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20 January 2019

Rejuvenation. Now. Easier than we think?

Filed under: aging, books — Tags: , , , , — David Wood @ 11:25 pm

Chronic poor health is caused by the accumulation of biological damage in our body. Eventually the damage builds to such an extent that it kills us. Before reaching that nadir, the damage weakens us, slows us down, and makes us more vulnerable to all kinds of illness.

Accordingly, if we want more vitality, for longer, we need to find therapies that undo the biological damage in our bodies. And we need to apply these therapies on a regular basis.

These two paragraphs summarise a view about health that is becoming increasingly common these days. One of the champions of this “find therapies to fix the damage” school is the biomedical gerontologist Aubrey de Grey – chief science officer of the SENS Research Foundation. I write about this approach in, for example, Chapter 8, “Towards an abundance of health” of my own most recent book, “Sustainable Superabundance”.

The kinds of damage-repair therapies that transhumanist tend to talk about involve breakthrough new technologies – such as stem cell therapies, manipulation of genetics and epigenetics, nanotechnology, synthetic biology, and 3D bio-printing.

But what if there is already a very promising damage-repair treatment, whose power we frequently overlook?

Step forward Professor Matthew Walker of the Neuroscience department at UC Berkeley. Walker is also the founder and director of the Center for Human Sleep Science. Walker recently summarised the state-of-art understanding about sleep (and dreams), in his book “Why We Sleep: Unlocking the Power of Sleep and Dreams”. I started reading that book following a tip from London Futurists member Mark Goodman. That tip was one of the best I received in the whole of last year. Many thanks, Mark!

According to the wide research that Walker summarises in “Why We Sleep”, getting sufficient sound sleep on a regular basis is a great all-round boost to our health. Skimping on sleep – getting an average of only six hours a night, instead of the eight hours recommended – stores up lots of longer term damage. (For example: greater propensity to cancer, dementia, obesity, diabetes, heart condition…)

It’s not just a question of quantity of sleep. It’s a question of quality. Sometimes we have a sort of sleep – for example, when under the influence of alcohol – but that sleep doesn’t perform the rejuvenation miracles of good quality sleep.

It’s also a question of the different types of sleep – including the REM (Rapid Eye Movement) sleep that accompanies dreams, and the four different levels of NREM (not-REM) sleep (sleep when we’re not dreaming). The different kinds of sleep are associated with different kinds of healing.

To be clear, sleep isn’t just for healing. Many kinds of memory are improved by the right kinds of sleep. And sleep can be a great boost to creativity too.

The number of diseases linked to poor quality sleep is both staggering and frightening. People who scorn getting a good night’s sleep – people who boast that they can get by on, say, five hours a night on average – are deluding themselves. If you don’t believe this, look into the research that Walker assembles and discusses.

Of course, there are limits to the kinds of repair that sleeping and dreaming can perform. These fine therapies, by themselves, won’t boost anyone’s life expectancy from 75, say, to 125, or beyond. For that kind of change, we’ll need the initiatives being researched by SENS (and developed by an increasing number of commercial companies). But if you want to increase the chance of you (and your loved ones) living long enough to benefit from the eventual availability of SENS-type treatments, changing your sleep habits could make all the difference.

As well as increasing your life expectancy, these improved habits have the potential to improve your focus, your memory, your creativity, and the way you interact positively and supportively with others.

Changing your diet is another way in which you might increase your life expectancy. As an aside, the best single book I have come across on that topic is “The Longevity Code: The New Science of Aging” by Kris Verburgh. (Verburgh’s book actually has a lot more in it than just analysis of the relation between diet and healthy aging. It should definitely be on your bookshelf.)

But what’s striking is that, although the connection between diet and healthy aging has been widely discussed, the connection between sleep and healthy aging has been relatively ignored. Walker’s book should start to amend that unfortunate state of ignorance.

There are another three big reasons why transhumanists (and people who share the same broad interests) should read “Why we sleep”. First, the book offers (directly and indirectly) lots of insights about the nature of consciousness, as explored through the discussion of consciousness in different sleep states, including dreaming. I’m sure that there are insights ready to be sparked by some of these sections, for AI researchers struggling with particular conceptual problems.

Second, Walker discusses broader social factors connected with sleep (and why so many people sleep badly these days). The sheer scale of lives lost by drivers drifting into “micro sleeps” is astonishing: accidents caused by drowsiness exceed those caused by drugs and alcohol. The damage caused by sleeping pills is another eye-opener. It also turns out there’s a lot of inertia in society – society often resists changes that would be in its own best interest! The adverse practice of the medical industry pushing junior doctors to the limit, sleepwise, is just one case. But the book also has some great examples, in the closing chapters, about positive social change. One involves the time at which schools start. It turns out that moving the start time later by 30 minutes, or one hour, can have a big impact on successful learning, as well as on the prevalence of teenage depression (not to mention the likelihood of students having car accidents en route to school).

Third, Walker identifies both risks and opportunities from new technologies, as regards changing sleep quality. Small doses of electricity applied to the scalp can significantly improve sleep. Other mechanisms look like they can improve our dreams. In the not-so-distant future, the ways in which we sleep and dream might be quite different from today. Technology, if used wisely, could lead us to patterns of sleeping and dreaming in which rejuvenation happens more profoundly.

To conclude: I really liked the first few chapters of “Why We Sleep”, and wondered how the book could continue at the same level of engagement over the remainder of its 340 pages of content. But it did – it was thoroughly interesting all the way through!

Image source: Claudio_Scott on Pixabay.

19 September 2014

The new future of old age

In an enchanting four minute video, Korean artist Seok Jeong Hyeon, who is also known as Stonehouse, portrays the gradual aging of a baby girl. At first, the changes are slow, but they accumulate as years and then decades pass. The end result is an elderly woman, adorned with lines and wrinkles, who finally stops breathing.

The video is beautiful, and the woman maintains her own elegance to the end. As such, it presents a romantic view of aging. (And the video even hints at another romantic idea, namely reincarnation.)

In reality, as we age, we suffer from increasing numbers of aches and pains. We half-laugh when we say that we’re experiencing a “senior moment” of forgetfulness, but we notice our declining potency. Worse, every extra eight years that we live, past the age of around 35, we become twice as likely to die within the next year. In other words, our mortality rate increases exponentially. This was first observed in 1825 by British actuary and mathematician Benjamin Gompertz. Empirical data continues to support Gompertz, nearly two centuries later. For example, here’s a chart of the exponentially increasing death rate in the USA:

gompertz-mortality-curve

One of the factors underlying this upwards surge of mortality rate is the fact that, as we become older, we become increasingly vulnerable to various horrible diseases, such as cancer, heart disease, diabetes, Alzheimer’s, and lung disorders. Aging researcher Avi Roy of Oxford has collected information from the Office of National Statistics as follows:

Death rates from diseases

These five diseases aren’t random choices, by the way. They’re currently all high up in the list of the current largest causes of death.

The romantic notion of death is that we grow old gracefully, lose our powers almost imperceptibly, and die in our sleep, contented, surrounded by happy thoughts. In all too many cases, alas, death is preceded by viciously nasty diseases.

The Palo Alto prize

One of the deeply cherished visions of potential human progress has been the hope that, one day, we could reverse this state of affairs. Instead of the rate of mortality increasing with chronological age, it could remain constant. The terrible diseases listed, and others like them, which all currently increase their impact the older we get, could be conquered by the development of medicine – much the same as medicine has already made huge inroads against infectious diseases. The best solution would be, not a wide range of individual interventions each targeted at specific diseases, but an intervention that undoes the underlying damage of aging – the damage which accumulates throughout our body, and which makes it more likely that we fall prey to “diseases of old age”.

Until recently, that vision has lain well outside scientific orthodoxy. People have been loath to mention the idea, as it could spell the end of their academic careers.

However, that reticence seems to be changing. No less than eleven research teams from universities around the world have already publicly committed to entering for the recently announced “Palo Alto Longevity Prize”, which has a $1M prize fund. This video provides an introduction to the prize:

This video introduces key personnel from the different teams who are already engaged in developing solutions for contest:

.

The eleven teams and their leaders are listed in a recent TechCrunch article about the prize:

Doris Taylor, Ph.D.
Texas Heart Institute, Houston, TX
http://paloaltoprize.com/team/team-taylor-lab/ ‎
TEAM NAME: T.H.I. REGENERATIVE MEDICINE (approach: stem cells)

Dongsheng Cai, M.D., Ph.D.
Albert Einstein College of Medicine, New York, NY
http://paloaltoprize.com/team/cai-lab/
TEAM NAME: CAI LAB (approach: hypothalamic regulation)

Andreas Birkenfeld, M.D.
Charite University School of Medicine, Berlin, Germany
http://paloaltoprize.com/team/team-indy/
TEAM NAME: INDY (approach: gene modification)

Jin Hyung Lee, Ph.D.
Stanford University, Palo Alto, CA
http://paloaltoprize.com/team/team-lee-lab/
TEAM NAME: LEE LAB (approach: neuromodulation)

David Mendelowitz, Ph.D.
George Washington University, Washington, D.C.
http://paloaltoprize.com/team/team-mendelowitz-lab/
TEAM NAME: MENDELOWITZ LAB (approach: oxytocin)

Scott Wolf, M.D.
Mountain View, CA
http://paloaltoprize.com/team/volts-medical/
TEAM NAME: VOLTS MEDICAL (approach: inflammatory tissues)

Irving Zucker, Ph.D.
University of Nebraska Medical Center, Omaha, NE
http://paloaltoprize.com/team/team-zucker-lab/
TEAM NAME: ZUCKER LAB (approach: neuromodulation)

Brian Olshansky, M.D.
University of Iowa Medical Center, Iowa City, IA
http://paloaltoprize.com/team/team-olshansky-lab
TEAM NAME: IOWA PRO-AUTONOMIA (approach: not yet public)

William Sarill, M.A.
Arlington, MA
http://paloaltoprize.com/team/team-sarill-lab/
TEAM NAME: DECO (approach: pituitary hormones)

Steven Porges, Ph.D.
University of North Carolina, Chapel Hill, NC
http://paloaltoprize.com/team/team-porges-lab/
TEAM NAME: POLYVAGAL SCIENCE (approach: optimizing both the left & right vagal branches)

Shin-Ichiro Imai, M.D., Ph.D.
Washington University, St. Louis, MO
http://paloaltoprize.com/team/imai-lab/
TEAM NAME: IMAI LAB (approach: gene modification)

Approaching rejuvenation

AR Cover page v2In the light of all the fascinating developments around the field of increasing healthy longevity, I’ve decided that my next book will focus on that field.

The book is entitled “Approaching rejuvenation: Is science on the point of radically extending human longevity”. My intent is that the book will provide a bird’s eye report from the frontiers of the emerging field of rejuvenation biology:

  • The goals and motivations of key players in this field
  • The rapid progress that has been achieved in the last few years
  • The challenges that threaten to thwart further development
  • The critical questions that need to be faced.

The book will be based around material from interviews with more than a dozen researchers, engineers, entrepreneurs, and humanitarians, who are making it their life’s quest to enable human rejuvenation. I’ve already started doing these interviews.

I’m far from being an expert in any branch of biochemistry or medicine. However, I hope to bring five important angles to this writing task:

  1. My background in history and philosophy of science, wrestling with the question of how to distinguish science from pseudoscience, and the more general dilemma of how to decide whether lines of research are likely to turn out to be misguided dead-ends
  2. My professional career within the smartphone industry, where I saw a lot of similar aspirations (though on a much smaller scale) regarding the breakthroughs that fast-moving technology could enable
  3. My experience as a writer, in which I seek to explain complicated subjects in a relatively straightforward but engaging manner
  4. The six years in which I have had the privilege to organise meetups in London dedicated to futurist, singularitarian, and technoprogressive topics – meetings which have featured a wide variety of different attitudes and outlooks
  5. My aspiration as a humanitarian to probe for both the human upsides and the human downsides of changing technology – in order to set possible engineering breakthroughs (such as rejuvenation biotech) in a broader societal context.

If you have any suggestions or comments about this new book project, please don’t hesitate to get in touch.

The new future of old age

The London Futurists event next Saturday (27th September) addresses the same general theme. I close this blogpost with an excerpt from the description of the meetup. Please see the associated meetup page for more information about the speakers, for logistics details, and to register to attend. I hope to see some of you there!

Futurists, life extension advocates, transhumanists and others have been speaking for several decades already about the possibility, desirability, and broader consequences of significantly extending the human healthy lifespan. In this vision, the deteriorating effects of infirmity and old age could be radically postponed, and perhaps abolished altogether, via improvements in regenerative biotechnology.

Forget “70 is the new 50”. We might have the possibility of “150 is the new 50”. And alongside the existing booming cosmetics industry, with huge amounts spent to reduce the visible signs of aging, we might envision a booming rejuvenation industry, reversing the actual underlying biochemical damage that constitutes aging.

Recently, the pace of change in the field of healthy life extension seems to have increased: almost every day there are reports of possible breakthrough treatment methods, unexpected experimental results, new economic analyses of demographic changes, and innovative theoretical ideas. It’s hard to keep up with all these reports.

How can we evaluate this flurry of change?

Held in conjunction with the UN International Day of Older People (which occurs each year on 1st October), this event brings together a panel of expert speakers – William BainsMichael Price, Alex Zhavoronkov, and Sebastian Sethe – who will each give their assessment of “what’s new in the field of old age”:

  • What are some of the most significant research findings and other potential breakthroughs from the last five years?
  • What is the likelihood of significant practical change in healthy longevity within, say, the next 10-20 years?
  • What would be the economic, social, and psychological implications of such changes?
  • Are there any new grounds for scepticism or fear regarding these potential changes?
  • If individuals wish to help accelerate these changes, what should they do?
  • What are the major obstacles that could prevent real progress being made?

FB meeting image

 

 

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