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14 April 2025

Choose radical healthy longevity for all

Filed under: aging, Economics, healthcare, politics, The Abolition of Aging, vision — Tags: — David Wood @ 9:04 pm

What do you think about the possibility of radical healthy longevity?

That’s the idea that, thanks to ongoing scientific progress, new medical treatments may become available, relatively soon, that enable people to remain as vibrant and healthy in their 80s, 90s, and beyond, as they were in their 20s and 30s.

It’s the idea that it may soon become possible to systematically repair or replace, on a regular basis, the various types of damage that tend to accumulate in our bodies over the decades – damage such as plaques, tangles, chronic inflammation, DNA mutations and epimutations, dysfunctional mitochondria, weakened immune function, crosslinks between macromolecules, cells that increasingly neglect their original function, and so on. This damage would be removed before it gives rise to chronic diseases.

It’s the idea, in other words, that aging as we know it – experienced as an inevitable deterioration – could be overcome by scientific innovations, well within the lifetimes of many people who are already adults.

It’s a divisive idea. Some people love it but others seem to hate it. Some people see it as liberating – as enabling lives of abundance. Others see it as being inherently unnatural, unethical, or unjust.

In more detail, I’ve noticed four widespread attitudes regarding this idea:

  1. It’s an unscientific fantasy. Radical healthy longevity won’t be possible any time soon.
  2. It will be the ultimate in inequality. Radical healthy longevity will be available only to a small minority of people; everyone else will receive much poorer medical treatment.
  3. It’s guaranteed that it will be a profound universal benefit. Everyone who is fortunate enough to live long enough to be alive at a threshold point in the future will benefit (if they wish) from low-cost high-quality radical healthy longevity.
  4. It’s an outcome that needs to be fought for. There’s nothing inevitable about the timing, the cost, the quality, or the availability of radical healthy longevity.

Before reading further, you might like to consider which of these four attitudes best describes you. Are you dismissive, fearful, unreservedly optimistic, or resolved to be proactive?

Who benefits?

To briefly address people inclined to dismiss the idea of radical healthy longevity: I’ve written at length on many occasions about why this idea has strong scientific backing. For example, see my article from May last year, “LEV: Rational Optimism and Breakthrough Initiatives”. Or consider my more recent Mindplex article “Ten ways to help accelerate the end of aging”. I won’t repeat these arguments in this article.

What is on my mind, however, is the question of who will benefit from radical healthy longevity. That’s a question that keeps on being raised.

For example, this is an extract from one comment posted under my Mindplex article:

If you want me to be an anti-aging influencer, the first thing I am going to ask you is “how is this going to be affordable?” How can you guarantee that I not serving only the agenda of the rich and the elite?

And here are some extracts from another comment:

Longevity is ruined by rich people and some elite politicians… Funding for anti-aging research tends to be controlled by those with deep pockets. In reality, the rich and powerful usually set the agenda, and I worry that any breakthroughs will only benefit an elite few rather than the general public… I’ve seen this play out in other areas of medicine and tech (big pharma and cancer are the best examples), where groundbreaking ideas are co-opted to serve market interests, leaving everyday people out in the cold.

The possible responses to these concerns mirror the four attitudes I’ve already listed:

  1. This discussion is pretty pointless, since relevant treatments won’t exist any time soon. If anything, this whole conversation is a regrettable distraction from spreading real-world health solutions more widely
  2. The concerns are perceptive, since there’s a long history of two-tier health solutions, compounding what is already a growing “longevity gap”
  3. The concerns are misplaced, since the costs of profound new health solutions will inevitably fall
  4. The concerns are a wake-up call, and should motivate all of us to ensure new treatments become widely available as soon as possible.

To restate the fourth response (which is the one I personally favour): we need to choose radical healthy longevity for all. We need to fight for it. We need to take actions to move away from the scenario “the ultimate in inequality” and toward the scenario “a guaranteed profound universal benefit”. That’s because both of these scenarios are credible possible futures. Each extrapolates from trends already in motion.

Extrapolating what we can already see

The scenario “a guaranteed profound universal benefit” takes inspiration from the observation that the cost of products and services often drops dramatically over time. That was the case with computers, smartphones, flat screen TVs, and many other items of consumer electronics. Even when prices remain high, lots of new features become included in the product – as in the case of motor cars. These improvements arise from economies of scale, from competition between different suppliers, and from the creative innovation arising.

But there’s no inevitability here. Monopolies or industry cartels can keep prices high. Strangleholds over IP (intellectual property) can hinder the kind of competition that would otherwise improve consumer experience. Consider the sky-high pricing of many medical procedures in various parts of the world, such as the United States. For example, research by Stacie Dusetzina of the University of North Carolina at Chapel Hill highlights how the costs in the United States of treatment of cancer by the newest pills rose sixfold over a recent 14-year period. That’s after taking account of inflation. And the inflation-adjusted cost of a millilitre of insulin, used in the treatment of diabetes, increased threefold over a recent 11-year period. Many other examples could be listed. In various ways, these examples all fit the well-known pattern that free markets can experience market failures.

A counter-argument is that, provided the benefits of new health treatments are large enough, it will become politically necessary for the state to intervene to correct any such market failures. Early application of the kinds of damage-repair and damage-removal treatments mentioned earlier, will result in a huge “longevity dividend“. The result will be to reduce the costs that would otherwise be incurred as age-related diseases take their toll (often with more than one co-morbidity complicating treatment options). According to the longevity dividend, it’s economically desirable to spend a smaller amount of money, earlier, as a preventive measure, than to have to pay much more money later, trying to alleviate widespread symptoms. No sensible political party could ignore such an imperative. They would surely be voted out of office. Right?

Uncertain politics

Alas, we need to reckon not only with occasional market failures but also with occasional political failures. There’s no guarantee that political leaders will take actions that benefit the country as a whole. They can be driven by quite different motivations.

Indeed, groups can seize power in countries and then hold onto it, whilst giving only lip service to the needs of the voters who originally elected them. Leaders of these groups may assert, beforehand, that voters will prosper in the wake of the revolution that they will bring. But by the way, for the success of this transformation, voters will need to agree that the revolutionary leaders can ride roughshod over normal democratic norms. These leaders will be above the law – 21st century absolute monarchs, in effect. But then, guess what, inflation remains high, unemployment surges, the environment is despoiled, freedoms are suspended, and protestors who complain about the turn of events are rounded up and imprisoned. Worse, due to the resulting crisis, future elections may be cancelled. As for universal access to radical healthy longevity, forget it! The voters who put the revolutionaries in power are now dispensable.

That’s only one way in which the scenario “the ultimate in inequality” could unfold. Less extreme versions are possible too.

It’s a future that we should all seek to prevent.

Choosing to be proactive

Is the answer, therefore, to urge a cessation of research into treatments that could bring about radical healthy longevity? Is the answer to allow our fears of inequality to block the potential for dramatic health improvements?

I disagree. Strongly. On the contrary, the answer is to advance several initiatives in parallel:

  • To increase the amount of public funding that supports research into such treatments
  • To avoid political conditions in which market failures grow more likely and more severe
  • To avoid social conditions in which political failures grow more likely and more treacherous

All three of these tasks are challenging. But all three of them make good sense. They’re all needed. Omit any one of these tasks and it becomes more probable that the future will turn out badly.

As it happens, all three tasks are choices to be proactive – choices to prevent problems early, rather than experiencing much greater pain if the problems are allowed to grow:

  • Problems from an accumulation of biological damage inside and between our cells, causing an escalation of ill-health
  • Problems from an accumulation of political damage, causing an escalation of economic dysfunction
  • Problems from an accumulation of societal damage, causing an escalation of political dysfunction

So, again I say, it is imperative that, rather than passively observing developments from the sidelines, we actively choose radical healthy longevity. That’s biological health, political health, and societal health.

Whether through advocacy, funding, research, or policy engagement, everyone has a role to play in shaping a profoundly positive future. By our actions, coordinated wisely, we can make a real difference to how quickly people around the world can be freed from the scourge of the downward spiral of aging-related ill-health, and can enjoy all-round flourishing as never before.

2 May 2024

LEV: Rational Optimism and Breakthrough Initiatives

Filed under: aging, rejuveneering, The Abolition of Aging — Tags: , , , — David Wood @ 8:51 am

How likely is it that longevity escape velocity (LEV) will be achieved by, say, 2040?

In other words, how likely is it that, by 2040, biomedical interventions will be widely available that result in each adult becoming (if they wish) biologically younger – becoming systematically healthier and more resilient?

In that scenario, to give one illustration, adults who are aged 65 in 2050 will generally be healthier than they were at the age of 50 some 15 years earlier. They’ll be mentally sharper, with stronger muscles, a better immune system, cleaner arteries, and so on. That’s instead of them following the downward health spiral which has accompanied human existence throughout all of history so far – a spiral in which each additional year of life from middle age onward brings a decline in vitality and robustness, and an increase in the probability of death.

Members of the extended longevity community express a variety of degrees of optimism or pessimism on such questions. The pessimists highlight what they see as a lack of significant progress over recent decades: not a single person has reached the age of 120 this century. They also lament the apparent unfathomable complexity of the biological metabolism, and differences of opinion over theories of what actually causes aging. They may conclude that the chance of reaching LEV by 2040 is less than one percent.

In contrast to that pessimism, I believe there are strong grounds for optimism. That’s the subject of this essay.

To be clear, there’s no inevitabilism to my optimism. I offer a probability for success, rather than any certainty. Whether humanity makes it to LEV by 2040 still remains to be seen.

Theories of aging

It’s true that aging is complicated. However, we don’t need to understand all aspects of aging in order to reverse it. Nor do we need to map out a comprehensive diagram of all the relationships of cause and effect at the biochemical level. Nor to pinpoint all the interactions of every gene in every cell of the body. Nor to debate whether aging happens because of evolution or despite evolution. Nor whether aging is best understood from a “reductionist” perspective or a “holistic” perspective.

Instead, to my mind, we already understand enough. There are plenty of details still to be filled in, but we already understand the basic framework that can lead to the comprehensive reversal of aging.

I’m referring to the damage repair approach to ending aging. This approach views aging as the accumulation of damage at the cellular and biomolecular levels throughout our bodies, with that damage in turn reducing the vitality of bodily subsystems. Moreover, this approach maintains that our biological vitality can be restored by repeatedly intervening to remove or repair that damage before it reaches a critical level.

What needs to be researched, therefore, is the set of interventions that can be developed and applied to remove or repair biological damage, without having adverse side-effects on overall metabolism.

These interventions need to be understood at an engineering level rather than at a detailed scientific level. We need to ascertain that such-and-such interventions result in given observable reductions in cellular or biomolecular damage. The way in which damage accumulates before being removed or repaired is of secondary concern.

This approach involves categorizing different types of damage, where each type of damage is associated with one or more potential mechanisms that could repair or remove it. Examples include:

  • A decline in the number or health of stem cells available – which could be addressed by the introduction of new stem cells
  • An accumulation of cells that are in a senescent state – which could be addressed by bolstering the innate biological mechanisms that normally break down these senescent cells
  • Damage to the long-lived proteins in the extra-cellular matrix that normally supports cells, with results such as the stiffening of arteries – which could be addressed by a variety of mechanisms including breaking crosslinks between adjacent proteins.

In this understanding, what needs to be done, to accelerate the advent of LEV, is to:

  • Identify and research mechanisms that have the potential to remove or repair aspects of the damage
  • Determine how these mechanisms might be applied in practice
  • Consider and monitor for potential side-effects of these mechanisms, and, as required, design modifications or alternatives to them
  • Consider and monitor for potential interactions between various such mechanisms.

This program was first suggested over twenty years ago. It was the subject of a major book published in 2007, Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime, and it has been explored in a series of academic conferences held at various times from 2003 onward in Queens’ College Cambridge, San Francisco, Berlin, and Dublin. (Since you ask, the next one in that series is taking place in Dublin from 13-16 June.)

My own optimism that LEV might be achieved by 2040 is based on my assessment of the viability of this damage repair approach. In turn, that’s because I see:

  • A wide set of potential damage repair interventions that deserve further study
  • Early encouraging signs that damage repair can extend healthy lifespans in various species
  • A general pattern that slow progress in a field can transition into a new phase with much faster progress
  • Ways in which “breakthrough initiatives” can trigger such a phase transition for the project to achieve LEV.

I’ll now turn to each of these four points in sequence.

Damage repair mechanisms – plenty to explore

There are five basic sources of ideas for mechanisms to repair or remove damage at the cellular and biomolecular levels throughout the body:

  1. Identifying and improving the repair mechanisms that already work within the human body when we are younger – before these mechanisms lose their effectiveness
  2. Learning from the special self-repairing features of the small proportion of humans who are “superagers” in the sense that they reach the age of 95 without having suffered any of the usual age-related diseases such as heart disease, cancer, dementia, or stroke
  3. Learning from the fascinating self-repairing features of numerous species which avoid various age-related diseases, and which can retain their vitality for decades longer than other species with whom they share many other characteristics
  4. Learning from other regenerative features that various species possess, such as the regrowth of damaged limbs or organs, as well as the birth of a baby whose cells are aged zero from parents who can be many decades older
  5. New interventions that don’t exist anywhere in nature, but which can be introduced as a result of scientific analysis and engineering innovation (relatively simple examples are blood transfusions, and stents that can repair a narrowed or blocked blood vessel; more complicated examples involve nanobots and 3D printing).

Progress so far

Here are some pointers to descriptions of various results obtained so far from investigations of possible damage repair interventions – disappointments as well as successes:

Some conclusions from this data are uncontentious:

  • None of these treatments, so far, have resulted in animals passing the LEV threshold
  • The extension of healthy lifespan achieved in these trials is generally less than 50%, and is usually significantly less than that
  • Results obtained in experiments with shorter-lived animals, such as mice and rats, often do not translate into similar results with humans (or have not done so yet).

These conclusions would appear to bolster the case for pessimism mentioned earlier. However, they are by no means the entire story:

  • The various trials indicate that at least some rejuvenation can be engineered, and that there are multiple ways of doing so
  • Trials of combinations of different rejuvenation treatments (which might be expected to have more substantial results) are still at an early stage
  • Nothing like a proof of impossibility has been found, or even seriously suggested
  • The total amount of resources dedicated to this field is far below that in many other fields of scientific research; the field might, plausibly, be expected to make faster improvements if it gains more support.

Key to faster progress will be the removal of roadblocks. That’s the subject of the remainder of this essay.

The possibility of a phase change

Sometimes a field of technology or other endeavour remains relatively stagnant for decades, apparently making little progress, before bursting forward in a major new spurt of progress. Factors that can cause such a tipping point to such a phase change include:

  • The availability of re-usable tools (such as improved microscopes, molecular assembly techniques, diagnostic tests, or reliable biomarkers of aging)
  • The availability of important new sets of data (such as population-scale genomic analyses)
  • The maturity of complementary technologies (such as a network of electrical recharging stations, to allow the wide adoption of electric vehicles; or a network of wireless towers, to allow the wide adoption of wireless phones)
  • Vindication of particular theoretical ideas (such as the paramount importance of mechanisms of balance, in the earliest powered airplanes; or the germ theory for the transmission of infectious diseases)
  • Results that demonstrate possibilities which previously seemed beyond feasibility (such as the first time someone ran a mile in under four minutes)
  • Fear regarding a new competitive threat (such as the USSR launching Sputnik, which led to wide changes in the application of public funding in the United States)
  • Fear regarding an impending disaster (such as the spread of Covid-19, which accelerated development of vaccines for coronaviruses)
  • The availability of significant financial prizes (such as those provided by the XPrize)
  • A change in the attitude of researchers about the attractiveness of working in the field
  • A change in the public narrative regarding the importance of the field
  • The different groups who are all trying to find solutions to problems in the field finding and committing to a productive new method of collaboration on what turns out to be core issues.

When such factors apply – especially in combination – it can transform the pace of a change in a field from “linear” or “incremental” to “exponential” or “disruptive”, meaning that progress which previously was forecast as requiring (say) 100 years of research might actually happen within (say) 15 years.

That’s a general pattern. Now let’s consider how it can apply to accelerating progress toward LEV.

The existing roadblocks

Based on my observations of the longevity community stretching back nearly twenty years, here are my own assessment of the roadblocks which are presently hindering progress toward LEV:

  1. Lack of funding for some of the experiments that would produce important new data, since commercial interests such as VCs see little prospect of them earning a financial return from supplying that funding.
  2. Some people who are in a position to supply funding to support important experiments choose not to do so, because they are dominated by a mindset (sometimes called “longevity myths” or the “pro-aging trance”) that it’s wrong to support significantly longer lifespans.
  3. More broadly: society as a whole assigns insufficient priority to the comprehensive prevention and reversal of age-related diseases.
  4. Some potential supporters are deterred by what they perceive as irresponsible or untrustworthy aspects of the longevity field (snake-oil solutions, uncritical claims, tedious infighting).
  5. There is disagreement or confusion about which experiments are most important; as a result, available funds are being misdirected into, for example, less useful “lifestyle research”.
  6. Related: there is no agreed list of which experiments (or other research) should be conducted next, once additional funds become available.
  7. In the absence of biometrics that are accepted as being good measurements of overall biological aging (as opposed to measuring only an aspect of biological aging), it’s hard to know whether treatments increase the life expectancy of any long-lived animal.
  8. It’s likely that pools of data already in existence contain important insights related to aging and its possible alleviation – namely biological and other health data about individuals as they age and pass through different experiences and treatments. However, much of this data is kept in proprietary or private databases and isn’t made available for scrutiny by other researchers. Especially with the greater power nowadays of data analysis tools such as deep learning, the potential for open analysis isn’t being achieved. (This is another example where commercial or personal concerns are preventing the development of public goods from which everyone would benefit.)

Given this analysis, let’s look at four initiatives that could coalesce to cause the kind of phase transition discussed above.

The breakthrough initiatives

From one perspective, the breakthrough initiatives involve biomedical reengineering: projects such as the RMR (Robust Mouse Rejuvenation) study of combination interventions, designed and managed by the LEV Foundation. These are projects which have the potential to make the whole world wake up and pay attention.

But from another perspective, what most needs to change is the availability and application of sufficient funding to allow many such biomedical engineering projects to proceed in parallel. This can be termed the rejuvenation financial reengineering initiative – the initiative to direct more of the world’s vast financial resources toward these projects.

Taking one step further back, the financial reengineering will be facilitated by perhaps the most important initiative of all – namely narrative reengineering, altering the kinds of stories people in society tell themselves about the desirability of the comprehensive prevention and reversal of age-related diseases. Whereas today many people have an underlying insight that aging and death are deeply regrettable, they manage to persuade themselves (and each other) that there’s nothing that can be done about these trends, so that the appropriate response is to “accept what cannot be changed”. That is, they lack “the courage to change what can be changed”, in turn (to complete the citation of the so-called “serenity prayer” of Reinhold Niebuhr) because they lack the wisdom (or awareness) that such change is possible.

In parallel, important elements of community reengineering are required:

  • To clarify which experiments and research have the biggest potential for dramatic results
  • To avoid behaviours or statements which alienate or deter important potential supporters
  • To reduce amounts of wasteful duplication and “noise”
  • To develop and publicise meaningful quantitative metrics of progress toward LEV
  • To share more openly both the successes and the failures of experiments conducted, to allow more effective collaborative learning.

The breakthrough narratives

Some observers are pessimistic about any changes any time soon in the public narrative about the desirability of reaching LEV. These observers say they have been awaiting such a change for years or even decades, without it happening.

Part of the answer is that experimental results will make people pay attention. When middle-aged mice have their remaining life expectancy doubled – and then when similar treatments become available for middle-aged pet dogs – it is going to cause a large number of “road to Damascus” conversion experiences. People will set aside their former proclaimed “acceptance” of aging and death, and will instead start to clamor for rejuvenation treatments to be made available for humans too, as soon as possible.

But another part of the answer is to develop new themes within the public conversation related to aging and death. If these new themes have sufficient innate interest, they may develop a momentum of their own.

Here are some of the potential “breakthrough narratives” that I have in mind:

  1. Building on top of the latest “longevity dividend” and “evergreen society” arguments in the new book by the economist Andrew Scott, The Longevity Imperative: How to Build a Healthier and More Productive Society to Support Our Longer Lives, to highlight the broader economic and social benefits of biorejuvenation treatments
  2. The fascinating learning that can be obtained from looking more closely at the damage repair mechanisms already utilized by some “superaging” animal species; more and more of these mechanisms are being discovered and explored, and deserve greater publicity.
  3. Additional learning that can be obtained from further study into human superagers. Note that, for evolutionary reasons, it is likely that different superaging families around the world employ different biological damage repair mechanisms.
  4. The RMR narrative that the particularly useful data to collect is that from the combination of multiple treatments administered in mid-life; as this data accumulates, it is likely to give rise to lots of new theories about interactions between these treatments.
  5. The attractiveness of extending the RMR projects (for the robust rejuvenation of middle-aged mice) to similar investigations that might be called RDR (focused on dogs) and RSR (focused on simians, that is, monkeys and apes).
  6. The ups and downs of the various teams that are entering the XPrize Healthspan – a contest that can be seen as promoting an “RHR” extension (the ‘H’ for “human) to the RMR / RDR / RSR progression mentioned above
  7. A new analysis to supersede the existing “hallmarks of aging” diagrams, with a richer model of the interactions between different types of aging damage and the different possible damage repair mechanisms.
  8. Exploration of some “left field” rejuvenation interventions, such as those of Jean Hébert about growing and using replacement organs (including gradual replacement of parts of our brains), and those of Michael Levin about the ways in which the electrome can trigger biorejuvenation.
  9. The new possibilities that are continuing to emerge that take advantage of CRISPR-style genetic reprogramming and the reprogramming of epigenetics by Yamanaka factors or other means.
  10. More powerful AI platforms can enable faster advances in fields of science than were previously expected; examples include AlphaFold by DeepMind and the so-called menagerie of AI models utilised by Insilico Medicine
  11. Further championing of the ideas of anti-death philosopher Ingemar Patrick Linden from his book The Case Against Death.
  12. Engaging new video versions of some of the above narratives, in the manner of the CGP Grey video of Nick Bostrom’s allegory “Fable of the Dragon Tyrant” and those in the “Aging” YouTube playlist of Andrew Steele.

A probability, not a certainty

As I said earlier, there’s nothing inevitable about the longevity community experiencing the kind of tipping point and phase transition that I have described above.

Instead, I estimate the probability of humanity reaching LEV by 2040 to be less than 50%, although more than 25%. That’s because there are plenty of things that can go wrong along the way:

  • Distractions and loss of focus
  • Too much infighting and lack of constructive collaboration
  • A decline in the understanding and use of scientific methods
  • The field becomes dominated by pseudoscience, uncritical hero-worship, snake-oil, or wishful thinking
  • A growth of societal irrationality and preference for conspiracy thinking
  • An adverse change in the global political and geopolitical environment
  • The triggering of one or more of what I have called “Landmines”.

Which set of forces will prevail – the ones highlighted by the optimists, or those highlighted by the pessimists?

Frankly, it’s still too early to tell. But each of us can and should help to influence the outcome, by finding the roles where we can make the biggest positive impact.

29 December 2020

The best book on the science of aging in the last ten years

Filed under: aging, books, rejuveneering, science, The Abolition of Aging — Tags: , — David Wood @ 10:44 am

Science points to many possibilities for aging to be reversed. Within a few decades, medical therapies based on these possibilities could become widespread and affordable, allowing all of us, if we wish, to remain in a youthful state for much longer than is currently the norm – perhaps even indefinitely. Instead of healthcare systems continuing to consume huge financial resources in order to treat people with the extended chronic diseases that become increasingly common as patients’ bodies age, much smaller expenditure would keep all of us much healthier for the vast majority of the time.

Nevertheless, far too many people fail to take these possibilities seriously. They believe that aging is basically inevitable, and that people who say otherwise are deluded and/or irresponsible.

Public opinion matters. Investments made by governments and by businesses alike are heavily influenced by perceived public reaction. Without active public support for smart investments in support of the science and medicine that could systematically reverse aging, that outcome will be pushed backwards in time – perhaps even indefinitely.

What can change this public opinion? An important part of the answer is to take the time to explain the science of aging in an accessible, engaging way – including the many recent experimental breakthroughs that, collectively, show such promise.

That’s exactly what Dr Andrew Steele accomplishes in his excellent book Ageless: The new science of getting older without getting old.

The audio version of this book became available on Christmas Eve, narrated by Andrew himself. It has been a delight to listen to it over the intervening days.

Over the last few years, I’ve learned a great deal from a number of books that address the science of aging, and I’ve been happy to recommend these books to wider audiences. These include:

But I hope that these esteemed authors won’t mind if I nominate Andrew Steele’s book as a better starting point into the whole subject. Here’s what’s special about it:

  • It provides a systematic treatment of the science, showing clear relationships between the many different angles to what is undeniably a complex subject
  • The way it explains the science seems just right for the general reader with a good basic education – neither over-simplified or over-dense
  • There’s good material all the way through the book, to keep readers turning the pages
  • The author is clearly passionate about his research, seeing it as important, but he avoids any in-your-face evangelism
  • The book avoids excessive claims or hyperbole: the claims it makes are, in my view, always well based
  • Where research results have been disappointing, there’s no attempt to hide these or gloss over them
  • The book includes many interesting anecdotes, but the point of these stories is always the science, rather than the personalities or psychologies of the researchers involved, or clashing business interests, or whatever
  • The information it contains is right up to date, as of late 2020.

Compared to other research, Ageless provides a slightly different decomposition of what is known as the hallmarks of aging, offering ten in total:

  1. DNA damage and mutations
  2. Trimmed telomeres
  3. Protein problems: autophagy, amyloids and adducts
  4. Epigenetic alterations
  5. Accumulation of senescent cells
  6. Malfunctioning mitochondria
  7. Signal failure
  8. Changes in the microbiome
  9. Cellular exhaustion
  10. Malfunction of the immune system

As the book points out, there are three criteria for something to be a useful “hallmark of aging”:

  1. It needs to increase with age
  2. Accelerating a hallmark’s progress should accelerate aging
  3. Reducing the hallmark should decrease aging

The core of the book is a fascinating survey of interventions that could reduce each of these hallmarks and thereby decrease aging – that is, decrease the probability of dying in the next year. These interventions are grouped into four categories:

  1. Remove
  2. Replace
  3. Repair
  4. Reprogram

Each category of intervention is in turn split into several subgroups. Yes, the treatment of aging is likely to be complicated. However, there are plenty of examples in which single interventions turned out to have multiple positive effects on different hallmarks of aging.

There are a couple of points where some readers might quibble with the content, for example regarding dietary supplements, or whether the concept of group selection can ever be useful within evolutionary theory.

However, my own presentations on the subject of the abolition of aging will almost certainly evolve in the light of the framework and examples in Ageless. I’m much the wiser from reading it.

Here’s my advice to anyone who, like me, believes the subject of reversing aging is important, and who wishes to accelerate progress in this field:

  • Read Ageless with some care, all the way through
  • Digest its contents and explore the implications, for example via discussion in online groups
  • Recommend others to read it too.

Ideally, a sizeable proportion of the book’s readers will alter their own research or other activity, in order to assist the projects covered in Ageless.

Finally, a brief comparison between Ageless and the remarkable grandfather book of this whole field: Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime, authored by Aubrey de Grey and Michael Rae. Ending Aging was published in 2007 and remains highly relevant, even though numerous experimental findings and new ideas have emerged since its publication. There’s a deep overlap in the basic approach advocated in the two books. Both books are written by polymaths who are evidently very bright – people who, incidentally, did their first research in fields outside biology, and who brought valuable external perspectives to the field.

So I see Ageless as a worthy successor to Ending Aging. Indeed, it’s probably a better starting point for people less familiar with this field, in view of its coverage of important developments since 2007, and some readers may find Andrew’s writing style more accessible.

24 April 2019

Supporting the SomosMiel revolution: time to act

Filed under: politics, rejuveneering, The Abolition of Aging — Tags: , , , , , — David Wood @ 3:46 am

The most important changes often arise from the bold actions of outsiders.

Those of us who desire positive humanitarian change need to be flexible enough to recognise which outsiders can be the best vehicles for the transformations we want to see in society.

And we need to be ready to get behind these opportunities when they arise.

Consider the key example of the transformation of healthcare, towards a new focus on the reversal of aging as providing the best route to better health for everyone.

For those of us who hold that vision of the forthcoming “abolition of aging”, what are the most practical steps to make that vision a reality?

Here’s my answer. It’s time to get behind “Somos Miel”.

Futuristicamente

Miel is a recently formed political party, which is taking part in Spain in the elections on the 26th of May to the European Parliament.

The word “miel” has two meanings. First, it’s the Spanish for “honey”. Somos Miel means “We are honey”. The association of honey with improved health exists in many cultures around the world.

Second, MIEL is the abbreviation for “Movimiento Independiente Euro Latino”. Translating from Spanish to English gives: “The Independent Latin Euro Movement”.

Heading the party’s list of candidates is José Cordeiro, described as follows in the introduction of his Wikipedia article:

José Luis Cordeiro is an engineer, economist, futurist, and transhumanist, who has worked on different areas including economic development, international relations, Latin America, the European Union, monetary policy, comparison of constitutions, energy trends, cryonics, and longevity. Books he has authored include The Great Taboo, Constitutions Around the World: A Comparative View from Latin America, and (in Spanish) El Desafio Latinoamericano (“The Latin American challenge”) and La Muerte de la Muerte (“The death of death”).

Cordeiro was born in Caracas, Venezuela from Spanish parents who emigrated from Madrid during the Franco dictatorship…

He’s evidently a man of many talents. He’s by no means a European political insider, infused by the old ways of doing politics. Instead, he brings with him a welcome spread of bold outsider perspectives.

When asked if he is from “the right” or “the left”, his answer, instead, is that he is from “the future”. Indeed, he often appends the greeting “futuristicamente” after his name, meaning “Yours futuristically”.

José is also known as a vocal advocate for “revolution” – a revolution in the potential of humanity. He has the courage to advocate ideas that are presently unpopular – ideas that he believes will soon grow in public understanding and public support.

Working together

I first met José at the TransVision 2006 conference in Helsinki, Finland. I remember how he spoke with great passion about the positive possibilities of technology in the next stage in the evolution of life on the earth. As the abstract from that long-ago talk proclaims:

Since the Big Bang, the universe has been in constant evolution and continuous transformation. First there were physical and chemical processes, then biological evolution, and finally now technological evolution. As we begin to ride the wave into human redesign, the destination is still largely unknown but the opportunities are almost limitless.

Biological evolution continues but it is just too slow to achieve the goals now possible thanks to technological evolution. Natural selection with trial and error can now be substituted by technical selection with engineering design. Humanity’s monopoly as the only advanced sentient life form on the planet will soon come to an end, supplemented by a number of posthuman incarnations. Moreover, how we re-engineer ourselves could fundamentally change the ways in which our society functions, and raise crucial questions about our identities and moral status as human beings.

Since that first meeting, the two of us have collaborated on many projects. For example, we both sit on the board of directors of Humanity+. José has spoken on a number of occasions at the London Futurists events I organise – such as TransVision 2019 which will take place in London on 6-7 July. And we are named as co-authors of the Spanish language book La Muerte de la Muerte which has attained wide press coverage throughout Spain.

Another thing we have in common is that we are both impatient for change. We’re not content to sit back and watch impersonal forces operate in society at their own pace and following their own inner direction. We believe in doing more than cheering from the sidelines. We both believe that the actions of individuals, wisely targeted, can have a huge impact on human affairs. We both believe that inspired political action, at the right time, can unleash vast public resources in support of important transformational projects.

We also recognise that delays have major consequences. Each single day that passes without the widespread availability of reliable treatments for biological aging, upwards of 100,000 people die as a result of aging-related diseases. That’s 100,000 unnecessary human deaths, every single day – preceded in almost every case by extended suffering and heartache.

Moving faster

On a positive note, there is considerable good news to report, regarding progress with regenerative medicine and rejuvenation biotechnology. The Undoing Aging conference in Berlin last month contained an encouraging set of reports from a host of world-leading scientists working in this field. Keep an eye on the Undoing Aging channel in YouTube for videos from that event. For a review of the human implications of these scientific breakthroughs, the forthcoming RAADfest in Las Vegas in October will be well worth attending – to hear about “the most powerful information and inspiration for staying alive”.

But the opportunity exists for progress to go much faster, if more elements of society decide to put their weight behind this project.

That’s where Miel comes in. José is a well-known figure in Spain, due to his many media appearances there. Current indications are that he stands a fighting chance of being elected to the European Parliament. If elected, he’ll be a tireless public advocate for the cause of rejuvenation healthcare. He’ll promote studies of the economic implications of different scenarios for the treatment of aging. He’ll also champion the creation of a European Agency for Anti-Aging, to boost research on how addressing aging can have multiple positive benefits for the treatments of individual aging-related diseases, such as dementia, cancer, and heart failure.

You’ll find a number of articles on the Miel blog about these aspects of Miel policy. For example, see “Within 25 years, dying will be optional” and “I’m not afraid of artificial intelligence, I’m afraid of human stupidity”.

You’ll also observe from its website how Miel is, wisely, giving voice in Spain to a community that perceives itself to be under-represented, namely the Latin Americans – people like José himself, who was born in Venezuela. Those of us who aren’t Latin Americans should appreciate the potential for positive change that this political grouping can bring.

Time for action

Despite the groundswell of popular support that Miel is receiving, it’s still in the balance whether the party will indeed receive enough votes throughout Spain to gain at least one member in the European Parliament.

I’m told that what will make a big difference is an old-fashioned word: money.

If it receives more donations, Miel will be able to place more advertisements in social media (Facebook, YouTube, Instagram, etc). With its messages in front of more eyeballs, the chance increases of popular support at the ballot box.

In a better world, money would have a lower influence over politics. But whilst we should all aspire to move politics into that better state, we need to recognise the present reality. In that reality, donations have a big role to play.

To support Miel, visit the party’s donation page. Donations are accepted via credit cards, debit cards, or PayPal.

But please don’t delay. The elections are in just one month’s time. The time for action is now.

3 May 2018

Recommended: The Longevity Code

Filed under: books, converged medicine, rejuveneering, The Abolition of Aging — Tags: , , — David Wood @ 12:18 pm

If you’re interested in the latest advice on how to extend your healthspan, you should read The Longevity Code by Kris Verburgh.

The full title of the book is “The Longevity Code: Secrets to Living Well for Longer, from the Front Lines of Science”.

The book has the following description (on Goodreads):

Medical doctor and researcher Kris Verburgh is fast emerging as one of the world’s leading research authorities on the science of aging. The Longevity Code is Dr. Verburgh’s authoritative guide on why and how we age — and on the four most crucial areas we have control over, to slow down, and even reverse, the aging process.

We learn why some animal species age hardly at all while others age and die very quickly, and about the mechanisms at work that slowly but definitely cause our bodies to age, making us susceptible to heart attack, stroke, cancer, pneumonia and/or dementia.

Dr. Verburgh devotes the last third of The Longevity Code to what we can do to slow down the process of aging. He concludes by introducing and assessing the wide range of cutting-edge developments in anti-aging technology, the stuff once only of science fiction: new types of vaccines, and the use of mitochondrial DNA, CRISPR proteins, stem cells, and more.

In the course of researching and writing my own book The Abolition of Aging, I read dozens of different books on broadly similar topics. (For a partial list, scan the online copy of the Endnotes for that book.)

However, I found The Longevity Code to address a number of issues in ways that were particularly compelling and engaging:

  1. Persuasive advice on how to modify diet and lifestyle, now, in order to increase your likelihood to remain healthy long enough to benefit from forthcoming rejuvenation therapies (therapies which Verburgh lists as “Step 4” of a four-stage “longevity staircase”)
  2. A compelling analysis of different “theories of aging”, in Chapter 1 of his book, including the implications of the notably different lifespans of various animals that seem on first sight to have similar biology
  3. A down-to-earth matter-of-fact analysis, in Chapter 4 of his book, on the desirability of living longer lives.

The first of these points is an area where I have often struggled, in the Q&A portions of my own presentations on The Abolition of Aging, to give satisfactory answers to audience questions. I now have better answers to offer!

Allowable weakness

One “allowable weakness” of the book is that the author repeats himself on occasion – especially when it comes to making recommendations on diet and food supplements. I say this is “allowable” because his messages deserve repetition, in a world where there is an abundance of apparent expert dietary advice that is, alas, confusing, contradictory, and often compromised (due to the influence of vested interests – as Verburgh documents).

Table of Contents

The table of contents gives a good idea of what the book contains:

  1. Why do we age?
    • Making room?
    • Dying before growing old
    • Young and healthy, old and sick
    • Sex and aging
  2. What causes aging?
    • Proteins
    • Carbohydrates
    • Fats
    • Our energy generators and their role in life, death, and aging
    • Shoelaces and string
    • Other causes, and conclusion
  3. The longevity staircase
    • Avoid deficiencies
    • Stimulate hormesis
    • Reduce growth stimulation
    • Reverse the aging process
  4. Some thoughts about aging, longevity, and immortality
    • Do we really want to grow that old?
    • A new society?
  5. Recipes
  6. Afterword

About Kris Verburgh

You can read more about the author on the bio page of his website. Here’s a brief extract:

Kris Verburgh (born 1986) graduated magna cum laude as a medical doctor from the University of Antwerp, Belgium.

Dr. Verburgh is a researcher at the Center Leo Apostel for Interdisciplinary Studies (CLEA) at the Free University Brussels (VUB) and a member of the Evolution, Complexity and Cognition group at the Free University of Brussels.

Dr. Verburgh’s fields of research are aging, nutrition, metabolism, preventive medicine and health. In this context, he created a new scientific discipline, called ‘nutrigerontology‘, which studies the impact of nutrition on the aging process and aging-related diseases.

Additionally, he has a profound interest in new technologies that will disrupt medicine, health(care) and our lifespans. He follows the new trends and paradigm shifts in medicine an biotechnology and how they are impacted by the fourth industrial revolution…

Verburgh wrote his first science book when he was 16 years old. At age 25, he had written 3 science books.

Dr. Verburgh gives talks on new developments and paradigm shifts in medicine, healthcare and the science of aging. He gave lectures for the European Parliament, Google, Singularity University, various academic institutes, organizations and international companies.

And I’d be delighted to host him at London Futurists, when schedules allow!

30 November 2017

Technological Resurrection: An idea ripe for discussion

Filed under: AGI, books, death, quantum mechanics, The Abolition of Aging — Tags: , , , — David Wood @ 2:56 pm

Like it or not, humans are becoming as gods. Where will this trend lead?

How about the ability to bring back to life people who died centuries ago, and whose bodies have long since disintegrated?

That’s the concept of “Technological Resurrection” which is covered in the recent book of the same name by Dallas, Texas based researcher Jonathan A. Jones.

The book carries the subtitle “A thought experiment”. It’s a book that can, indeed, lead readers to experiment with new kinds of thoughts. If you are ready to leave your normal comfort zone behind, you may find a flurry of unexpected ideas emerging in your mind as you dip into its pages. You’re likely also to encounter considerable emotional turmoil en route.

The context

Here’s the context. Technology is putting within human reach more and more of the capabilities that were thought, in former times, to be the preserve of divine beings:

  • We’re not omniscient, but Google has taken us a long way in that direction
  • We’re not yet able to create life at will, but our skills with genomic engineering are proceeding apace
  • Evolution need no longer proceed blindly, via Darwinian Russian roulette, but can benefit from conscious intelligent design (by humans, for humans)
  • Our ability to remake nature is being extended by our ability to remake human nature.
  • We can enable the blind to see, the deaf to hear, and the lame to walk
  • Thanks to medical breakthroughs, we can even bring the dead back to life – that is, the cessation of heart and breath need no longer herald an early grave.

But that’s just the start. It’s plausible that, sooner or later, humanity will create artificial superintelligence with powers that are orders of magnitude greater than anything we currently possess. These enhanced powers would bring humanity even closer to the domain of the gods of bygone legends. These powers might even enable technological resurrection.

Some details

In more detail: Profound new engineering capabilities might become available that can bridge remote sections of space and time – perhaps utilising the entanglement features of quantum physics, perhaps creating and exploiting relativistic “wormholes”, or perhaps involving unimagined novel scientific principles. These bridges might allow selected “copying” of consciousness from just before the moment of death, into refined bodies constructed in the far future ready to receive such consciousness. As Jonathan Jones explores, this copying might take place in ways that circumvent the time travel paradoxes that often feature in science fiction.

That’s a lot of “mights” and “maybes”. However, when contemplating the range of ideas for what might happen to consciousness after physical death, it would be wise to include this option. Beyond our deathbed, we might awaken to find ourselves in a state akin to paradise – surrounded by resurrected family and friends. Born 1945, died 2020, resurrected 2085? Born 1895, died 1917, resurrected 2087?

The book contains a number of speculative short stories to whet readers’ appetites to continue this exploration. These stories add colour to what is already a colourful, imaginative book. The artistic license is grounded in a number of solid references to science, philosophy, psychology, and history. For example, there’s a particularly good section on Russian “cosmist” thinkers. There’s a review of how films and novels have dealt with similar ideas over the decades. And the book is brought up to date with a discussion of contemporary transhumanists, including Ray Kurzweil, Ben Goertzel, Jose Cordeiro, and Giulio Prisco.

Futurists like to ask three questions about forthcoming scenarios. Are they credible (as opposed to being mere flights of fantasy). Are they actionable, in that individual human actions could alter their probability of occurring. And are they desirable.

All three questions get an airing in the pages of the book Jonathan Jones has written. To keep matters short, for now I’ll focus on the third question.

The third question

The idea of technological resurrection could provide much-needed solace, for people whose lives otherwise seem wretched. Perhaps death will cease to be viewed as a one-way ticket to eternal oblivion. What’s more, the world might benefit mightily from a new common quest to advance human capability, safely, beyond the existential perils of modern social angst, towards being able to make technological resurrection a reality. That’s a shared purpose which would help humanity transcend our present-day pettiness. It’s a route to make humanity truly great.

However, from other points of view, the idea of technological resurrection could be viewed as an unhelpful distraction. Similar to how religion was criticised by Karl Marx as being “the opium of the people” – an illusory “pie in the sky when you die” – the vague prospect of technological resurrection could dissuade people from taking important steps to secure or improve long-term health prospects. It might prevent them from:

  • Investigating and arranging cryonics support standby services
  • Channelling funds and resources to those researchers who may be on the point of abolishing aging
  • Encouraging the adoption of health-promoting lifestyles, economic policies, and beneficial diets and supplements
  • Accelerating the roll-out of technoprogressive measures that will raise people around the world out of relative poverty and into relative prosperity.

Finally, the idea of technological resurrection may also fill some minds with dread and foreboding – if they realise that devious, horrible actions from their past, which they believed were secret, might become more widely known by a future superintelligence. If that superintelligence has the inclination to inflict a punitive (hellish) resurrection, well, things gain a different complexion.

There’s a great deal more that deserves to be said about technological resurrection. I’m already thinking of organising some public meetings on this topic. In the meantime, I urge readers to explore the book Jonathan Jones has written. That book serves up its big ideas in ways that are playful, entertaining, and provocative. But the ideas conveyed by the light-hearted text may live in your mind long after you have closed the book.

PS I’ve addressed some of these questions from a different perspective in Chapter 12, “Radical alternatives”, of my own 2016 book “The Abolition of Aging”.

14 March 2017

Public events – chances to watch me speak

Filed under: Events, The Abolition of Aging, Transpolitica — Tags: , , , , , , , , , — David Wood @ 10:14 am

Here are a few places I’ll be speaking at public events over the next few weeks.

If you happen to be in one of these neighbourhoods, and the timing works for you, it would be great to see you there.

(1) Funzing experience, London EC2A 4JH, Tues 25th April

I’ve only recently found out about Funzing. They connect event hosts and event guests, to allow more people to discover and share experiences that are engaging, interesting, and (yes) fun. Categories of experience on offer include tours and walks, comedy and music shows, craft and DIY workshops, and inspiring talks and lectures.

As an experiment, I’m speaking at one of these events on Tuesday 25th April. My topic will be “Can we abolish aging?”

By 2040, could we have abolished what we now know as biological aging?

It’s a big “if”, but if we decide as a species to make this project a priority, there’s around a 50% chance that practical rejuvenation therapies resulting in the comprehensive reversal of aging will be widely available as early as 2040.

People everywhere, on the application of these treatments, will, if they wish, stop becoming biologically older. Instead, again if they wish, they’ll start to become biologically younger, in both body and mind, as rejuvenation therapies take hold. In short, everyone will have the option to become ageless.

This suggestion tends to provoke two powerful objections. First, people say that it’s not possible that such treatments are going to exist in any meaningful timescale any time soon. In other words, they insist that human rejuvenation can’t be done. It’s wishful thinking to suppose otherwise, they say. It’s bad science. It’s naively over-optimistic. It’s ignorant of the long history of failures in this field. The technical challenges remain overwhelmingly difficult.

Secondly, people say that any such treatments would be socially destructive and morally indefensible. In other words, they insist that human rejuvenation shouldn’t be done. It’s essentially a selfish idea, they say – an idea with all kinds of undesirable consequences for societal harmony or planetary well-being. It’s an arrogant idea, from immature minds. It’s an idea that deserves to be strangled.

Can’t be done; shouldn’t be done – this talk will argue that both these objections are profoundly wrong. The speaker will argue instead that rejuvenation is a noble, highly desirable, eminently practical destiny for our species – a “Humanity+” destiny that could be achieved within just one human generation from now. The abolition of aging is set to take its place on the upward arc of human social progress, echoing developments such as the abolition of slavery, the abolition of racism, and the abolition of poverty…

Funzing clock

For more details, visit the Funzing event page.

Note: you can use the code ‘david10‘ for 10% discount from the normal Funzing entry fee.

For details of other events where I’ll be speaking on themes related to radical extension of healthy life expectancy, keep your eyes on this list.

(2) The future of politics, Manchester, Fri 24th March

Manchester Futurists were founded in January this year, announcing themselves to the world as follows:

We are fascinated by how technological advancement will shape the future, and the social, ethical and economic challenges humanity will face. Come talk about it with us!

We plan to hold regular meetups that introduce concepts relating to futurism, followed by an informal discussion on the subject. Probably followed by the pub 🙂 …

We aim to take an evidence-based approach and avoid pseudoscience. We believe social justice is important to a utopian future, and where appropriate will discuss intersections with feminism, racism, etc…

Join us to exercise your brain, discuss the future and meet people with a passion for technology!

I’ll be their guest speaker on Friday 24th March. Click here for more details and to RSVP.

It will be a chance for me to share some ideas from my forthcoming new book “Fixing Politics: A Technoprogressive Roadmap to a Radically Better Future”.

Cover v2

(This placeholder book cover design is intended to suggest that our political infrastructure is in a perilous state of ruin.)

(3) The case for transhumanism, Brighton, Tues 11th April

On the evening of Tuesday 11th April I’ll be the guest speaker at Brighton Skeptics in the Cafe, presenting the case for transhumanism.

Three logos

Here’s a collection of good definitions of transhumanism, taken from H+Pedia:

  • “Transhumanism is a class of philosophies of life that seek the continuation and acceleration of the evolution of intelligent life beyond its currently human form and human limitations by means of science and technology, guided by life-promoting principles and values” – Max More, 1990
  • “Transhumanism is a way of thinking about the future that is based on the premise that the human species in its current form does not represent the end of our development but rather a comparatively early phase” – Transhumanist FAQ
  • “Transhumanism is the philosophy that we can and should develop to higher levels, both physically, mentally and socially using rational methods” – Anders Sandberg, 1997
  • “Transhumanists view human nature as a work-in-progress, a half-baked beginning that we can learn to remould in desirable ways. Current humanity need not be the endpoint of evolution. Transhumanists hope that by responsible use of science, technology, and other rational means we shall eventually manage to become posthuman beings with vastly greater capacities than present human beings have” – Nick Bostrom, 2003
  • “Transhumanism promotes an interdisciplinary approach to understanding and evaluating the opportunities for enhancing the human condition and the human organism opened up by the advancement of technology; attention is given to both present technologies, like genetic engineering and information technology, and anticipated future ones, such as molecular nanotechnology and artificial intelligence” – Nick Bostrom, 2003
  • “Transhumanism is the science-based movement that seeks to transcend human biological limitations via technology” – Philippe van Nedervelde, 2015
  • “Transhumanism anticipates tomorrow’s humanity: Envisaging the positive qualities and characteristics of future intelligent life; Taking steps towards achieving these qualities and characteristics; Identifying and managing risks of negative characteristics of future intelligent life” – Transpolitica website, 2015

At the event, I’ll be setting out my personal vision of “Transhumanism for all”:

  • “Transhumanist benefits for all” – The tremendous benefits of new technology should become available to anyone who wishes to take advantage of them (rather than being restricted to the well off or the well connected)
  • “Transhumanist thinking for all” – The core transhumanist memes should become understood, accepted, and endorsed by a wider and wider set of people, from all walks of life, en route to becoming the default worldview in more and more areas of society.

(4) Artificial Intelligence transforming healthcare, Lyon, Wed 5th April

Biovision Full

Biovision is holding a World Life Sciences Forum from 4th to 6th April in Lyon, France:

This year’s topic in ‘From Global health to One health’. One health is “the collaborative effort of multiple disciplines – working locally, nationally, and globally – to attain optimal health for people, animals and the environment”.

The event will have six main themes:

  • Global medical education & training
  • Digital health and innovation for sustainable healthcare
  • Emerging viral diseases
  • Animal health
  • Innovative technologies
  • Science of metagenomics.

I’ll be part of a multi-talented panel on the Wednesday: “Artificial Intelligence: A generous revolution serving health”.

For more details, click here.

(5) Postscript – forthcoming London Futurists events

Don’t forget that London Futurists regularly hold discussion events on Saturday afternoons in Birkbeck College, central London. I chair these events to help ensure a rich flow of questions and answers.

Forthcoming London Futurists events are listed here (with links to more information):

The event this Saturday features Azeem Azhar, the curator and publisher of the phenomenally interesting weekly newsletter “The Exponential View”. Azeem’s topic is “The age of technology has arrived. Now what?”

LonFut AA 18 March 2017.png

 

4 July 2016

Learning by doing: Experimenting with audio

Filed under: The Abolition of Aging — Tags: , , , — David Wood @ 7:47 pm

I keep receiving requests to create an audio version of my book The Abolition of Aging.

That’s a request I fully understand. My own preferred format for books is Audible. I listen to an average of two books a month, from my Audible subscription, usually while I’m walking or driving. When I can’t find an Audible version of a book, I’m disappointed.

So here’s my update.

After researching some options, I’ve created a recording of myself reading the introductory material from The Abolition of Aging. I’ve made that recording available for everyone to listen to, free of charge, here: https://theabolitionofaging.files.wordpress.com/2016/07/01-intro.mp3. The length is 21 minutes.

Before I take the time to record the main content of the book, I’d appreciate some feedback. Which of the following would you endorse?

  1. The quality of the initial recording is good enough. Hurry up and record the other chapters in the same way.
  2. The quality is nearly good enough, but more practice is needed. Consider redoing at least part of this experiment.
  3. The idea is sound, but some of the tools (*) need to be changed.
  4. Don’t mess around. Hire a professional voice artist to read the book.

Books with Zoom recorder 2

(*) I’ve recorded in an upstairs room at home (my house is relatively quiet), with my laptop switched off so there’s no background hum from the cooling fan. I recorded to a Zoom H2n Handy Recorder, before switching my laptop on again and using Audacity software to edit the files. I found I put more spirit into the recording when I was standing up, rather than sitting down.

23 June 2016

Acceptance and change

Filed under: aging, The Abolition of Aging — Tags: , , , , , , — David Wood @ 9:46 am

Is it narcissist to seek a cure for aging? Is it egocentric or immature?

That’s an accusation that often comes my way.

The short answer is that it’s no more narcissist to seek a cure for aging than it is to seek a cure for cancer, or for dementia. (Moreover, as I argue in Chapter 2 of my book The Abolition of Aging, the most effective route to cure cancer may well be to cure aging first.)

Nor was it narcissist of previous medical pioneers to seek cures for TB, or for malaria.

Nor was it narcissist for slaves to dare to want to be free of their bondage. Nor was it narcissist for women to dare to want the right to vote. Thank goodness.

Suffragettes 1024x576

There’s a section in Chapter 1 of The Abolition of Aging where I review a variant of this argument. Here’s a copy of that section.

Acceptance and change

At first glance, rejuveneers seem to stand opposed to a profound piece of humanitarian wisdom – wisdom expressed by, among others, Gautama Buddha, 2nd century Stoic advocate Marcus Aurelius, and 20th century American Protestant theologian Reinhold Niebuhr.

That wisdom urges serenity and acceptance in the face of life’s deep challenges. There’s no merit in becoming unnecessarily agitated about an issue – such as the onset of aging – if there’s nothing that can be done about that issue. Why discuss a painful problem if you can’t change the outcome? What’s the point of complaining if there’s no solution available?

It’s as stated in the opening lines of Niebuhr’s famous “serenity prayer” (a prayer that everyone can appreciate, without any need to believe in a supernatural deity):

God grant me
The serenity to accept the things I cannot change…

A similar thought lies at the heart of Buddhism. The “Four Noble Truths” state that suffering arises from attachment to desires, and that suffering ceases only when attachment to desire ceases. To transcend the omnipresence of suffering, we have to learn to accept life as it is, and to set aside desire – such as the desire for better material possessions, pleasure, security, or long life.

The Stoic philosophy of life, developed in ancient Greece and Rome, likewise emphasises an attitude of acceptance. As Epictetus (55-135 AD) stated,

Freedom is secured not by the fulfilling of men’s desires, but by the removal of desire.

Stoic advocate Marcus Aurelius (121-180 AD), who was emperor of Rome for the last 19 years of his life, posed the following questions in his “Meditations”:

Why do you hunger for length of days? The point of life is to follow reason and the divine spirit and to accept whatever nature sends you. To live in this way is not to fear death, but to hold it in contempt. Death is only a thing of terror for those unable to live in the present. Pass on your way, then, with a smiling face, under the smile of him who bids you go.

Admiration of “Stoic calm” persists to the present day. Former American president Bill Clinton has been quoted as saying that “Meditations of Marcus Aurelius” was his favourite book. Stoicism is highlighted by self-education advocate Paul Jun as providing “9 Principles to Help You Keep Calm in Chaos”:

Not only does philosophy teach us how to live well and become better humans, but it can also aid in overcoming life’s trials and tribulations. Some schools of thought are for more abstract thinking and debate, whereas others are tools that are immediately practical to our current endeavours.

The principles within Stoicism are, perhaps, the most relevant and practical sets of rules for entrepreneurs, writers, and artists of all kinds. The Stoics focus on two things:

  1. How can we lead a fulfilling, happy life?
  2. How can we become better human beings?

The goal of Stoicism is to attain inner peace by overcoming adversity, practicing self-control, being conscious of our impulses, realizing our ephemeral nature and the short time allotted—these were all meditative practices that helped them live with their nature and not against it.

It is in contrast to these philosophies of mature acceptance – philosophies that emphasise uncomplaining acknowledgement of our finitude and our limits – that rejuveneers can be portrayed as arrogant, grasping, and juvenile. Rejuveneers dare to complain about the perceived insult of deteriorative aging. Rejuveneers have the audacity to imagine that an outcome unavailable to the greats of the past – including giants such as Marcus Aurelius, Reinhold Niebuhr, and Gautama Buddha – namely, the option of indefinite youthfulness – might shortly be available to present-day folk. Rejuveneers, according to this line of thought, lack the self-awareness to realise how unreasonable their ambition is. Indeed, the hubris of the rejuveneers can seem absurd.

Three sages

But the quotes given above tell only a part of the story. For example, there’s more to Buddhism than acceptance. Buddhist mindfulness coach Sunada Takagi comments as follows:

Acceptance is the first step toward change

I recently had a couple people raise doubts to me about the Buddhist idea of “accepting what is.” Isn’t it too passive? What if we’re in a situation that’s really unacceptable?

I’ve come across a few things recently that speak to this. Each makes a slightly different point, but they all basically say the same thing. “Accepting what is” does not mean passive acquiescence. Far from it, it’s the first step in making real and lasting change…

So “accepting what is” is not about passivity at all. It’s about clear seeing… Paradoxically, it’s when we take responsibility for our own failings and difficulties, or those of the world around us, that the real process of change can begin to take place. I see it as an essential starting point for anything we take on in life.

Paul Jun, the writer I quoted above on the Stoic philosophy, also adopts a strong action-orientation. For him, being stoical is far from being passive. It can, as he says, be the prelude to urgency:

Remind yourself that time is our most precious resource

What I particularly love and find challenging about Stoicism is that death is at the forefront of their thoughts. They realized the ephemeral nature of humans and how this is repeated in many facets of life.

It provides a sense of urgency, to realize that you’ve lived a certain number of hours and the hours ahead of you are not guaranteed as the ones you have lived. When I think of this I realize that everyday truly is an opportunity to improve, not in a cliché kind of way, but to learn to honestly appreciate what we are capable of achieving and how we are very responsible for the quality of our lives.

This makes our self-respect, work ethic, generosity, self-awareness, attention, and growth ever more important. The last thing any of us wants to do is die with regret, hence why following principles of Stoicism puts your life into perspective. It humbles you and should also deeply motivate you.

That brings us back to the serenity prayer of Reinhold Niebuhr. Above, I quoted the first clause of that prayer – the so-called “acceptance clause”. But there are two more clauses: an action clause and a wisdom clause. Here’s the entirety:

God grant me
The serenity to accept the things I cannot change
The courage to change the things that I can
And the wisdom to know the difference.

Just as people can, rightly, be criticised for foolhardily attempting to change something that cannot be altered, so also can they, again rightly, be criticised for passively accepting some massive flaw or shortcoming which, it turns out, lay within their capacity to fix.

The most important clause in this prayer, arguably, is the “wisdom clause”: if we can find out, objectively, whether something lies within our collective ability, it makes all the difference as to whether the right thing to do is to seek accommodation or to seek transformation.

For rejuveneering, I have no doubt that the right thing to do is to seek transformation. Doing otherwise would be akin – to borrow another motif from Christian heritage – to walking past on the other side of the road, keeping well away from an unfortunate traveller who has been mugged, stripped of his clothing, and left half dead. When regarding the unfortunate state of everyone around the world that is already “half dead” due to the approach of diseases of old age, who amongst us will prove to be a “good Samaritan” that sees the plight and provides tangible support? And who, in contrast, will be like the priest and the Levite of the biblical parable, rushing past with eyes averted, preoccupied with whatever else fits the accepting-aging paradigm?

Footnote

I’ll be addressing some of the themes of The Abolition of Aging at a London Futurists event this Saturday. Click here for more details.

DW Scenarios for life extension Slide 18

10 June 2016

Lessons from Underground Airlines

Filed under: aging, books, deception, The Abolition of Aging — Tags: , , , , , , , — David Wood @ 11:30 pm

In the grand sweep of history, how much difference can one person make?

For example, consider the influence of Abraham Lincoln, 16th President of the United States. What alternative history might have arisen if that great statesman had been felled by an assassin’s bullet, not (as in actual history) in 1865, after the conclusion of the American Civil War, but much earlier in his presidency?

That alternative scenario provides the backdrop to the speculative novel “Underground Airlines” by Ben H. Winter. It’s a novel that speculates, masterfully, about the trajectory of an alternative history.

Underground Airlines

Imagine if early martyrdom of Lincoln, before any civil war could start, had precipitated a colossal long-standing compromise in the United States, with northern anti-slavery states warily coexisting with southern pro-slavery states, not just for a few more years, but for long decades – indeed, right up until the present day. Imagine if the “underground railroad” rescue mechanism of safe houses and secret routes to transport fugitive escaped slaves, that existed in actual history from the 17th to the 19th century, persisted in modified, modernised form right up until the twenty first century, now known as “underground airlines” (the words which form the title of Winter’s book). Imagine if the latest features of modern society – such as GPS tracking and ubiquitous mobile computers – coexisted with industrial scale slavery in the “Hard Four” recalcitrant states of the deep south. And, worst of all, imagine an extension, right up till today, of the massive double think (self-deception) in which good people persuade themselves that the whole system is acceptable. Imagine the double think with which these bystanders view fugitive slaves on the run, as fair game to be hunted by trackers from the south acting on behalf of massive slave-holding conglomerates.

Winter’s book features double think writ large. Characters that, to outward appearances, seek to help runaway slaves, are secretly assisting the trackers, and allow themselves to feel comfortable with that double think. They accept the brute facts of slavery, and make peace (of a sort) with their personal accommodation to that worldview.

Personalities from actual history intrude, under the skilful choreography of the writer, into the alternative Underground Airlines history. Shunned by much of the rest of the industrialised world, the alternative America occupies a relative backwater on the global stage. The FDR and LBJ mentioned in quiet moments in the narrative wielded an impact far more local, in Underground Airlines history, than in actual history. A reference to a recent “gulf war” turns out to have nothing to do with the Middle East.

More than clever plotting

Winter’s book deserves praise for its clever plotting. Revelations of character motivations come as surprises, but not as jolts: the reader is gradually made aware of a bigger picture with its own, horrible logic. It adds up to gripping reading.

But more than that: Underground Airlines deserves praise for its astuteness in recognising that there was nothing inevitable about the abolition of slavery. The circumstances that we nowadays find overwhelmingly objectionable – the “Inhuman Bondage” described at length by real-world historian David Brion Davis in his epic account of the rise and fall of new world slavery – could be seen by otherwise admirable men and women as necessary, inevitable parts of a way of life that has many redeeming positive aspects. These apologists were wrapped in a set of perceptions – their “accepting slavery” paradigm – which prevented them from acknowledging the full awfulness of bound servitude. Despite their intelligence, their thinking was constrained. Despite the kindness that lay in their hearts, there were marked limits to their compassion.

Inhuman Bondage

I came across the work of David Brion Davis in the course of researching my own recently published book, The Abolition of Aging. Here’s an extract from near the end of my book:

The analysis by Davis makes it clear that:

  • The abolition of slavery was by no means inevitable or predetermined
  • There were strong arguments against the abolition of slavery – arguments raised by clever, devout people in both the United States and the United Kingdom – arguments concerning economic well-being, among many other factors
  • The arguments of the abolitionists were rooted in a conception of a better way of being a human – a way that avoided the harsh bondage and subjugation of the slave trade, and which would in due course enable many millions of people to fulfil a much greater potential
  • The cause of the abolition of slavery was significantly advanced by public activism – including pamphlets, lectures, petitions, and municipal meetings.

With its roots in the eighteenth century, and growing in momentum as the nineteenth century proceeded, the abolition of slavery eventually became an idea whose time had come – thanks to brave, smart, persistent activism by men and women with profound conviction.

With a different set of roots in the late twentieth century, and growing in momentum as the twenty-first century proceeds, the abolition of aging can, likewise, become an idea whose time has come. It’s an idea about an overwhelmingly better future for humanity – a future that will allow billions of people to fulfil a much greater potential. But as well as excellent engineering – the creation of reliable, accessible rejuvenation therapies – this project will also require brave, smart, persistent activism, to change the public landscape from one hostile (or apathetic) to rejuveneering into one that deeply supports it.

My claim in The Abolition of Aging is that most of us accept a terrible double think. We avidly support research against diseases such as cancer, dementia, and heart failure. We are aware of the destructive nature of all these diseases. But we shy away from research into the main underlying escalator of these diseases – the factor that makes these diseases more likely and (when they occur) more serious. This factor is biological aging – namely, the gradual deterioration of our molecular, cellular, and organic systems. We’re too ready to accept biological aging as a given.

We say it would be good if people could avoid being afflicted by cancer, dementia, or heart failure. We advocate people taking steps to decrease the chances of these diseases – for example, not to spend too much time under the direct sun, unprotected. But we tell ourselves that it’s somehow natural (and therefore somehow admirable) that biological aging accelerates in our bodies. So we acquiesce. We accept a deadly compromise.

The Abolition of Aging seeks to overturn that double think. It argues that rejuvenation is a noble, highly desirable, eminently practical destiny for our species – a “Humanity+” destiny that could, with sufficient focus and organisation, be achieved within just one human generation from now. Rejuvenation – the periodic reversal of the accumulation of significant damage at our molecular, cellular, and organic levels – can lead to a rapid decline in deaths from diseases of old age, such as cancer, dementia, heart failure, and lots more. Despite the implications of this change for our economic and social systems, this is an overwhelming good, which we should welcome wholeheartedly.

I’m happy to report that The Abolition of Aging has already featured as the #1 bestseller (in the UK) of the Gerontology section of Amazon.

Gerontology bestsellers UK

Next steps

Let’s return to the question from the start of this blogpost: In the grand sweep of history, how much difference can one person make?

We can’t all be Abraham Lincoln. But as I review in the final sections of my book, there’s a lot that each one of us can do, to tilt upwards the probability that successful rejuvenation therapies will be widely available by 2040. This includes steps to:

  1. Strengthen communities that are working on at least parts of the rejuveneering project
  2. Improve our personal understanding of aspects of rejuveneering – the science, roadmaps, history, philosophy, theories, personalities, platforms, open questions, and so on – and help to document aspects of that better understanding, by creating or editing knowledgebases or wikis
  3. Become involved with marketing of one sort or another
  4. Undertake original research into any of the unknowns of rejuveneering; this could be part of formal educational courses, or it could be a commercial R&D undertaking; it could also be part of a decentralised activity, in the style of “citizen science”
  5. Provide funding to projects that we judge to be particularly worthwhile.

Our contributions are likely to be more significant when they connect into positive efforts that others are already making. For example, I’m impressed by the activities of the Major Mouse Testing Program (MMTP), which you can read about here. I’ve just made a contribution to their crowdfunding campaign, and I encourage you to consider doing the same.

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