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30 September 2016

A declaration for radical healthspan extension

Filed under: aging, healthcare, medicine, rejuveneering, Uncategorized — Tags: , , , — David Wood @ 5:26 pm

I’m writing during a short break in the proceedings of the 2016 Eurosymposium on Healthy Ageing, which is being held in central Brussels.

The organisers have in mind that attendees could issue a declaration at the end of the event, tomorrow, Saturday 1st October – a date which happens to be Longevity Day.

Please find some draft text for this declaration. Lots of other text has been proposed too, but this is a fairly minimal version.

Before the text of the declaration is finalised, I’m interested to hear comments:

  • What should be added – or omitted?
  • What’s unclear?
  • What do people particularly like about it?
  • What improvements might be made to the language?
  • What changes (if any) would convince you to add your signature to it?
  • What’s a good way to conclude the declaration?

Please let us know!

Note: Many thanks are due to various members and supporters of Heales for suggesting text – especially Didier Coeurnelle.

(Update 6pm Brussels time 1st October – the draft text has evolved. The latest version is below.)

declaration-v3

The Brussels Declaration for Radical Healthspan Extension

The defeat of aging lies within our collective grasp. It’s time to seize this remarkable opportunity.

This 1st of October 2016, during International Longevity Day, the Eurosymposium on Healthy Ageing (EHA) meeting in Brussels proclaims the possibility and the imperative of a moonshot project to overcome all age-related diseases within 25 years by tackling aging as their root cause.

The result will be a world:

  • Where healthcare is far less expensive
  • Where human well-being can be radically extended
  • Where people place greater value on the environment and on peace, in view of their expectation of much longer lives
  • Where the right to life is more precious than ever, because life is longer.

Key steps in this initiative will include:

  • A paradigm shift stressing the need for research on aging itself, rather than only on individual diseases of old age
  • The removal of regulatory and other barriers which prevent or disincentivize companies from developing treatments for aging itself
  • An accelerated program to test anti-aging interventions on a much larger scale than anything that exists at the moment, leading to multiple human clinical trials of genuine rejuvenation biotechnologies by 2021.

These programs will require a coordinated effort at national and international level, integrating diverse existing and novel research approaches. They need to be financed by both public and private organizations, and create inclusive, affordable solutions available on equal terms to everybody.

23 June 2016

Acceptance and change

Is it narcissist to seek a cure for aging? Is it egocentric or immature?

That’s an accusation that often comes my way.

The short answer is that it’s no more narcissist to seek a cure for aging than it is to seek a cure for cancer, or for dementia. (Moreover, as I argue in Chapter 2 of my book The Abolition of Aging, the most effective route to cure cancer may well be to cure aging first.)

Nor was it narcissist of previous medical pioneers to seek cures for TB, or for malaria.

Nor was it narcissist for slaves to dare to want to be free of their bondage. Nor was it narcissist for women to dare to want the right to vote. Thank goodness.

Suffragettes 1024x576

There’s a section in Chapter 1 of The Abolition of Aging where I review a variant of this argument. Here’s a copy of that section.

Acceptance and change

At first glance, rejuveneers seem to stand opposed to a profound piece of humanitarian wisdom – wisdom expressed by, among others, Gautama Buddha, 2nd century Stoic advocate Marcus Aurelius, and 20th century American Protestant theologian Reinhold Niebuhr.

That wisdom urges serenity and acceptance in the face of life’s deep challenges. There’s no merit in becoming unnecessarily agitated about an issue – such as the onset of aging – if there’s nothing that can be done about that issue. Why discuss a painful problem if you can’t change the outcome? What’s the point of complaining if there’s no solution available?

It’s as stated in the opening lines of Niebuhr’s famous “serenity prayer” (a prayer that everyone can appreciate, without any need to believe in a supernatural deity):

God grant me
The serenity to accept the things I cannot change…

A similar thought lies at the heart of Buddhism. The “Four Noble Truths” state that suffering arises from attachment to desires, and that suffering ceases only when attachment to desire ceases. To transcend the omnipresence of suffering, we have to learn to accept life as it is, and to set aside desire – such as the desire for better material possessions, pleasure, security, or long life.

The Stoic philosophy of life, developed in ancient Greece and Rome, likewise emphasises an attitude of acceptance. As Epictetus (55-135 AD) stated,

Freedom is secured not by the fulfilling of men’s desires, but by the removal of desire.

Stoic advocate Marcus Aurelius (121-180 AD), who was emperor of Rome for the last 19 years of his life, posed the following questions in his “Meditations”:

Why do you hunger for length of days? The point of life is to follow reason and the divine spirit and to accept whatever nature sends you. To live in this way is not to fear death, but to hold it in contempt. Death is only a thing of terror for those unable to live in the present. Pass on your way, then, with a smiling face, under the smile of him who bids you go.

Admiration of “Stoic calm” persists to the present day. Former American president Bill Clinton has been quoted as saying that “Meditations of Marcus Aurelius” was his favourite book. Stoicism is highlighted by self-education advocate Paul Jun as providing “9 Principles to Help You Keep Calm in Chaos”:

Not only does philosophy teach us how to live well and become better humans, but it can also aid in overcoming life’s trials and tribulations. Some schools of thought are for more abstract thinking and debate, whereas others are tools that are immediately practical to our current endeavours.

The principles within Stoicism are, perhaps, the most relevant and practical sets of rules for entrepreneurs, writers, and artists of all kinds. The Stoics focus on two things:

  1. How can we lead a fulfilling, happy life?
  2. How can we become better human beings?

The goal of Stoicism is to attain inner peace by overcoming adversity, practicing self-control, being conscious of our impulses, realizing our ephemeral nature and the short time allotted—these were all meditative practices that helped them live with their nature and not against it.

It is in contrast to these philosophies of mature acceptance – philosophies that emphasise uncomplaining acknowledgement of our finitude and our limits – that rejuveneers can be portrayed as arrogant, grasping, and juvenile. Rejuveneers dare to complain about the perceived insult of deteriorative aging. Rejuveneers have the audacity to imagine that an outcome unavailable to the greats of the past – including giants such as Marcus Aurelius, Reinhold Niebuhr, and Gautama Buddha – namely, the option of indefinite youthfulness – might shortly be available to present-day folk. Rejuveneers, according to this line of thought, lack the self-awareness to realise how unreasonable their ambition is. Indeed, the hubris of the rejuveneers can seem absurd.

Three sages

But the quotes given above tell only a part of the story. For example, there’s more to Buddhism than acceptance. Buddhist mindfulness coach Sunada Takagi comments as follows:

Acceptance is the first step toward change

I recently had a couple people raise doubts to me about the Buddhist idea of “accepting what is.” Isn’t it too passive? What if we’re in a situation that’s really unacceptable?

I’ve come across a few things recently that speak to this. Each makes a slightly different point, but they all basically say the same thing. “Accepting what is” does not mean passive acquiescence. Far from it, it’s the first step in making real and lasting change…

So “accepting what is” is not about passivity at all. It’s about clear seeing… Paradoxically, it’s when we take responsibility for our own failings and difficulties, or those of the world around us, that the real process of change can begin to take place. I see it as an essential starting point for anything we take on in life.

Paul Jun, the writer I quoted above on the Stoic philosophy, also adopts a strong action-orientation. For him, being stoical is far from being passive. It can, as he says, be the prelude to urgency:

Remind yourself that time is our most precious resource

What I particularly love and find challenging about Stoicism is that death is at the forefront of their thoughts. They realized the ephemeral nature of humans and how this is repeated in many facets of life.

It provides a sense of urgency, to realize that you’ve lived a certain number of hours and the hours ahead of you are not guaranteed as the ones you have lived. When I think of this I realize that everyday truly is an opportunity to improve, not in a cliché kind of way, but to learn to honestly appreciate what we are capable of achieving and how we are very responsible for the quality of our lives.

This makes our self-respect, work ethic, generosity, self-awareness, attention, and growth ever more important. The last thing any of us wants to do is die with regret, hence why following principles of Stoicism puts your life into perspective. It humbles you and should also deeply motivate you.

That brings us back to the serenity prayer of Reinhold Niebuhr. Above, I quoted the first clause of that prayer – the so-called “acceptance clause”. But there are two more clauses: an action clause and a wisdom clause. Here’s the entirety:

God grant me
The serenity to accept the things I cannot change
The courage to change the things that I can
And the wisdom to know the difference
.

Just as people can, rightly, be criticised for foolhardily attempting to change something that cannot be altered, so also can they, again rightly, be criticised for passively accepting some massive flaw or shortcoming which, it turns out, lay within their capacity to fix.

The most important clause in this prayer, arguably, is the “wisdom clause”: if we can find out, objectively, whether something lies within our collective ability, it makes all the difference as to whether the right thing to do is to seek accommodation or to seek transformation.

For rejuveneering, I have no doubt that the right thing to do is to seek transformation. Doing otherwise would be akin – to borrow another motif from Christian heritage – to walking past on the other side of the road, keeping well away from an unfortunate traveller who has been mugged, stripped of his clothing, and left half dead. When regarding the unfortunate state of everyone around the world that is already “half dead” due to the approach of diseases of old age, who amongst us will prove to be a “good Samaritan” that sees the plight and provides tangible support? And who, in contrast, will be like the priest and the Levite of the biblical parable, rushing past with eyes averted, preoccupied with whatever else fits the accepting-aging paradigm?

Footnote

I’ll be addressing some of the themes of The Abolition of Aging at a London Futurists event this Saturday. Click here for more details.

DW Scenarios for life extension Slide 18

10 June 2016

Lessons from Underground Airlines

In the grand sweep of history, how much difference can one person make?

For example, consider the influence of Abraham Lincoln, 16th President of the United States. What alternative history might have arisen if that great statesman had been felled by an assassin’s bullet, not (as in actual history) in 1865, after the conclusion of the American Civil War, but much earlier in his presidency?

That alternative scenario provides the backdrop to the speculative novel “Underground Airlines” by Ben H. Winter. It’s a novel that speculates, masterfully, about the trajectory of an alternative history.

Underground Airlines

Imagine if early martyrdom of Lincoln, before any civil war could start, had precipitated a colossal long-standing compromise in the United States, with northern anti-slavery states warily coexisting with southern pro-slavery states, not just for a few more years, but for long decades – indeed, right up until the present day. Imagine if the “underground railroad” rescue mechanism of safe houses and secret routes to transport fugitive escaped slaves, that existed in actual history from the 17th to the 19th century, persisted in modified, modernised form right up until the twenty first century, now known as “underground airlines” (the words which form the title of Winter’s book). Imagine if the latest features of modern society – such as GPS tracking and ubiquitous mobile computers – coexisted with industrial scale slavery in the “Hard Four” recalcitrant states of the deep south. And, worst of all, imagine an extension, right up till today, of the massive double think (self-deception) in which good people persuade themselves that the whole system is acceptable. Imagine the double think with which these bystanders view fugitive slaves on the run, as fair game to be hunted by trackers from the south acting on behalf of massive slave-holding conglomerates.

Winter’s book features double think writ large. Characters that, to outward appearances, seek to help runaway slaves, are secretly assisting the trackers, and allow themselves to feel comfortable with that double think. They accept the brute facts of slavery, and make peace (of a sort) with their personal accommodation to that worldview.

Personalities from actual history intrude, under the skilful choreography of the writer, into the alternative Underground Airlines history. Shunned by much of the rest of the industrialised world, the alternative America occupies a relative backwater on the global stage. The FDR and LBJ mentioned in quiet moments in the narrative wielded an impact far more local, in Underground Airlines history, than in actual history. A reference to a recent “gulf war” turns out to have nothing to do with the Middle East.

More than clever plotting

Winter’s book deserves praise for its clever plotting. Revelations of character motivations come as surprises, but not as jolts: the reader is gradually made aware of a bigger picture with its own, horrible logic. It adds up to gripping reading.

But more than that: Underground Airlines deserves praise for its astuteness in recognising that there was nothing inevitable about the abolition of slavery. The circumstances that we nowadays find overwhelmingly objectionable – the “Inhuman Bondage” described at length by real-world historian David Brion Davis in his epic account of the rise and fall of new world slavery – could be seen by otherwise admirable men and women as necessary, inevitable parts of a way of life that has many redeeming positive aspects. These apologists were wrapped in a set of perceptions – their “accepting slavery” paradigm – which prevented them from acknowledging the full awfulness of bound servitude. Despite their intelligence, their thinking was constrained. Despite the kindness that lay in their hearts, there were marked limits to their compassion.

Inhuman Bondage

I came across the work of David Brion Davis in the course of researching my own recently published book, The Abolition of Aging. Here’s an extract from near the end of my book:

The analysis by Davis makes it clear that:

  • The abolition of slavery was by no means inevitable or predetermined
  • There were strong arguments against the abolition of slavery – arguments raised by clever, devout people in both the United States and the United Kingdom – arguments concerning economic well-being, among many other factors
  • The arguments of the abolitionists were rooted in a conception of a better way of being a human – a way that avoided the harsh bondage and subjugation of the slave trade, and which would in due course enable many millions of people to fulfil a much greater potential
  • The cause of the abolition of slavery was significantly advanced by public activism – including pamphlets, lectures, petitions, and municipal meetings.

With its roots in the eighteenth century, and growing in momentum as the nineteenth century proceeded, the abolition of slavery eventually became an idea whose time had come – thanks to brave, smart, persistent activism by men and women with profound conviction.

With a different set of roots in the late twentieth century, and growing in momentum as the twenty-first century proceeds, the abolition of aging can, likewise, become an idea whose time has come. It’s an idea about an overwhelmingly better future for humanity – a future that will allow billions of people to fulfil a much greater potential. But as well as excellent engineering – the creation of reliable, accessible rejuvenation therapies – this project will also require brave, smart, persistent activism, to change the public landscape from one hostile (or apathetic) to rejuveneering into one that deeply supports it.

My claim in The Abolition of Aging is that most of us accept a terrible double think. We avidly support research against diseases such as cancer, dementia, and heart failure. We are aware of the destructive nature of all these diseases. But we shy away from research into the main underlying escalator of these diseases – the factor that makes these diseases more likely and (when they occur) more serious. This factor is biological aging – namely, the gradual deterioration of our molecular, cellular, and organic systems. We’re too ready to accept biological aging as a given.

We say it would be good if people could avoid being afflicted by cancer, dementia, or heart failure. We advocate people taking steps to decrease the chances of these diseases – for example, not to spend too much time under the direct sun, unprotected. But we tell ourselves that it’s somehow natural (and therefore somehow admirable) that biological aging accelerates in our bodies. So we acquiesce. We accept a deadly compromise.

The Abolition of Aging seeks to overturn that double think. It argues that rejuvenation is a noble, highly desirable, eminently practical destiny for our species – a “Humanity+” destiny that could, with sufficient focus and organisation, be achieved within just one human generation from now. Rejuvenation – the periodic reversal of the accumulation of significant damage at our molecular, cellular, and organic levels – can lead to a rapid decline in deaths from diseases of old age, such as cancer, dementia, heart failure, and lots more. Despite the implications of this change for our economic and social systems, this is an overwhelming good, which we should welcome wholeheartedly.

I’m happy to report that The Abolition of Aging has already featured as the #1 bestseller (in the UK) of the Gerontology section of Amazon.

Gerontology bestsellers UK

Next steps

Let’s return to the question from the start of this blogpost: In the grand sweep of history, how much difference can one person make?

We can’t all be Abraham Lincoln. But as I review in the final sections of my book, there’s a lot that each one of us can do, to tilt upwards the probability that successful rejuvenation therapies will be widely available by 2040. This includes steps to:

  1. Strengthen communities that are working on at least parts of the rejuveneering project
  2. Improve our personal understanding of aspects of rejuveneering – the science, roadmaps, history, philosophy, theories, personalities, platforms, open questions, and so on – and help to document aspects of that better understanding, by creating or editing knowledgebases or wikis
  3. Become involved with marketing of one sort or another
  4. Undertake original research into any of the unknowns of rejuveneering; this could be part of formal educational courses, or it could be a commercial R&D undertaking; it could also be part of a decentralised activity, in the style of “citizen science”
  5. Provide funding to projects that we judge to be particularly worthwhile.

Our contributions are likely to be more significant when they connect into positive efforts that others are already making. For example, I’m impressed by the activities of the Major Mouse Testing Program (MMTP), which you can read about here. I’ve just made a contribution to their crowdfunding campaign, and I encourage you to consider doing the same.

25 May 2016

The Abolition of Aging – epublished

TAoA Cover page v11

I’m happy to report that my new book was epublished today, for Amazon Kindle. It’s “The Abolition of Aging: The forthcoming radical extension of healthy human longevity”.

You can find it on Amazon US, Amazon UK, …

It’s not a book about reprogramming our (silicon-based) devices – the kind of thing that used to be on my mind in my smartphone industry days. Instead, it’s about reprogramming our biology.

My reasons for writing this book are contained in its foreword. For convenience, I append a copy of the foreword at the end of this blogpost.

Physical copies of the book should be available from some time next month, for readers who prefer atoms to bits. I am planning to create an audio version too.

You can find more details about the book on its own website:

  • Advance praise, from people who have read pre-publication copies
  • The book’s description and dedication
  • An expanded table of contents
  • A community page, for further information about topics covered in the book.

If anyone has comments or queries about anything they read in the book, they’re welcome to raise them as responses to this blogpost.

Foreword

(This content is part of the introductory material of the book “The Abolition of Aging”.)

Within our collective grasp dwells the remarkable possibility of the abolition of biological aging.

It’s a big “if”, but if we decide as a species to make this project a priority, there’s around a 50% chance that practical rejuvenation therapies resulting in the comprehensive reversal of aging will be widely available as early as 2040.

People everywhere, on the application of these treatments, will, if they wish, stop becoming biologically older. Instead, again if they wish, they’ll start to become biologically younger, in both body and mind, as rejuvenation therapies take hold. In short, everyone will have the option to become ageless.

Two objections

The viewpoint I’ve just described is a position I’ve reached following extensive research, carried out over more than ten years. My research has led me to become a strong supporter of what can be called “the rejuveneering project”: a multi-decade cross-disciplinary endeavour to engineer human rejuvenation and thereby enable the choice to abolish aging.

But when I mention this viewpoint to people that I meet – as part of my activity as a futurist, or when I catch up with my former colleagues from the smartphone industry – I frequently encounter one of two adverse reactions.

First, people tell me that it’s not possible that such treatments are going to exist in any meaningful timescale any time soon. In other words, they insist that human rejuvenation can’t be done. It’s wishful thinking to suppose otherwise, they say. It’s bad science. It’s naively over-optimistic. It’s ignorant of the long history of failures in this field. The technical challenges remain overwhelmingly difficult.

Second, people tell me that any such treatments would be socially destructive and morally indefensible. In other words, they insist that human rejuvenation shouldn’t be done. It’s essentially a selfish idea, they say – an idea with all kinds of undesirable consequences for societal harmony or planetary well-being. It’s an arrogant idea, from immature minds. It’s an idea that deserves to be strangled.

Can’t be done; shouldn’t be done – in this book, I will argue that both these objections are profoundly wrong. I’ll argue instead that rejuvenation is a noble, highly desirable, eminently practical destiny for our species – a “Humanity+” destiny that could be achieved within just one human generation from now. As I see it, the abolition of aging is set to take its place on the upward arc of human social progress, echoing developments such as the abolition of slavery, the abolition of racism, and the abolition of poverty.

It turns out that the can’t/shouldn’t objections are interlinked. They reinforce each other. It’s often because someone thinks an effort is technically impossible that they object to any time or finance being applied to it. It would be much better, they say, to apply these resources to other philanthropic causes where real progress is possible. That, allegedly, would be the moral, mature thing to do. Conversely, when someone’s moral stance predisposes them to accept personal bodily decline and death, they become eager to find technical reasons that back up their decision. After all, it’s human nature to tend to cherry pick evidence that supports what we want to believe.

Two paradigms

A set of mutually reinforcing interlinked beliefs is sometimes called a “paradigm”. Our paradigms guide us, both consciously and unconsciously, in how we see the world, and in the kinds of projects we deem to be worthwhile. Our paradigms filter our perceptions and constrain our imaginations.

Changing paradigms is hard work. Just ask anyone who has tried to alter the opinion of others on contentious matters such as climate change, gun control, regulating the free market, or progressive taxation. Mere reason alone cannot unseat opinions on such topics. What to some observers is clear and compelling evidence for one position is hardly even noticed by someone entrenched in a competing paradigm. The inconvenient evidence is swatted away with little conscious thought.

The paradigm that accepts human bodily decline and aging as somehow desirable has even deeper roots than the vexatious political topics mentioned in the previous paragraph. It’s not going to be easy to dislodge that accepting-agingparadigm. However, in the chapters ahead, I will marshal a wide range of considerations in favour of a different paradigm – the paradigm that heartily anticipates and endorses rejuvenation. I’ll try to encourage readers to see things from that anticipating-rejuvenation paradigm.

Two abolitions

Accepting aging can be compared to accepting slavery.

For millennia, people from all social classes took slavery for granted. Thoughtful participants may have seen drawbacks with the system, but they assumed that there was no alternative to the basic fact of slavery. They could not conceive how society would function properly without slaves. Even the Bible takes slavery as a given. There is no Mosaic commandment which says “Thou shalt not keep slaves”. Nor is there anything in the New Testament that tells slave owners to set their slaves free.

But in recent times, thank goodness, the public mind changed. The accepting-slavery paradigm wilted in the face of a crescendo of opposing arguments. As with slavery, so also with aging: the time will come for its abolition. The public will cease to take aging for granted. They’ll stop believing in spurious justifications for its inevitability. They’ll demand better. They’ll see how rejuvenation is ready to be embraced.

One reason why slavery is so objectionable is the extent of its curtailment of human opportunity – the denial of free choice to the people enslaved. Another reason is that life expectancy of slaves frequently fell far short of the life expectancy of people not enslaved. As such, slavery can be counted as a major killer: it accelerated death.

From the anticipating-rejuvenation perspective, aging should be seen as the biggest killer of all. Compared to “standard” killers of the present day, such as drunken driving, terrorism, lead fumes, or other carcinogens – killers which rouse us to action to constrain them – aging destroys many more people. Globally, aging is the cause of at least two thirds of human deaths. Aging is the awful elephant in the room, which we have collectively learned to ignore, but which we must learn to recognise and challenge anew.

Every single week the rejuveneering project is delayed, hundreds of thousands more people suffer and die worldwide due to aging-related diseases. Advocates of rejuveneering see this ongoing situation as a needless slaughter. It’s an intolerable offence against human potential. We ought, therefore, to be powerfully motivated to raise the probability of 50% which I offered at the start of this foreword. A 50% chance of success with the rejuveneering project means, equally, a 50% chance of that project failing. That’s a 50% chance of the human slaughter continuing.

Motivation

In the same way as we have become fervently motivated in recent decades to deal with the other killers mentioned above – vigorously campaigning against, for example, drunk drivers and emitters of noxious chemical pollutants – we ought to be even more motivated to deal with aging. The anger that society has directed against tobacco companies, for long obscuring the links between smoking and lung cancer, ought to find a resonance in a new social passion to uncover and address links between biological aging and numerous diseases. If it’s right to seek to change behaviours and metabolism to cut down bad cholesterol (a precursor of heart disease) and concentrated glucose (a precursor of diabetes), it should be equally right to change behaviours and metabolism to cut down something that’s a precursor of even more diseases, namely, biological aging.

This is a discussion with enormous consequences. Changes in the public mood regarding the desirability of rejuveneering could trigger large reallocations of both public and private research expenditure. In turn, these reallocations are likely to have major implications in many areas of public well-being. Clearly, these decisions need to be taken wisely – with decisions being guided by a better understanding of the rich landscape of rejuveneering possibilities.

An ongoing surge of motivation, wisely coordinated, is one of the factors which can assist the rejuveneering project to overcome the weighty challenges it faces – challenges in science, technology, engineering, and human collaboration. Stubborn “unknown unknowns” surely lie ahead too. Due to these complexities and unknowns, no one can be sure of the outcome of this project. Despite what some rejuvenation enthusiasts may suggest, there’s nothing inevitable about the pace of future medical progress. That’s why I give the probability of success as only around 50%.

Although the end outcome remains unclear, the sense of discovery is increasing. The underlying scientific context is changing rapidly. Every day brings its own fresh firehose of news of potential breakthrough medical approaches. In the midst of so much innovation, it behoves us to seek clarity on the bigger picture.

To the extent that my book can provide that bigger picture, it will have met at least some of its goals. Armed with that bigger picture, readers of this book will, hopefully, be better placed to find the aspect of the overall rejuveneering project where they can make their best contributions. Together, we can tilt that 50% success probability upwards. The sooner, the better.

(If you found this interesting, you may like to read “The discussion ahead” next.)

 

19 September 2014

The new future of old age

In an enchanting four minute video, Korean artist Seok Jeong Hyeon, who is also known as Stonehouse, portrays the gradual aging of a baby girl. At first, the changes are slow, but they accumulate as years and then decades pass. The end result is an elderly woman, adorned with lines and wrinkles, who finally stops breathing.

The video is beautiful, and the woman maintains her own elegance to the end. As such, it presents a romantic view of aging. (And the video even hints at another romantic idea, namely reincarnation.)

In reality, as we age, we suffer from increasing numbers of aches and pains. We half-laugh when we say that we’re experiencing a “senior moment” of forgetfulness, but we notice our declining potency. Worse, every extra eight years that we live, past the age of around 35, we become twice as likely to die within the next year. In other words, our mortality rate increases exponentially. This was first observed in 1825 by British actuary and mathematician Benjamin Gompertz. Empirical data continues to support Gompertz, nearly two centuries later. For example, here’s a chart of the exponentially increasing death rate in the USA:

gompertz-mortality-curve

One of the factors underlying this upwards surge of mortality rate is the fact that, as we become older, we become increasingly vulnerable to various horrible diseases, such as cancer, heart disease, diabetes, Alzheimer’s, and lung disorders. Aging researcher Avi Roy of Oxford has collected information from the Office of National Statistics as follows:

Death rates from diseases

These five diseases aren’t random choices, by the way. They’re currently all high up in the list of the current largest causes of death.

The romantic notion of death is that we grow old gracefully, lose our powers almost imperceptibly, and die in our sleep, contented, surrounded by happy thoughts. In all too many cases, alas, death is preceded by viciously nasty diseases.

The Palo Alto prize

One of the deeply cherished visions of potential human progress has been the hope that, one day, we could reverse this state of affairs. Instead of the rate of mortality increasing with chronological age, it could remain constant. The terrible diseases listed, and others like them, which all currently increase their impact the older we get, could be conquered by the development of medicine – much the same as medicine has already made huge inroads against infectious diseases. The best solution would be, not a wide range of individual interventions each targeted at specific diseases, but an intervention that undoes the underlying damage of aging – the damage which accumulates throughout our body, and which makes it more likely that we fall prey to “diseases of old age”.

Until recently, that vision has lain well outside scientific orthodoxy. People have been loath to mention the idea, as it could spell the end of their academic careers.

However, that reticence seems to be changing. No less than eleven research teams from universities around the world have already publicly committed to entering for the recently announced “Palo Alto Longevity Prize”, which has a $1M prize fund. This video provides an introduction to the prize:

This video introduces key personnel from the different teams who are already engaged in developing solutions for contest:

.

The eleven teams and their leaders are listed in a recent TechCrunch article about the prize:

Doris Taylor, Ph.D.
Texas Heart Institute, Houston, TX
http://paloaltoprize.com/team/team-taylor-lab/ ‎
TEAM NAME: T.H.I. REGENERATIVE MEDICINE (approach: stem cells)

Dongsheng Cai, M.D., Ph.D.
Albert Einstein College of Medicine, New York, NY
http://paloaltoprize.com/team/cai-lab/
TEAM NAME: CAI LAB (approach: hypothalamic regulation)

Andreas Birkenfeld, M.D.
Charite University School of Medicine, Berlin, Germany
http://paloaltoprize.com/team/team-indy/
TEAM NAME: INDY (approach: gene modification)

Jin Hyung Lee, Ph.D.
Stanford University, Palo Alto, CA
http://paloaltoprize.com/team/team-lee-lab/
TEAM NAME: LEE LAB (approach: neuromodulation)

David Mendelowitz, Ph.D.
George Washington University, Washington, D.C.
http://paloaltoprize.com/team/team-mendelowitz-lab/
TEAM NAME: MENDELOWITZ LAB (approach: oxytocin)

Scott Wolf, M.D.
Mountain View, CA
http://paloaltoprize.com/team/volts-medical/
TEAM NAME: VOLTS MEDICAL (approach: inflammatory tissues)

Irving Zucker, Ph.D.
University of Nebraska Medical Center, Omaha, NE
http://paloaltoprize.com/team/team-zucker-lab/
TEAM NAME: ZUCKER LAB (approach: neuromodulation)

Brian Olshansky, M.D.
University of Iowa Medical Center, Iowa City, IA
http://paloaltoprize.com/team/team-olshansky-lab
TEAM NAME: IOWA PRO-AUTONOMIA (approach: not yet public)

William Sarill, M.A.
Arlington, MA
http://paloaltoprize.com/team/team-sarill-lab/
TEAM NAME: DECO (approach: pituitary hormones)

Steven Porges, Ph.D.
University of North Carolina, Chapel Hill, NC
http://paloaltoprize.com/team/team-porges-lab/
TEAM NAME: POLYVAGAL SCIENCE (approach: optimizing both the left & right vagal branches)

Shin-Ichiro Imai, M.D., Ph.D.
Washington University, St. Louis, MO
http://paloaltoprize.com/team/imai-lab/
TEAM NAME: IMAI LAB (approach: gene modification)

Approaching rejuvenation

AR Cover page v2In the light of all the fascinating developments around the field of increasing healthy longevity, I’ve decided that my next book will focus on that field.

The book is entitled “Approaching rejuvenation: Is science on the point of radically extending human longevity”. My intent is that the book will provide a bird’s eye report from the frontiers of the emerging field of rejuvenation biology:

  • The goals and motivations of key players in this field
  • The rapid progress that has been achieved in the last few years
  • The challenges that threaten to thwart further development
  • The critical questions that need to be faced.

The book will be based around material from interviews with more than a dozen researchers, engineers, entrepreneurs, and humanitarians, who are making it their life’s quest to enable human rejuvenation. I’ve already started doing these interviews.

I’m far from being an expert in any branch of biochemistry or medicine. However, I hope to bring five important angles to this writing task:

  1. My background in history and philosophy of science, wrestling with the question of how to distinguish science from pseudoscience, and the more general dilemma of how to decide whether lines of research are likely to turn out to be misguided dead-ends
  2. My professional career within the smartphone industry, where I saw a lot of similar aspirations (though on a much smaller scale) regarding the breakthroughs that fast-moving technology could enable
  3. My experience as a writer, in which I seek to explain complicated subjects in a relatively straightforward but engaging manner
  4. The six years in which I have had the privilege to organise meetups in London dedicated to futurist, singularitarian, and technoprogressive topics – meetings which have featured a wide variety of different attitudes and outlooks
  5. My aspiration as a humanitarian to probe for both the human upsides and the human downsides of changing technology – in order to set possible engineering breakthroughs (such as rejuvenation biotech) in a broader societal context.

If you have any suggestions or comments about this new book project, please don’t hesitate to get in touch.

The new future of old age

The London Futurists event next Saturday (27th September) addresses the same general theme. I close this blogpost with an excerpt from the description of the meetup. Please see the associated meetup page for more information about the speakers, for logistics details, and to register to attend. I hope to see some of you there!

Futurists, life extension advocates, transhumanists and others have been speaking for several decades already about the possibility, desirability, and broader consequences of significantly extending the human healthy lifespan. In this vision, the deteriorating effects of infirmity and old age could be radically postponed, and perhaps abolished altogether, via improvements in regenerative biotechnology.

Forget “70 is the new 50”. We might have the possibility of “150 is the new 50”. And alongside the existing booming cosmetics industry, with huge amounts spent to reduce the visible signs of aging, we might envision a booming rejuvenation industry, reversing the actual underlying biochemical damage that constitutes aging.

Recently, the pace of change in the field of healthy life extension seems to have increased: almost every day there are reports of possible breakthrough treatment methods, unexpected experimental results, new economic analyses of demographic changes, and innovative theoretical ideas. It’s hard to keep up with all these reports.

How can we evaluate this flurry of change?

Held in conjunction with the UN International Day of Older People (which occurs each year on 1st October), this event brings together a panel of expert speakers – William BainsMichael Price, Alex Zhavoronkov, and Sebastian Sethe – who will each give their assessment of “what’s new in the field of old age”:

  • What are some of the most significant research findings and other potential breakthroughs from the last five years?
  • What is the likelihood of significant practical change in healthy longevity within, say, the next 10-20 years?
  • What would be the economic, social, and psychological implications of such changes?
  • Are there any new grounds for scepticism or fear regarding these potential changes?
  • If individuals wish to help accelerate these changes, what should they do?
  • What are the major obstacles that could prevent real progress being made?

FB meeting image

 

 

16 April 2014

The future of healthy longevity life extension

There’s a great deal of news these days about potential developments to increase healthy longevity. How can we decide which are the most promising initiatives? What can we do to support faster development and deployment of new treatments? If we want to enable significant increases in healthy longevity for ourselves and our loved ones, what steps should we be taking?

This whole subject – healthy longevity – is complicated by the fact that it’s clouded by a great deal of wishful thinking and misinformation (some deliberate, some unintentional). Companies have products and services they wish to promote. Whole industries have worldviews that they want to maintain. People have engrained personal habits that they wish to justify and rationalise.

And did I mention wish-fulfilment? Here’s an evocative picture posted recently by Vincent Ocasla, a healthy longevity advocate:

Anti-aging

(This picture has an interesting provenance. See the footnote at the end of this blogpost.)

Who, if they were honest, would not like to grasp the possibility of the kind of healthy age-reversal depicted here, if it could be provided ethically, for them and their loved ones? But what steps should we take, that would be most likely to accelerate the enablement of such a transformation?

Back in September last year, I organised a London Futurists “Hangout On Air” video event on that topic. This featured as panellists a number life extension activists from around the world – Franco Cortese, Ilia Stambler, Maria Konovalenko, and Aubrey de Grey. You can see the outcome here:

That ninety minute discussion covered a lot of important topics, but it’s far from providing the last word on the matter. To help continue the discussion, I’m holding an “in real life” London Futurists meetup on the afternoon of Saturday 26th April in Birkbeck College, central London. There will be a number of TED-style talks, followed by extended audience Q&A and discussion.

See here for more details about this event – and to RSVP if you’re planning to attend (this helps me to organise it smoothly) .

Meeting Image

The speakers are Phil MicansTuvi Orbach, and Avi Roy. They each have fascinating and well-informed things to say about the subject. I expect those of us in the audience will all be individually challenged and inspired, at various times in this meetup, to rethink our own personal health strategies, and/or to alter our thinking about how to change society’s presently inadequate approach to this topic.

Phil Micans is Founder and Vice President of International Antiaging Systems and Assistant Director at the British Longevity Society.

Phil has been actively involved in the antiaging field since the late 1980’s. He is currently the Editor-in-Chief of the Aging Matters™ Magazine, Chairman of the Monte Carlo Antiaging Congress, and Assistant Editor to the Lifespan Medicine Journal. He holds a masters degree in biochemistry from Canterbury.

Phil will talk about why orthodox medicine must change its approach to longevity, and the need for preventative and regenerative medicine.

His lecture will review data as issued by the US, UK and WHO authorities. It will become clear that ‘orthodox’ medicine cannot continue as-is for much longer and that a different path will need to be taken soon. The talk will also introduce the concept of the optimal health pyramid.

Tuvi Orbach is the chairman of Mindlife UK, and Managing Trustee of HELP Trust – a charity with the purpose to help and inspire people to enhance their lives.

Tuvi has a background as an entrepreneur who has established several companies integrating software, technology and “lifeware”. Products and services provided  by his companies include:

  • An interactive self-help application to cure anxiety and depression
  • Computerised health screening and prevention for long-term conditions.

Tuvi will address combining the use of technology for self-help with better internal (mind-body, optimism etc) and external lifestyle modification. He’ll also talk about the integration of new science with traditional wisdom.

Avi Roy is is a PhD student researching biomarkers of aging, mitochondria, and regenerative medicine at the Institute of Translational Medicine, Buckingham.

Avi currently writes for The Conversation and has previously written for The Guardian. His articles have also been published in the New Statesman and Business Insider.

Avi also heads up the Oxford University Scientific Society, the Oxford Transhumanism and Emerging Technologies society, and organizes talks at the British Science Association Oxford branch.

Footnotes:

The above 2014->2063 transformation picture has been adapted from (you guessed it) a similar one which portrayed the transformation in the opposite direction, 1963->2014. That earlier version was published in the Twitter stream for “History in Pictures”. So there’s at least one round of “cosmetic retouching” that has taken place. The online comments for the earlier picture suggest that it has been “faked” too.

Of course, the whole point is to find out what kind of rejuvenation technology (sometimes called “rejuveneering”) is possible, without the subterfuge of Photoshop or similar. I’ll be picking up that theme in a talk I’m giving at the Symposium of the Society of Cosmetic Scientists on May 1st. That Symposium has the theme “Face the future”. My  talk there is the closing keynote, ‘More than skin deep: radical options for human transformation, 2015-2045’:

Vision: Within 30 years, those of us still alive will have the potential to experience profound human enhancement. Detox and rejuvenation therapies that clean out internal biological damage will be able to revitalise us in far-reaching ways. Smartphone technology will be miniaturised and ready for incorporation deep inside our bodies and brains. We’ll be living alongside enchanting, witty robots and other forms of super AIs and virtual companions, who will have deprived most of us of gainful employment. We might even be on the point of merger: human with robot, biology with technology.

But which elements of this vision are science fiction, and which science fact? What factors influence the acceleration of technology? And how can we collectively mould the trajectories ahead, so that human values flourish, rather than us bitterly regretting what we allowed to happen?

17 September 2013

When faith gets in the way of progress

Is it good that we grow old, weak, disease-prone, and eventually succumb, dead, to the ravages of aging?

The rise and fall of our health and vigour is depicted in this sketch from leading biogerontology researcher Alex Zhavoronkov:

Aging Decline

This diagram is taken from the presentation Alex made at a London Futurists event on 31st August. Alex used the same slide in his presentation, several days later, to the SENS6 conference “Reimage aging” at Queens’ College, Cambridge.

conf-page-banner

My impression from the attendees at SENS6 that I met, over the four days I spent at the conference, is that the vast majority of them would give a resounding ‘No’ as the answer to the question,

Is it good that we grow old, weak, disease-prone, and eventually succumb, dead, to the ravages of aging?

What’s more, they shared a commitment that action should be taken to change this state of affairs. In various ways, they described themselves as “fighters against aging”, “healthy longevity activists”, and as “campaigners for negligible senescence”. They share an interest in the declaration made on the page on the SENS Research Foundation website describing the conference:

The purpose of the SENS conference series, like all the SENS initiatives, is to expedite the development of truly effective therapies to postpone and treat human aging by tackling it as an engineering problem: not seeking elusive and probably illusory magic bullets, but instead enumerating the accumulating molecular and cellular changes that eventually kill us and identifying ways to repair – to reverse – those changes, rather than merely to slow down their further accumulation.

This broadly defined regenerative medicine – which includes the repair of living cells and extracellular material in situ – applied to damage of aging, is what we refer to as rejuvenation biotechnologies.

This “interventionist” approach, if successful, would lead to a line, on the chart of performance against age, similar to that shown in the bright green colour: we would retain our youthful vigour indefinitely. Mechanisms supporting this outcome were explored in considerable technical details in the SENS6 presentations. The SENS6 audience collectively posed some probing questions to the individual presenters, but the overall direction was agreed. Rejuvenation biotechnologies ought to be developed, as soon as possible.

But not everyone sees things like this. SENS6 attendees agreed on that point too. Over informal discussions throughout the event, people time and again shared anecdotes about their personal acquaintances being opposed to the goals of SENS. You can easily see the same kind of negative reactions, in the online comments pages of newspapers, whenever a newspaper reports some promising news about potential techniques to overcome aging.

For example, the Daily Mail in the UK recently published a well-researched article, “Do lobsters hold the key to eternal life? Forget gastronomic indulgence, the crustacean can defy the aging process”. The article starts as follows:

They are usually associated with a life of gastronomic indulgence and heart-stopping excess. But away from the dinner table, lobsters may actually hold the secret to a long, healthy — and possibly even eternal — life.

For this crustacean is one of a handful of bizarre animals that appear to defy the normal aging process.

While the passing years bring arthritis, muscle loss, memory problems and illness to humans, lobsters seem to be immune to the ravages of time. They can be injured, of course. They can pick up diseases. They can be caught and thrown into a pot, then smothered in béchamel sauce.

But rather than getting weaker and more vulnerable over the years, they become stronger and more fertile each time they shed their shells.

The typical lobster weighs 1 to 2 lb. But in 2009, a Maine fisherman landed a colossus of 20 lb, which was estimated to be 140 years old. And that isn’t even the oldest lobster found so far. According to Guinness World Records, a 44 lb leviathan was caught in 1977, with claws powerful enough to snap a man’s arm.

The species belongs to an elite group that appears to be ‘biologically immortal’. Away from predators, injury or disease, these astonishing creatures’ cells don’t deteriorate with age…

For healthy longevity activists, there was lots of good news in the article. This information, however, was too much for some readers to contemplate. Some of the online comments make for fascinating (but depressing) reading. Here are four examples, quoted directly from the comments:

  1. How would humankind cope with tens of millions of extremely old and incredibly crabby people?
  2. People have to die and they’re not dying quickly enough. Soon the earth will run out of water and food for the ever increasing masses.
  3. These “researchers” should watch Death Becomes Her
  4. The only guarantee of eternal life is to read your Bibles. Though even if you don’t, eternal life of another kind exists, though it’s not particularly appealing: “And the smoke of their torment ascendeth up for ever and ever” (Rev 14:11).

To be clear, the goal of project such as those in the SENS umbrella is to extend healthy lifespans (sometimes known as “healthspans”) rather than simply extending lifespans themselves. Rejuvenation technologies are envisioned to undo tendencies towards unwelcome decrepitude, crabbiness, and so on.

As for the reference to the 1992 Hollywood film “Death Becomes Her” featuring Meryl Streep and Goldie Hawn in a frightful “living dead” immortality, I’ll get back to that later.

Infinite ResourceThe question of potential over-population has a bit more substance. However, the worry isn’t so much the number of people on the earth, but the rate at which everyone is consuming and polluting. With potential forthcoming improvements in harnessing solar energy, we’ll have more than enough energy available to look after a planet with 10 billion people. Arguably the planet could sustain at least 100 billion people. (That argument is made, in a well-balanced way, by Ramez Naam in his recent book “The infinite resource” – a book I thoroughly recommend. I’ve also covered this question from time to time in earlier blogposts – see e.g. “Achieving a 130-fold improvement in 40 years”.)

However, I believe that there are deeper roots to the opposition that many people have to the idea of extending healthy lifespans. They may offer intellectual rationalisations for their opposition (e.g. “How would humankind cope with tens of millions of extremely old and incredibly crabby people?”) but these rationalisations are not the drivers for the position they hold.

Instead, their opposition to extending healthy lifespans comes from what we can call faith.

This thought crystallised in my mind as I reflected on the very last presentation from SENS6. The speaker was Thomas Pyszczynski of the University of Colorado, and his topic was “Understanding the paradox of opposition to long-term extension of the human lifespan: fear of death, cultural worldviews, and the illusion of objectivity”.

The presentation title was long, but the content was clear and vivid. The speaker outlined some conclusions from decades of research he had conducted into “Terror Management Theory (TMT)”. I’ve since discovered that the subject of “Terror Management Theory” has its own article in Wikipedia:

Terror management theory (TMT), in social psychology, proposes a basic psychological conflict that results from having a desire to live but realizing that death is inevitable. This conflict produces terror, and is believed to be unique to humans. Moreover, the solution to the conflict is also generally unique to humans: culture. According to TMT, cultures are symbolic systems that act to provide life with meaning and value. If life is thought meaningful, death is less terrifying. Cultural values therefore serve to manage the terror of death by providing life with meaning…

pyszczynski

Here’s the “paradox” to which Pyszczynski (pictured) referred: people oppose the idea that we could have longer healthy lives, because of the operation of a set of culture and philosophical ideas, which were themselves an adaptive response to the underlying fact that we deeply desire indefinitely long healthy lives. So the opposition is self-contradictory, but the people involved don’t see it like that.

For all of history up until the present age, the idea of having an indefinitely long healthy life was at stark variance to everything else that we saw around ourselves. Death seemed inevitable. In order to avoid collapsing into terror, we needed to develop rationalisations and techniques that prevented us from thinking seriously about our own finitude and mortality. That’s where key aspects of our culture arose. These aspects of our culture became deeply rooted.

Our culture operates, in many cases, below the level of conscious awareness. We find ourselves being driven by various underlying beliefs, without being aware of the set of causes and effects. However, we find comfort in these beliefs. This faith (belief in the absence of sufficient reason) helps to keep us mentally sane, and keeps society functional, even as it prepares us, as individuals, to grow infirm and die.

In case any new ideas challenge this faith, we find ourselves compelled to lash out against these ideas, even without taking the time to analyse them. Our motivation, here, is to preserve our core culture and faith, since that’s what provides the foundation of meaning in our lives. We fight the new ideas, even if these new ideas would be a better solution to our underlying desire to live an indefinitely long, healthy life. The new ideas leave us with a feeling of alienation, even though we don’t see the actual connections between ideas. Our faith causes us to lose our rationality.

Incidentally, similar factors apply, of course, when other things that have profound importance to us are challenged. For example, when we think we may lose a cherished romantic partner, we can all too easily become crazy. When your heart’s on fire, smoke gets in your eyes.

Ending AgingIt turns out that Aubrey de Grey, the chief science officer of SENS, has already written on this same topic. In chapter two of his 2007 book “Ending aging”, he notes the following:

There is a very simple reason why so many people defend aging so strongly – a reason that is now invalid, but until quite recently was entirely reasonable. Until recently, no one has had any coherent idea how to defeat aging, so it has been effectively inevitable. And when one is faced with a fate that is as ghastly as aging and about which one can do absolutely nothing, either for oneself or even for others, it makes perfect psychological sense to put it out of one’s mind – to make one’s peace with it, you might say – rather than to spend one’s miserably short life preoccupied by it. The fact that, in order to sustain this state of mind, one has to abandon all semblance of rationality on the subject – and, inevitably, to engage in embarrassingly unreasonable conversational tactics to shore up that irrationality – is a small price to pay….

Aubrey continues this theme at the start of chapter three:

We’ve recently reached the point where we can engage in the rational design of therapies to defeat aging: most of the rest of this book is an account of my favoured approach to that design. But in order to ensure that you can read that account with an open mind, I need to dispose beforehand of a particularly insidious aspect of the pro-aging trance: the fact that most people already know, in their heart of hearts, that there is a possibility that aging will eventually be defeated.

Why is this a problem? Indeed, at first sight you might think that it would make my job easier, since surely it means that the pro-aging trance is not particularly deep. Unfortunately, however, self-sustained delusions don’t work like that. Just as it’s rational to be irrational about the desirability of aging in order to make your peace with it, it’s also rational to be irrational about the feasibility of defeating aging while the chance of defeating it any time soon remains low. If you think there’s even a 1 percent chance of defeating aging within your lifetime (or within the lifetime of someone you love), that sliver of hope will prey on your mind and keep your pro-aging trance uncomfortably fragile, however hard you’ve worked to convince yourself that aging is actually not such a bad thing after all. If you’re completely convinced that aging is immutable, by contrast, you can sleep more soundly.

Underwood_Mair_2013_smallAnother speaker from the final session of SENS6, Mair Underwood of the University of Queensland, provided some timely advice to the SENS6 community, that dovetails well with the discussion above. Underwood’s presentation was entitled “What reassurances do the community need regarding life extension? Evidence from studies of community attitudes and an analysis of film portrayals”. The presentation pointed out the many ways in which popular films (such as “Death Becomes Her”, mentioned above) portray would-be life extensionists in a bad light. These people, the films imply, are emotionally immature, selfish, frustrated, obstructive, and generally unattractive. This is the pro-death culture at work.

To counteract these impressions, and to help free the broader community from its faith that aging and death are actually good things, Underwood gave the following advice:

  1. Assure that life extension science, and the distribution of life extension technologies, are ethical and regulated, and seen to be so
  2. Assuage community concerns about life extension as unnatural or playing god
  3. Assure that life extension would involve an extension of healthy lifespan
  4. Assure that life extension does not mean a loss of fertility
  5. Assure the community that life extension will not exacerbate social divides, and that those with extended lives will not be a burden on society
  6. Create a new cultural framework for understanding life extension.

This advice is all good, but I suspect that the new few years may see a growing “battle of faiths”, as representatives of the old culture fight harder in opposition to the emerging evidence that we we are on the point of possessing the technological means to extend human healthspans very significantly. This is a battle that may need more tools, to influence the outcome, than mere hard-honed rationality. At the very least, we’ll need to keep in mind how culture works, and the ways in which faith draws strength.

Follow ups: Several forthcoming London Futurists meetups address topics that are directly relevant to the above line of thinking:

  • Futurism, Spirituality, and Faith, in Birkbeck College on Saturday 21st September, discusses ways in which committed technoprogressives can best interact with faith-based movements, without these interactions leading to fruitless irrationality and loss of direction
  • Projects to accelerate radical healthy longevity, a Google Hangout On Air (HOA) on Sunday 29th September, features a panel discussion on the question, “What are the most important ongoing projects to accelerate radical healthy longevity?”
  • Futurists discuss The Transhumanist Wager, with Zoltan Istvan, another Google HOA, on Sunday 20th September, reviews a recently published novel about a possible near-future scenario of a growing battle between the old human culture and an emerging new culture that favours indefinitely long healthspans.
  • Finally, if you’re interested in the question of whether solar energy will be able, as I implied above, to address pending shortages in global energy supplies, even as human population continues to increase, you should make it a priority to attend the London Futurists event on Saturday 5th October, The Energy of Nations, with Jeremy Leggett. The speaker on this occasion is one of the world’s foremost authorities on solar energy, oil depletion, climate change, and dysfunctional investment. The topic of the best energy systems for the decades ahead is, alas, another one in which faith tends to subvert reason, and in which we need to be smart to prevent our thinking being hijacked by adverse factors.

For more information about the evolution of London Futurists, you can take a peek at a new website which is in the process of being implemented, at http://londonfuturists.com/.

19 August 2013

Longevity and the looming financial meltdown

Filed under: aging, books, challenge, converged medicine, Economics, futurist, healthcare, rejuveneering, SENS — David Wood @ 2:12 pm

What kind of transformational infrastructure investment projects should governments prioritise?

In the UK, government seems committed to spending a whopping £42 billion between now and 2032 on a lengthy infrastructure project, namely the “HS2” High Speed rail link which could see trains travelling between London, Birmingham, and six other cities, at up to 250 miles per hour. The scheme has many critics. As Nigel Morris notes in The Independent,

In an analysis published today (Monday), the IEA (Institute for Economic Affairs ) says the scheme’s cost has been vastly underestimated and had failed to take into account changes to routes and extra tunnelling because of local opposition.

Richard Wellings, its author, said: “The evidence is now overwhelming that this will be unbelievably costly to the taxpayer while delivering incredibly poor value for money.”

Supporters of this investment claim that the improved infrastructure will be a boon for business in the UK. Multi-year infrastructure improvement projects are something that the private sector tends not to attempt. Unless there’s coordination from government, this kind of project will not happen.

The BBC news website (here and here) helpfully listed ten alternative infrastructure improvement projects that might be better recipients of portions of the £42B earmarked for HS2. Suggestions include:

  • A new road motorway for the east of Britain
  • A bridge to the Isle of Wight
  • A new Channel tunnel, directly accessible to car drivers
  • Tram systems for Liverpool and Leeds
  • A tunnel between Great Britain and Ireland
  • Aerial cycle highways for London

If it were my decision, I would reallocate a large chunk of this funding to a different kind of multi-year infrastructure improvement project. This is in the area of health rather than the area of transport. The idea is to significantly promote research and deployment of treatments in preventive and regenerative medicine.

Ageless CoverThe argument for this kind of sustained investment is laid out in the book The Ageless Generation: How Advances in Biomedicine Will Transform the Global Economy, by Alex Zhavoronkov, which I’ve just finished reading. It’s a compelling analysis.

Alex will be sharing his views at a forthcoming meeting of the London Futurists, on Saturday 31st July. There are more details of this meeting here. (Note that a number of copies of the speaker’s book will be available free of charge to attendees of this meeting.)

The book contains many eye-opening pointers to peer-reviewed research. This covers the accelerating pace of medical breakthroughs, in areas such as bioartificial organs, stem cell therapies, repairing damaged tissues, fortifying the immune system, and autophagy. The research also covers financial and economic matters.

For example, here’s a snippet from the 2009 report “The Burden of Chronic Disease” (PDF) – which is written from a US point of view, though the implications apply for other countries too:

Our current economic reality reminds us that now more than ever, we need to invest in the backbone of our economy: the American workforce. Without question, the single biggest force threatening U.S. workforce productivity, as well as health care affordability and quality of life, is the rise in chronic conditions…

Further into that report, data is quoted from the Milken Institute report “The Economic Burden of Chronic Disease” (PDF)

By our calculations, the most common chronic diseases are costing the economy more than $1 trillion annually—and that figure threatens to reach $6 trillion by the middle of the century.

The costs include lost of productivity, as well as absenteeism:

The potential savings on treatment represents just the tip of the proverbial iceberg. Chronically ill workers take sick days, reducing the supply of labor—and, in the process, the GDP. When they do show up for work to avoid losing wages, they perform far below par—a circumstance known as “presenteeism,” in contrast to absenteeism. Output loss (indirect impacts) due to presenteeism (lower productivity) is immense—several times greater than losses associated with absenteeism. Last (but hardly a footnote), avoidable illness diverts the productive capacity of caregivers, adding to the reduction in labor supply for other uses. Combined, the indirect impacts of these diseases totaled just over $1 trillion in 2003…

In his book, Alex builds on this analysis, focussing on the looming costs to healthcare systems and pensions systems of ever greater portions of our population being elderly and infirm, and becoming increasingly vulnerable to chronic illnesses. Countries face bankruptcy on account of the increased costs. At the very least, we must expect radical changes in the provision of social welfare. The pensionable age is likely to rocket upwards. Families are likely to discover that the provisions they have made for their old age and retirement are woefully inadequate.

The situation is bleak, but solutions are at hand, through a wave of biomedical innovation which could make our recent wave of IT innovation look paltry in comparison. However, despite their promise, these biomedical solutions are arriving too slowly. The healthcare and pharmaceutical industries are bringing us some progress, but they are constrained by their own existing dynamics.

Alex_cover_2_smallAs Alex writes,

The revolution in information technology has irreversibly changed our lives over the past two decades. However, advances in biomedicine stand poised to eclipse the social and economic effects of IT in the near future.

Biomedical innovations typically reach the mass market in much slower fashion than those from information technology. They follow a paradigm where neither demand, in the form of the consumer, nor supply, in the form of the innovator, can significantly accelerate the process. Nevertheless, many of the advances made over the past three decades are already propagating into mainstream clinical practice and converging with other technologies extending our life spans.

However, in the near-term, unless the governments of the debt-laden developed countries make proactive policy changes, there is a possibility of lengthy economic decline and even collapse.

Biomedical advances are not all the same. The current paradigm in biomedical research, clinical regulation and healthcare has created a spur of costly procedures that provide marginal increases late in life extending the “last mile”, with the vast percentage of the lifetime healthcare costs being spent in the last few years of patient’s life, increasing the burden on the economy and society.

There is an urgent need to proactively adjust healthcare, social security, research and regulatory policies:

  • To ameliorate the negative near-term effects
  • To accelerate the mass adoption of technologies contributing positively to the economy.

Now that’s a project well worth spending billions on. It’s a vision of expanded healthspans rather than just of expanded lifespans. It’s a vision of people continuing to be happily productive members of society well into their 80s and 90s and beyond, learning new skills, continuing to expand their horizons, whilst sharing their wisdom and experience with younger generations.

It’s a great vision for the individuals involved (and their families), but also a great vision for the well-being of society as a whole. However, without concerted action, it’s unlikely to become reality.

Footnote 1: To connect the end of this line of reasoning back to its start: If the whole workforce remains healthy, in body, mind, and spirit, for many years more than before, there will be plenty of extra resources and skills available to address problems in other fields, such as inadequate traffic vehicle infrastructure. My own preferred approach to that particular problem is improved teleconferencing, virtual presence, avatar representation, and other solutions based on transporting bits rather than transporting atoms, though there’s surely scope for improved physical transport too. Driverless vehicles have a lot of promise.

Footnote 2: The Lifestar Institute produced a well-paced 5 minute video, “Can we afford not to try?” covering many of the topics I’ve mentioned above. View it at the Lifestar Institute site, or, for convenience, embedded below.

Footnote 3: The Lifestar Institute video was shown publicly for the first time at the SENS4 conference in Cambridge in September 2009. I was in the audience that day and vividly remember the impact the video made on me. The SENS Foundation is running the next in their series of biennial conferences (“SENS 6”) this September, from the 3rd to the 7th. The theme is “Reimagine aging”. I’m greatly looking forward to it!

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31 December 2010

Welcome 2011 – what will the future hold?

Filed under: aging, futurist, Humanity Plus, intelligence, rejuveneering — David Wood @ 6:42 pm

As 2010 turns into 2011, let me offer some predictions about topics that will increasingly be on people’s minds, as 2011 advances.

(Spoiler: these are all topics that will feature as speaker presentations at the Humanity+ UK 2011 conference that I’m organising in London’s Conway Hall on 29th January.  At time of writing, I’m still waiting to confirm possibly one or two more speakers for this event, but registration is already open.)

Apologies for omitting many other key emerging tech-related trends from this list.  If there’s something you care strongly about – and if you live within striking distance of London – you’ll be more than welcome to join the discussion on 29th January!

15 August 2010

Seeing probabilities

Filed under: aging, risks, Ultralase — David Wood @ 12:59 am

I thought of entitling this blogpost “Blinded by technology”.  Or, perhaps, “Almost blinded by technology”.  But that would have been unfair.

It’s now just over five weeks since I had my eyes lasered at the Ultralase clinic in Guildford, Surrey.  For more than 40 years, I had worn spectacles, to correct short sightedness.  My hope with the surgery was that I could dispense with spectacles and all the inconvenience that goes with them.

I had an idea what to expect.  Back in 2005, my wife had a similar operation, also from Ultralase, and has been very happy with the result.  I remember her being pleased with the outcome just a few moments after the operation, when, from the room next to the operating theatre, I could hear her excited voice on opening her eyes.  But my own experience turned out different.

One complicating factor is that I received a treatment called “monovision”, in which the two eyes are given treatments that optimise them for different viewing tasks.  My left eye was optimised for short-distance reading (such as computer screens, books, phone screens).  My right eye was optimised for medium-distance and long-distance.

The rationale for monovision is to address a decline in the power of eyes to change the distance where they’re focussing.  This is a condition called “Presbyopia” – sometimes known as “Aging eye”.  To quote from “The Eye Digest“:

A presbyopic eye loses its innate ability to clearly see all objects that are located at different distances. It can see some objects clearly but not all. In individuals who are less than 40 years of age, the eye can be thought of as an ‘auto-focus’  cameras. In an auto-focus camera, all one has to do to get sharp pictures is to point the camera in that direction, the auto-focus mechanism kicks in and you get sharp pictures. After age 40, the presbyopic eye can be thought of as a ‘fixed-focus’ camera. Fixed-focus cameras, the most basic of all cameras, have a nonadjustable lens. In general, a fixed-focus camera can take satisfactory photographs but it may produce a blurred picture if the subject is moving or is less than 6 feet (1.8 meters) away.

The presbyopic eye is also in a more or less ‘fixed-focus’ state. This means that a presbyopic eye will see clearly only at a particular distance. If you correct the presbyopic eye for distance with glasses or contact lenses, then it will clearly see all the distant objects and may read 20/20 on the distance vision eye chart, but there is no way it would be able to clearly read up-close with the distance vision correction. On the other hand if you correct the eye for reading up-close, then you will be able to read clearly, but there is no way you will be able to see distance objects clearly with the same correction. So reading vision is at the cost of distance vision and vice versa.

And as Wikipedia puts it:

Presbyopia is a health condition where the eye  exhibits a progressively diminished ability to focus on near objects with age. Presbyopia’s exact mechanisms are not known with certainty; the research evidence most strongly supports a loss of elasticity of the crystalline lens, although changes in the lens’s curvature from continual growth and loss of power of the ciliary muscles (the muscles that bend and straighten the lens) have also been postulated as its cause.

Similar to grey hair and wrinkles, presbyopia is a symptom caused by the natural course of aging. The first symptoms (described below) are usually first noticed between the ages of 40-50. The ability to focus on near objects declines throughout life, from an accommodation of about 20 dioptres (ability to focus at 50 mm away) in a child, to 10 dioptres at 25 (100 mm), and levels off at 0.5 to 1 dioptre at age 60 (ability to focus down to 1–2 meters only).

The word presbyopia comes from the Greek word presbys (πρέσβυς), meaning “old man” or “elder”, and the Neolatin suffix -opia, meaning “sightedness”.

I can’t deny it: by these measures, I’m aging!  I turned 51 in February.  And I have presbyopia to show for my age.   (Not to mention wrinkles…)

Monovision is one of the options offered to patients with presbyopia.  Not everyone copes well with monovision treatment.  Apparently, some people get headaches, from the two eyes having different preferred focal lengths.  For this reason, Ultralase gave me special spectacles to wear, as an experiment, for six weeks before the intended date of the operation.  These spectacles mimicked the intended outcome of the operation: left eye great for short-distance, right eye great for everything else.  Happily, I had no headache, and was pleased with how these spectacles worked for me.

So I approached the operation itself with high hopes.  And I can report that my left eye has turned out exactly as hoped.  Without glasses, my short-range sight is excellent.

But  my right eye has ended up in a less optimal state.  Subsequent tests by Ultralase, repeated on several occasions, confirm that my right eye is about -0.75 compared to what was intended.  When I look into the middle distance or long distance, without wearing glasses, I see things as much fuzzier than before (when I wore glasses).  To see things more clearly, I have to squint, or stand up and walk closer.  In practical terms, it causes inconvenience when I’m in meetings at work.  I can’t see what’s displayed on screens in conference rooms.  I sometime struggle to see the prices on the menus behind the counter at coffee shops.  And so on.

But to say that I have literally been “blinded by technology” (by the short blast of a laser) would be putting things much too strongly.  I can get by fine, most of the time.

Nor was I figuratively “blinded by technology” – in the sense of being naively over-optimistic about the outcome of a technical fix to address the symptoms of aging.  The Ultralase surgeon had carefully explained matters to me before the operation.  He even got me to fill in some blank paragraphs in a form, using my own words to confirm that I understood the risks associated with the surgery.  One blank paragraph was headed, “Four risks with the operation”.  Another was headed, “How will I cope, if the treatment doesn’t work as well as I hope”.  It was sobering.

I knew, before the operation, that there was a one-in-six chance that I would need a “top up” operation six months (or so) further down the line.  And that looks like what will happen to me.  The risks were significantly higher in my case than for most patients, because of the monovision treatment, and because my eyesight was starting from such a poor threshold (around -8.0).

Medical treatments frequently involve probabilities.  As with many other difficult decisions in life, it’s important to be able to understand probabilities, and to plan ahead for possible unwanted outcomes.

It’s still possible that my right eye will continue to improve by itself.  I read of cases where it took several months, after laser eye surgery, for an eye to completely settle down.  That’s why Ultralase require several months of stability in eyesight before doing any follow-up surgery.  My current guess is that I’ll be visiting the surgery again some time around January.  In the meantime, I’m putting up with some haziness in my middle-distance and long-distance vision.

Has this experience changed my attitude towards the wonder-powers of technology (for example, to address the problems of aging)?

Not really.  I already know, viscerally, from my many years in the hi-tech smartphone industry, that technical solutions frequently fail.  A team can have many thoughtful, experienced, super-smart people, developing new technology in a careful way, but still the results can go wrong.  You can take measures to try to reduce risks, but you can’t make all the risks go away.  And, in many cases,  you shouldn’t seek to make all the risks go away.  That way, you’d miss out many benefits from when risky projects turn out good.  But you should be aware of the risks beforehand, and try to quantify them.

For me, a one in six chance of needing the inconvenience of a second operation was a risk well worth taking.  And I still see things that way.

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