracking could be the cause of increased earthquakes. It’s also chilling how people who should have know better rushed to adopt various daft pseudo-scientific explanations for this increase.

The book’s account of oil-induced corruption in Equatorial Guinea is also highly relevant (not to mention gut-wrenching). The bigger picture, as Blowout ably explains, is addressed by the concept of “the paradox of plenty”. Of even greater interest is the application of this same theory to developments within Russia.

Alongside tales of epic human foolishness (including the disaster of the Deepwater Horizon oil spill, and the bizarre experience of Shell’s experimental drilling in the Artic), the book offers some genuine inspiration. One example is the growing democratic push-back in the state of Oklahoma, against the previous dominance in that state of the oil and gas industry. Another example is the way in which by no means every country with a “plenty” of oil falls victim to the “paradox” of poorer overall social wellbeing.

In the end, Blowout emphasises, criticising the behaviour of the oil and gas industry makes as little sense as criticising a lion for having the temerity to hunt and eat prey. The solution cannot be merely to appeal to the good conscience of the executives in that industry. Instead, it’s up to governments to set the frameworks within which that industry operates.

In turn, it makes strong internal sense for executives in that industry to seek to undermine any such regulatory framework. We should not be surprised at the inventiveness of that industry and its supporters in finding fault with regulations, in obscuring the extent to which that industry benefits from long-standing subsidies and kickbacks, and in undermining effective international democratic collaboration (such as in the EU). Instead, we need clear-minded political leadership who can outflank the industry, so that we gain its remarkable benefits but avoid its equally remarkable downsides. And what will help political leaders to gain a clearer mind is if the analysis in Blowout becomes better known. Much better known.

PS Some of the same analysis is also covered in this recent video in the series about the Technoprogressive Roadmap:

 

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